Salivary Cytokines, MMP-8 and Dental Caries in Osteoporosis Patients

NCT07709247 | Not Yet Recruiting

• 1 other identifier: 2026/476
• Study Type: observational
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study examines saliva samples from patients with osteoporosis. The levels of cytokines and Matrix Metalloproteinase-8 (MMP-8) enzyme in saliva will be measured. Additionally, the dental caries status of participants will be evaluated. The aim of this study is to understand the relationship between osteoporosis and oral health. Only saliva samples will be collected from participants; no treatment or medication will be administered.

Conditions

Osteoporosis; Dental Caries; Biomarkers; Matrix Metalloproteinase 8

Outcome Measures

Primary Outcomes (1)

• Salivary Cytokine Levels

  Measurement of cytokine levels in saliva samples collected from osteoporosis patients

  day 1

Study Arms (2)

Osteoporosis Group

Patients diagnosed with osteoporosis. Saliva samples will be collected to measure cytokine levels and MMP-8.

Control Group

Healthy individuals without osteoporosis. Saliva samples will be collected for comparison.

Eligibility Criteria

• Age: 45 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients diagnosed with osteoporosis who applied to the outpatient clinic. Saliva samples and dental caries status will be evaluated. Participants will be selected according to inclusion and exclusion criteria.

You may qualify if:

• Willing to give voluntary consent For Group 1, having been diagnosed with osteoporosis For Group 2, being systemically healthy and not having a diagnosis of osteoporosis/osteopenia

You may not qualify if:

• Having a chronic inflammatory or autoimmune disease Using glucocorticoids, anti-anxiety medications, antidepressants, or antiepileptic drugs Having been diagnosed with any malignancy Having any endocrine disease Having undergone periodontal treatment within the last 6 months

Sponsors & Collaborators

• Afyonkarahisar Health Sciences University: lead

MeSH Terms

Conditions

Osteoporosis; Dental Caries

Condition Hierarchy (Ancestors)

Bone Diseases, Metabolic; Bone Diseases; Musculoskeletal Diseases; Metabolic Diseases; Nutritional and Metabolic Diseases; Tooth Demineralization; Tooth Diseases; Stomatognathic Diseases

Central Study Contacts

Kübra Karaçam, Asist.Prof.

CONTACT

+905059396258; kubrakaracam@hotmail.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: July 12, 2026
• First Posted: July 16, 2026
• Study Start: July 10, 2026
• Primary Completion (Estimated): September 30, 2026
• Study Completion (Estimated): July 10, 2027
• Last Updated: July 16, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share