Comparison of Different Ventilation Modes for Reducing Kidney Motion During Retrograde Intrarenal Surgery

NCT07705646 | Not Yet Recruiting

• 1 other identifier: 21-64
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized clinical trial will compare four ventilation strategies during retrograde intrarenal surgery performed under general anesthesia. The study aims to determine whether reducing respiratory-related kidney movement improves surgical success and decreases perioperative complications. Eighty adult patients will be randomly assigned to standard ventilation, hypoventilation, intermittent apnea ventilation, or one-lung ventilation. Surgical outcomes and perioperative complications will be compared between groups.

Conditions

Kidney Stones; Nephrolithiasis

Keywords

Retrograde Intrarenal Surgery; RIRS; Mechanical Ventilatio; General Anesthesia; Kidney Motion

Outcome Measures

Primary Outcomes (1)

• Kidney Motion During Retrograde Intrarenal Surgery

  Kidney motion during surgery will be evaluated and compared among the four ventilation strategies.

  During surgery

Secondary Outcomes (6)

• Stone-free Rate

  Postoperative Day 30

• Operative Time

  During surgery

• Fluoroscopy Time

  During surgery

• Laser Activation Time

  During surgery

• Perioperative Complications

  Periprocedural

Study Arms (4)

Standard Ventilation

ACTIVE COMPARATOR

Patients will receive standard volume-controlled mechanical ventilation during retrograde intrarenal surgery under general anesthesia.

Procedure: Standard Ventilation

Hypoventilation

EXPERIMENTAL

Patients will receive hypoventilation with reduced tidal volume and respiratory rate during retrograde intrarenal surgery under general anesthesia.

Procedure: Hypoventilation

Intermittent Apnea Ventilation

EXPERIMENTAL

Patients will receive intermittent apnea periods during selected surgical steps, in coordination with the surgeon.

Procedure: Intermittent Apnea Ventilation

One-Lung Ventilation

EXPERIMENTAL

Patients will receive one-lung ventilation during selected surgical steps, in coordination with the surgeon.

Procedure: One-Lung Ventilation

Interventions

Standard Ventilation PROCEDURE

Volume-controlled mechanical ventilation using standard ventilator settings during general anesthesia.

Standard Ventilation

Hypoventilation PROCEDURE

Volume-controlled mechanical ventilation using reduced tidal volume and respiratory rate during general anesthesia.

Hypoventilation

Intermittent Apnea Ventilation PROCEDURE

Intermittent apnea periods applied during selected stages of retrograde intrarenal surgery to reduce kidney motion.

Intermittent Apnea Ventilation

One-Lung Ventilation PROCEDURE

One-lung ventilation applied during selected stages of retrograde intrarenal surgery to reduce kidney motion.

One-Lung Ventilation

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 18-75 years. ASA physical status I-III. Scheduled for elective RIRS/RIRC under general anesthesia. No obstructive or restrictive pulmonary disease. No history of pneumothorax. No pulmonary mass or other significant respiratory disease. Normal coagulation parameters and not receiving antithrombotic therapy. No active urinary tract infection. Written informed consent.

You may not qualify if:

• Age \<18 or \>75 years. ASA IV. Obstructive or restrictive pulmonary disease. History of pneumothorax. Pulmonary mass or significant respiratory disease. Receiving antithrombotic therapy or abnormal coagulation. Active urinary tract infection or urinary tract anatomical abnormality. Refusal or inability to provide informed consent.

Sponsors & Collaborators

• Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey: lead

Study Sites (1)

Sultan Abdulhamid Han Training and Research Hospital

Istanbul, Istanbul, 34668, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Kidney Calculi; Nephrolithiasis

Interventions

One-Lung Ventilation

Condition Hierarchy (Ancestors)

Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Urolithiasis; Urinary Calculi; Male Urogenital Diseases; Calculi; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Respiration, Artificial; Airway Management; Therapeutics

Study Officials

• Tuna Ertürk, MD

  University of Health Sciences Sultan 2. Abdulhamid Han Training and Research Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Tuna Ertürk, MD

CONTACT

+905325010066; tunaerturk22@yahoo.com

Hakan Emirkadı, MD

CONTACT

+905322609367; suheylaatay81@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: Participants will be randomly assigned to one of four parallel ventilation strategy groups.

Study Record Dates

• First Submitted: July 5, 2026
• First Posted: July 15, 2026
• Study Start: July 15, 2026
• Primary Completion (Estimated): November 15, 2026
• Study Completion (Estimated): November 30, 2026
• Last Updated: July 15, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)