Senescence in Myocardial Infarction

NCT07693712 | Terminated DMC

• 1 other identifier: ACU010
• Study Type: observational
• Target: 22
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators of this study have found that after a heart attack, some heart cells rapidly age (become senescent) and release proteins that make the heart disease worse. The investigators of this study would like to check for these aged-cell proteins in participants who have coronary artery bypass graft (CABG) surgery after a recent heart attack or to treat more stable heart disease. The investigators will do this by taking blood samples and a sample of normally discarded heart tissue from each group of participants. This might help tell us who is at the highest risk of developing heart disease and how people recover from a heart attack.

Conditions

Cardiovascular Diseases; Coronary Artery Disease; Myocardial Infarction; Heart Failure; Inflammation; Aging; Atherosclerosis

Outcome Measures

Primary Outcomes (1)

• Increase in senescent myocardial cells and senescence-associated secretory phenotype (SASP).

  Blood samples taken to measure expression of a range of biomarkers.

  From baseline to 6 weeks.

Secondary Outcomes (3)

• Correlation of senescence and SASP with clinical outcomes

  From baseline to 6 weeks

• Progression of chronic cardiovascular disease

  baseline to 6 weeks

• Clinical outcomes post surgery

  Baseline to 6 weeks

Study Arms (2)

Myocardial Infarction Group

Patients who are undergoing CABG surgery for Non-ST segment elevation myocardial infarction (NSTEMI)

Stable Angina Group

Patients who are undergoing CABG surgery for stable angina

Eligibility Criteria

• Age: 40 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population are male and female patients undergoing CABG surgery. There will be 70 patients split between two groups of 35 patients each. Group I will be patients who are undergoing coronary artery bypass graft surgery for recent Non-ST segment elevation myocardial infarction (NSTEMI), and Group II will be patients undergoing CABG for stable coronary artery disease

You may qualify if:

• Male and female patients aged 40 to 80 years old undergoing coronary artery bypass graft surgery for myocardial infarction or for stable angina.

You may not qualify if:

• patients with ST-elevation myocardial infarction requiring coronary angioplasty
• patients who have had previous cardiac surgery
• patients who have evidence of ongoing heart failure,
• a left ventricular ejection fraction of less than 30%
• need for pre-operative mechanical cardiac support.
• Individuals with pre-existing acute kidney injury
• Sepsis
• \>Stage 4 chronic kidney disease

Sponsors & Collaborators

• South Tees Hospitals NHS Foundation Trust: lead
• Newcastle University: collaborator

Study Sites (1)

South Tees Hospitals NHS Foundation Trust

Middlesbrough, TS4 3BW, United Kingdom

Location

Related Publications (3)

• Dookun E, Walaszczyk A, Redgrave R, Palmowski P, Tual-Chalot S, Suwana A, Chapman J, Jirkovsky E, Donastorg Sosa L, Gill E, Yausep OE, Santin Y, Mialet-Perez J, Andrew Owens W, Grieve D, Spyridopoulos I, Taggart M, Arthur HM, Passos JF, Richardson GD. Clearance of senescent cells during cardiac ischemia-reperfusion injury improves recovery. Aging Cell. 2020 Oct;19(10):e13249. doi: 10.1111/acel.13249. Epub 2020 Sep 29.

  PMID: 32996233 BACKGROUND

• Walaszczyk A, Dookun E, Redgrave R, Tual-Chalot S, Victorelli S, Spyridopoulos I, Owens A, Arthur HM, Passos JF, Richardson GD. Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction. Aging Cell. 2019 Jun;18(3):e12945. doi: 10.1111/acel.12945. Epub 2019 Mar 28.

  PMID: 30920115 BACKGROUND

• Redgrave R, Dookun E, Booth L, Folaranm O, Tual-Chalot S, Gill J, Owens A, Spyridopoulos I, Passos J, Richardson G. Senescent cardiomyocytes contribute to cardiac dysfunction following myocardial infarction. Res Sq [Preprint]. 2023 Apr 10:rs.3.rs-2776501. doi: 10.21203/rs.3.rs-2776501/v1.

  PMID: 37090497 BACKGROUND

MeSH Terms

Conditions

Cardiovascular Diseases; Coronary Artery Disease; Atherosclerosis; Myocardial Infarction; Inflammation; Heart Failure

Condition Hierarchy (Ancestors)

Coronary Disease; Myocardial Ischemia; Heart Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Study Officials

• Gavin Richardson

  Newcastle University

  PRINCIPAL INVESTIGATOR

• Enoch Akowuah

  South Tees Hospitals NHS Foundation Trust

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 8, 2024
• First Posted: July 9, 2026
• Study Start: May 8, 2024
• Primary Completion: February 26, 2026
• Study Completion: February 26, 2026
• Last Updated: July 9, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)