Hysteroscopic Findings With Histopathologic Report of Endometrium in Patients With Postmenopausal Bleeding

NCT07707570 | Not Yet Recruiting

• 1 other identifier: Soh-Med-26-6-28MS
• Study Type: observational
• Target: 90
• Locations: 0 countries
• Sites: N/A

Brief Summary

To evaluate hysteroscopic findings in women with postmenopausal bleeding and correlate them with histopathological results of the endometrium., Sohag University Hospital Obstetrics and Gynecology department

Conditions

Postmenopausal Bleeding

Keywords

postmenopausal

Outcome Measures

Primary Outcomes (1)

• evaluate hysteroscopic findings in women with postmenopausal bleeding and correlate them with histopathological results of the endometrium

  All patients in this study will be subjected to the following (as detailed in the attached patient's data sheet). I. Clinical Assessment * Detailed history including: * Duration since menopause * Pattern and duration of bleeding * Obstetric and medical history * General abdominal and pelvic examination II. Transvaginal Ultrasound (TVS) * Measurement of endometrial thickness * Assessment of uterine and adnexal pathology III. Hysteroscopic Examination Hysteroscopy will be performed using a rigid hysteroscope to evaluate: * Endometrial appearance * Presence of polyps, hyperplasia, or malignancy Hysteroscopic findings will be classified as: * Normal (proliferative, secretory, atrophic) * Abnormal (polyp, hyperplasia, carcinoma, fibroid) (1,3) Criteria suggestive of: * Hyperplasia: irregular thickened endometrium, increased vascularity (1,3) * Carcinoma: irregular necrotic tissue, atypical vessels, friable surface (1,3) IV. Endometrial Sampling • Directed biopsy will be taken from s

  2 weeks

Study Arms (1)

Postmenopausal bleeding patients

* Postmenopausal women presenting with uterine bleeding * Age ≥ 45 years

Eligibility Criteria

• Age: 45 Years+
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients in this study will be subjected to the following (as detailed in the attached patient's data sheet). I. Clinical Assessment * Detailed history including: * Duration since menopause * Pattern and duration of bleeding * Obstetric and medical history * General abdominal and pelvic examination II. Transvaginal Ultrasound (TVS) * Measurement of endometrial thickness * Assessment of uterine and adnexal pathology III. Hysteroscopic Examination Hysteroscopy will be performed using a rigid hysteroscope to evaluate: * Endometrial appearance * Presence of polyps, hyperplasia, or malignancy Hysteroscopic findings will be classified as: * Normal (proliferative, secretory, atrophic) * Abnormal (polyp, hyperplasia, carcinoma, fibroid) (1,3) Criteria suggestive of: * Hyperplasia: irregular thickened endometrium, increased vascularity (1,3) * Carcinoma: irregular necrotic tissue, atypical vessels, friable surface (1,3) IV. Endometrial Sampling • Directed biopsy will be taken from su

You may qualify if:

• Postmenopausal women presenting with uterine bleeding
• Age ≥ 45 years

You may not qualify if:

• Women on hormone replacement therapy
• Bleeding due to vulvar, vaginal, cervical, or urethral causes
• Patients on anticoagulant therapy
• Patients unfit for hysteroscopy
• Refusal to participate

Sponsors & Collaborators

• Sohag University: lead

Central Study Contacts

Mahmoud Sabri Mahmoud Mohamed Sabri Mahmoud, Resident

CONTACT

01001264613; mahmoudsabri777014@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Mahmoud Sabry Mahmoud Mohamed

Study Record Dates

• First Submitted: July 11, 2026
• First Posted: July 16, 2026
• Study Start: August 1, 2026
• Primary Completion (Estimated): January 1, 2027
• Study Completion (Estimated): August 1, 2027
• Last Updated: July 16, 2026

Record last verified: 2026-07