NCT07716319

Brief Summary

The purpose of this study is to compare the effects of an intensity-, volume-, and time under tension-matched eccentric hamstring exercise intervention with the Romanian deadlift (RDL) and the Nordic hamstring exercise (NHE) to a sprint-specific training program on hamstring muscle architecture, volume, sprint performance, strength, and power. Participants will be assigned to complete one of the 3 hamstring interventions for 10 weeks.

Trial Health

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Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
90

participants targeted

Target at P50-P75 for not_applicable

Timeline
12mo left

Started Sep 2026

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

July 7, 2026

Completed
14 days until next milestone

First Posted

Study publicly available on registry

July 21, 2026

Completed
1 month until next milestone

Study Start

First participant enrolled

September 1, 2026

Expected
1 year until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2027

Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2027

Last Updated

July 21, 2026

Status Verified

July 1, 2026

Enrollment Period

1 year

First QC Date

July 7, 2026

Last Update Submit

July 15, 2026

Conditions

Keywords

strengthagilitysprinthypertrophycountermovement jumpfascicle lengthhamstringrange of motion

Outcome Measures

Primary Outcomes (4)

  • Change in fascicle length (FL)

    Baseline to Mid-intervention (6 weeks), Post-intervention (10 weeks), and Post 2 week de-training (12 weeks)

  • Change in muscle cross-sectional area (CSA)

    Baseline to Mid-intervention (6 weeks), Post-intervention (10 weeks), and Post 2 week de-training (12 weeks)

  • Change in muscle volume

    Baseline to Mid-intervention (6 weeks), Post-intervention (10 weeks), and Post 2 week de-training (12 weeks)

  • Change in pennation angle (PA)

    Baseline to Mid-intervention (6 weeks), Post-intervention (10 weeks), and Post 2 week de-training (12 weeks)

Secondary Outcomes (8)

  • Change in eccentric strength

    Baseline to Mid-intervention (6 weeks), Post-intervention (10 weeks), and Post 2 week de-training (12 weeks)

  • Change in inertial measurement units (IMU)-based sprinting biomechanics

    Baseline to Mid-intervention (6 weeks), Post-intervention (10 weeks), and Post 2 week de-training (12 weeks)

  • Change in countermovement jump (CMJ) performance

    Baseline to Mid-intervention (6 weeks), Post-intervention (10 weeks), and Post 2 week de-training (12 weeks)

  • Change in standing broad jump (SBJ) performance

    Baseline to Mid-intervention (6 weeks), Post-intervention (10 weeks), and Post 2 week de-training (12 weeks)

  • Change in change of direction (CoD) performance

    Baseline to Mid-intervention (6 weeks), Post-intervention (10 weeks), and Post 2 week de-training (12 weeks)

  • +3 more secondary outcomes

Study Arms (3)

Romanian dead lift (RDL) group

EXPERIMENTAL

The training intervention groups will undergo the same program with the only difference being the interventional hamstring exercise. The program will consist of a 2-week familiarization period followed by 8 weeks of progressive training. The RDL arm will perform RDL.

Other: RDL

Nordic hamstring exercise (NHE) group

EXPERIMENTAL

The training intervention groups will undergo the same program with the only difference being the interventional hamstring exercise. The program will consist of a 2-week familiarization period followed by 8 weeks of progressive training. The NHE arm will performed NHE

Other: NHE

Sprint group

EXPERIMENTAL

The training intervention groups will undergo the same program with the only difference being the interventional hamstring exercise. The program will consist of a 2-week familiarization period followed by 8 weeks of progressive training. The sprint training program will be performed twice per week with the first day of training focused on shorter distances to focus on acceleration and the second training day focused on maximal velocity. The relative efforts and distances for each training day will mimic a similar prescription to that of the resistance training program.

Other: Sprint testing

Interventions

RDLOTHER

The RDL will be performed with a 6 second eccentric component with the athlete returning to the start position with a maximal concentric hip extension.

Romanian dead lift (RDL) group
NHEOTHER

The NHE will be performed with a 6 second eccentric component.

Nordic hamstring exercise (NHE) group

The sprint training program will be performed twice per week with the first day of training focused on shorter distances to focus on acceleration and the second training day focused on maximal velocity. The relative efforts and distances for each training day will mimic a similar prescription to that of the resistance training program.

Sprint group

Eligibility Criteria

Age18 Years - 25 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Age 18-25 years
  • Actively participating in a club team
  • \>6 months experience with resistance training
  • Minimum of 1 year experience at the high school level in organized team sport
  • No history of hamstring injury within the last 6 months
  • No history of major lower extremity surgery (including back)
  • No acute musculoskeletal injury to the lower extremity
  • Not currently pregnant

You may not qualify if:

  • Unable to refrain from resistance training outside the study
  • Unable to make at least 80% of the training sessions
  • Hamstring injury in the last 6 months
  • History of major lower extremity surgery (including back)
  • Acute musculoskeletal injury to the lower extremity
  • Currently pregnant

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Wisconsin - Madison

Madison, Wisconsin, 53705, United States

Location

MeSH Terms

Conditions

Hypertrophy

Condition Hierarchy (Ancestors)

Pathological Conditions, AnatomicalPathological Conditions, Signs and Symptoms

Central Study Contacts

Scott K Crawford, PhD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
OTHER
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 7, 2026

First Posted

July 21, 2026

Study Start (Estimated)

September 1, 2026

Primary Completion (Estimated)

September 1, 2027

Study Completion (Estimated)

September 1, 2027

Last Updated

July 21, 2026

Record last verified: 2026-07

Data Sharing

IPD Sharing
Will not share

Locations