Evaluation of the Salivary-free Amino Acids Levels (Glycine , Proline , Lysine , and Alanine ) With Caries Activity

NCT06953557 | Not Yet Recruiting

• 1 other identifier: Mustansiriyah
• Study Type: observational
• Target: 80
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study will be aimed to investigated the correlation between levels of salivary amino acids (glycine , proline , lysine , alanine ) in the saliva of healthy children with and without active carious lesions and to estimate the predictive capacity of caries susceptibility

Conditions

Dental Caries

Keywords

Salivary -free amino acid measurment

Outcome Measures

Primary Outcomes (1)

• Salivary-free amino acid analysis

  Unstimulated saliva collection for salivary free amino acids analysis

  Baseline :unstimulated saliva collection for salivary glycine , proline , lysine and alanine measurement

Interventions

To compare the effect of salivary glycine , proline , lysine and alanine concentration between participants with high caries activity and participants with negative caries activity DIAGNOSTIC_TEST

The investigators will measure Salivary-free amino acids by using reverse phase high performance liquid chromatography

Eligibility Criteria

• Age: 8 Years - 10 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Children in both genders in 8-10 years old

You may qualify if:

• Children aged (8,9,10) years with different caries
• Absence of signs of gingivitis or periodontal disease.

You may not qualify if:

• Children out the range of age
• Children with any systemic discases.
• Children with appliances in the mouth.
• Children with appliances in the mouth.
• Children with antibiotic treatment or any other drug over the last two weeks. B

Sponsors & Collaborators

• Al-Mustansiriyah University: lead

MeSH Terms

Conditions

Dental Caries

Condition Hierarchy (Ancestors)

Tooth Demineralization; Tooth Diseases; Stomatognathic Diseases

Central Study Contacts

Abeer Ibrahim Mohammed, B.D.S

CONTACT

+9647709497799; abeeribrahim93@uomustansiriyah.edu.iq

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Princible investigator

Study Record Dates

• First Submitted: April 15, 2025
• First Posted: May 1, 2025
• Study Start: April 30, 2025
• Primary Completion: May 30, 2025
• Study Completion: June 30, 2025
• Last Updated: May 1, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share