Clinical Efficacy of Antivet Versus Phosphoric Acid and Hydrochloric Acid in Microabrasion

NCT07709286 | Recruiting Phase 1 FDA Drug

• 1 other identifier: 49
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This clinical trial will be conducted to assess the clinical efficacy of using Antivet cleaning enamel solution or hydrochloric acid and phosphoric acid in microabrasion technique for mild to moderate intrinsic stained teeth.

Conditions

Teeth Staining

Keywords

tooth discoloration; microabrasion; antivet

Outcome Measures

Primary Outcomes (1)

• Clinical performance

  visual analog scale using scoring system

  three months

Study Arms (3)

phosphoric acid 37% and aluminium oxid 50 microns

ACTIVE COMPARATOR

Microabrasion technique could be considered as the first treatment option when trying to improve the esthetics of teeth that present with mild or moderate intrinsic stains as it is a simple, safe, atraumatic, minimally invasive single visit procedure with high success rate

Drug: phosphoric acid 37% and aluminium oxid 50 microns

Opalustre™

ACTIVE COMPARATOR

a mixture of 37% phosphoric acid gel in extra fine grain pumice or 18% hydrochloric acid in pumice or 6.6% and 10% hydrochloric acid with silica carbide particles, with rubber cup in slow rotating motion to the areas of discoloration or white opacities. Another advantage of microabrasion technique is that it leaves the treated enamel surface as highly polished which minimizes the cariogenic bacteria colonization and render it more resistant to demineralization

Drug: Opalustre

Antivet

EXPERIMENTAL

The Antivet Kit solution is specially formulated to eliminate stains on the enamel surface caused by dental fluorosis or any other external factor.The tooth's surface is exposed to an acid solution by ionization by the fluoride absorbed in the apatite crystals (stains). This reaction allows for the fluoride ions to separate from the fluoride ions in the apatite crystals, forming soluble salts that are easily removed from the tooth enamel surface. Once the stains are removed, a calcium hydroxide solution is applied to neutralize the residual acidic solution left on the tooth surface. Lastly, the tooth is rinsed with water.Acid Base (Antivet): It is hydrofluoric acid at a 21% concentration stabilized by an organic tricarboxylic acid, with a controlled pH of \<3, necessary to react with the fluoride ions to form soluble salts. The organic and inorganic ions are extracted from within the fluorapatite crystals through this ionization process which essentially allows the enamel surface to be

Drug: (Antivet, MDC DENTAL, Zapopan Jalisco México)

Interventions

(Antivet, MDC DENTAL, Zapopan Jalisco México) DRUG

specially formulated to eliminate stains on the enamel surface caused by dental fluorosis or any other external factor.The tooth's surface is exposed to an acid solution by ionization by the fluoride absorbed in the apatite crystals (stains). This reaction allows for the fluoride ions to separate from the fluoride ions in the apatite crystals, forming soluble salts that are easily removed from the tooth enamel surface. Once the stains are removed, a calcium hydroxide solution is applied to neutralize the residual acidic solution left on the tooth surface. Lastly, the tooth is rinsed with water.Acid Base (Antivet): It is hydrofluoric acid at a 21% concentration stabilized by an organic tricarboxylic acid, with a controlled pH of \<3, necessary to react with the fluoride ions to form soluble salts. The organic and inorganic ions are extracted from within the fluorapatite crystals through this ionization process which essentially allows the enamel surface to be cleansed without damaging it

Antivet

Opalustre DRUG

technique involves employing a mixture 6.6% hydrochloric acid with silica carbide particles, with rubber cup in slow rotating motion to the areas of discoloration or white opacities for 60 seconds. The teeth will be rinsed with water between slurry applications. Depending on the stain reduction, microabrasion will be repeated up to six times during the same appointment to achieve the desired result. .

Opalustre™

phosphoric acid 37% and aluminium oxid 50 microns DRUG

● Equal quantities from phosphoric acid 37% and aluminium oxid 50 microns will be mixed, thick mix will be applied on the affected tooth/teeth and will be rubbed with a rubber cup in a low-speed contra-angle handpiece for 60 seconds of each application. Every patient will be received the entire microabrasion treatment in a single appointment with a maximum of 6 applications.

phosphoric acid 37% and aluminium oxid 50 microns

Eligibility Criteria

• Age: 16 Years - 50 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Patients with moderate to mild stained teeth.
• years.
• Males or Females.
• Co-operative patients approving to participate in the study.

You may not qualify if:

• High caries index with poor oral hygiene.
• Severe medical complications.
• Pregnancy.
• Xerostomia.
• Lack of compliance.
• Smokers
• Eligibility Criteria of teeth:
• Anterior teeth.
• Mild to moderate intrinsic or extrinsic stains.
• Vital and non-sensitive anterior teeth.
• pitted enamel.
• carious teeth.
• Deep lesions.
• Severe periodontal problems.
• Previous treatment for the stained teeth

Sponsors & Collaborators

• Misr University for Science and Technology: lead

Study Sites (1)

Egyptian Russian University

Badr, Cairo Governorate, 11829, Egypt

RECRUITING

Related Publications (1)

• Blanchet I, Camoin A, Tardieu C, Jacquot B. Microabrasion in the management of enamel discolorations in paediatric dentistry: a systematic review. J Clin Pediatr Dent. 2023 Jan;47(1):17-26. doi: 10.22514/jocpd.2022.015. Epub 2023 Jan 3.

  PMID: 36627216 BACKGROUND

MeSH Terms

Conditions

Tooth Discoloration

Interventions

opalustre; phosphoric acid

Condition Hierarchy (Ancestors)

Tooth Diseases; Stomatognathic Diseases

Study Officials

• Esraa Esmeail Hussien EEH Elhaddad, PHD

  Misr University for Science and Technology

  STUDY DIRECTOR

Central Study Contacts

Esraa Esmeail Hussien EEH Lecturer, phd holder

CONTACT

0201111103836; dr.esraaism@gmail.com

Dina Fayez Diab DFD Lecturer, phd holder

CONTACT

+201146633390; Dina.Fayez.Diab@gmail.com

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer at Misr university for science and technology

Model Details: The Antivet Kit solution is specially formulated to eliminate stains on the enamel surface caused by dental fluorosis or any other external factor.The tooth's surface is exposed to an acid solution by ionization by the fluoride absorbed in the apatite crystals (stains). This reaction allows for the fluoride ions to separate from the fluoride ions in the apatite crystals, forming soluble salts that are easily removed from the tooth enamel surface. Once the stains are removed, a calcium hydroxide solution is applied to neutralize the residual acidic solution left on the tooth surface. Lastly, the tooth is rinsed with water.Acid Base (Antivet): It is hydrofluoric acid at a 21% concentration stabilized by an organic tricarboxylic acid, with a controlled pH of \<3, necessary to react with the fluoride ions to form soluble salts. The organic and inorganic ions are extracted from within the fluorapatite crystals through this ionization process which essentially allows the enamel surface to be

Study Record Dates

• First Submitted: July 10, 2026
• First Posted: July 16, 2026
• Study Start: January 10, 2026
• Primary Completion: July 10, 2026
• Study Completion (Estimated): October 1, 2026
• Last Updated: July 16, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)