Effect of Exercise Training on Left Ventricular Function in Patients Post Myocardial Infarction

NCT02048696 | Completed DMC

• 1 other identifier: 13-1509
• Study Type: interventional
• Target: 26
• Locations: 1 country
• Sites: 1

Brief Summary

Patients who have suffered a heart attack are at risk of developing worsening heart function and heart failure. Exercise training has a beneficial effect on heart function and prevents heart failure. The aim of the current study is to investigate the effect of exercise training on heart function in patients who have suffered a heart attack.

Conditions

Myocardial Infarction; Heart Failure; Coronary Artery Disease

Keywords

Exercise training; High intensity interval training; left ventricular systolic function; G-protein related kinase 2; heart failure; myocardial infarction; coronary artery disease; beta adrenergic receptor

Outcome Measures

Primary Outcomes (1)

• Lymphocyte GRK2 mRNA level

  change in lymphocyte GRK2 mRNA levels

  at baseline and following 12 weeks exercise training intervention

Secondary Outcomes (9)

• Left ventricular systolic function

  at baseline and following 12 weeks exercise training intervention

• Left ventricular dimensions

  at baseline and following 12 weeks exercise training intervention

• Plasma epinephrine

  at baseline and following 12 weeks exercise training intervention

• heart rate variability

  at baseline and following 12 weeks exercise training intervention

• exercise capacity (VO2max)

  at baseline and following 12 weeks exercise training intervention

Other Outcomes (2)

• Fasting glucose

  at baseline and following 12 weeks exercise training intervention

• serum lipids

  at baseline and following 12 weeks exercise training intervention

Study Arms (2)

Exercise training

EXPERIMENTAL

Secondary prevention and cardiac rehabilitation clinic of the Montreal Heart Institute. Subjects will undergo twice weekly exercise training with high intensity interval training for a period of 12 weeks.

Other: Secondary prevention and cardiac rehabilitation clinic

control

NO INTERVENTION

Individuals in this group are offered current ACC/AHA recommendations on physical activity in patients post-myocardial infarction.

Interventions

Secondary prevention and cardiac rehabilitation clinic OTHER

Secondary prevention and cardiac rehabilitation clinic of the Montreal Heart Institute. Subjects will undergo twice weekly exercise training with high intensity interval training for a period of 12 weeks.

Exercise training

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Acute myocardial infarction
• Complete revascularization: no residual major epicardial coronary artery coronary stenosis ≥ 70%; no residual left main coronary stenosis ≥ 40%.
• Stage A-C heart failure, New York Heart Association class I-III.
• Stable dose of medications during the 4 weeks prior to enrolment.
• Able to perform a maximal cardiopulmonary stress test.
• Capacity and willingness to provide sign informed consent.

You may not qualify if:

• Pregnant
• Coronary artery bypass surgery: patients post coronary artery bypass graft exhibit wall motion abnormalities that may interfere with speckle tracking analysis.
• Incomplete revascularization with major epicardial coronary artery (left anterior descending, circumflex, or right coronary) stenosis ≥ 70%.
• Myocardial necrosis in the absence of significant flow limiting coronary artery stenosis or thrombosis, with the exception of documented STEMI and successful thrombolytic therapy resulting on no significant residual epicardial coronary artery stenosis.
• Significant valvular disease that is greater than moderate in severity
• History of non-ischemic cardiomyopathy (dilated, restrictive, infiltrative cardiomyopathy, hypertrophic, LV non compaction, or Takotsubo cardiomyopathy)
• Significant resting ECG abnormalities that preclude accurate speckle tracking.
• Paced rhythm.
• left bundle branch block
• Atrial arrhythmias (ex. persistent/permanent atrial fibrillation, atrial flutter).
• Frequent ventricular ectopics
• Significant ventricular arrhythmias (non-sustained ventricular tachycardia or syncope).
• New York Heart Association class IIIb - IV symptoms.
• Severe LV systolic dysfunction (Ejection fraction ≤ 30%)
• Active decompensated heart failure with orthopnea or paroxysmal nocturnal dyspnea.

Sponsors & Collaborators

• Montreal Heart Institute: lead

Study Sites (1)

Centre for preventive medicine and physical activity of the Montreal Heart Institute (Centre ÉPIC)

Montreal, Quebec, H1T 1N6, Canada

Location

Related Publications (2)

• Trachsel LD, Boidin M, Henri C, Fortier A, Lalonge J, Juneau M, Nigam A, Gayda M. Women and men with coronary heart disease respond similarly to different aerobic exercise training modalities: a pooled analysis of prospective randomized trials. Appl Physiol Nutr Metab. 2021 May;46(5):417-425. doi: 10.1139/apnm-2020-0650. Epub 2020 Oct 23.

  PMID: 33096006 DERIVED

• Trachsel LD, Nigam A, Fortier A, Lalonge J, Juneau M, Gayda M. Moderate-intensity continuous exercise is superior to high-intensity interval training in the proportion of VO2peak responders after ACS. Rev Esp Cardiol (Engl Ed). 2020 Sep;73(9):725-733. doi: 10.1016/j.rec.2019.09.013. Epub 2019 Dec 16. English, Spanish.

  PMID: 31837947 DERIVED

MeSH Terms

Conditions

Myocardial Infarction; Heart Failure; Coronary Artery Disease

Interventions

Secondary Prevention

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis; Coronary Disease; Arteriosclerosis; Arterial Occlusive Diseases

Intervention Hierarchy (Ancestors)

Therapeutics; Preventive Health Services; Health Services; Health Care Facilities Workforce and Services; Public Health Practice; Public Health; Environment and Public Health

Study Officials

• Anil Nigam, MD

  Montreal Heart Institute

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 22, 2014
• First Posted: January 29, 2014
• Study Start: February 1, 2014
• Primary Completion: February 1, 2016
• Study Completion: October 16, 2018
• Last Updated: October 18, 2018

Record last verified: 2018-10

Locations

CA (1)