Ozone Versus Conventional Socket Disinfection for Primary Dental Implant Stability

NCT07687680 | Active Not Recruiting

• 1 other identifier: HRU-25.18.55
• Study Type: interventional
• Target: 51
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized split-mouth controlled clinical trial aims to compare the effects of ozone and conventional implant site disinfection on primary and early secondary implant stability. Systemically healthy adults requiring at least two dental implants in symmetrical or contralateral edentulous sites will receive ozone disinfection at one implant site and conventional disinfection at the paired site according to a randomized allocation. Implant stability will be assessed immediately after implant placement using insertion torque and resonance frequency analysis (Implant Stability Quotient, ISQ), and secondary stability will be evaluated by ISQ measurements at the 3-month follow-up during healing abutment placement. The study will determine whether ozone disinfection improves implant stability during the early osseointegration period.

Conditions

Dental Implant Placement; Ozone Therapy

Keywords

Ozone therapy; Primary implant stability; Insertion torque; Socket disinfection; Osseointegration

Outcome Measures

Primary Outcomes (1)

• Primary Implant Stability (Insertion Torque)

  Primary implant stability will be assessed immediately after implant placement by measuring insertion torque (Ncm).

  Immediately after implant placement

Study Arms (2)

Ozone Disinfection

EXPERIMENTAL

Implant sites assigned to the experimental intervention receive ozone disinfection before dental implant placement.

Procedure: Ozone Implant Site Disinfection

Conventional Disinfection

EXPERIMENTAL

Implant sites assigned to the control intervention receive conventional implant site disinfection before dental implant placement.

Procedure: Conventional Socket Disinfection

Interventions

Ozone Implant Site Disinfection PROCEDURE

Before dental implant placement, the implant site assigned to the experimental intervention is disinfected using ozone according to the study protocol. In this randomized split-mouth design, each participant receives ozone disinfection at one implant site, while the paired contralateral or symmetrical implant site receives conventional disinfection. Implant stability is evaluated immediately after implant placement using insertion torque and resonance frequency analysis (ISQ), and again after 3 months using ISQ.

Ozone Disinfection

Conventional Socket Disinfection PROCEDURE

Before dental implant placement, the implant site assigned to the control intervention is disinfected using the conventional disinfection protocol. In this randomized split-mouth design, each participant receives conventional disinfection at one implant site, while the paired contralateral or symmetrical implant site receives ozone disinfection. Implant stability is evaluated immediately after implant placement using insertion torque and resonance frequency analysis (ISQ), and again after 3 months using ISQ.

Conventional Disinfection

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults aged 18 years or older.
• Systemically healthy individuals requiring at least two dental implants.
• Presence of symmetrical or contralateral edentulous sites suitable for dental implant placement.
• Adequate bone volume for implant placement without the need for simultaneous bone augmentation.
• Ability and willingness to provide written informed consent and comply with the study protocol.

You may not qualify if:

• Adults aged 18 years or older.
• Systemically healthy individuals requiring at least two dental implants.
• Presence of symmetrical or contralateral edentulous sites suitable for dental implant placement.
• Adequate bone volume for implant placement without the need for simultaneous bone augmentation.
• Ability and willingness to provide written informed consent and comply with the study protocol.

Sponsors & Collaborators

• Zeliha Başak Çakır Erdil: lead

Study Sites (1)

Faculty of Dentistry, Adıyaman University

Adıyaman, Merkez, 02030, Turkey (Türkiye)

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Research Assistant in Periodontology

Model Details: Participants are enrolled in a randomized split-mouth study design. Each participant receives both interventions at paired implant sites in symmetrical or contralateral edentulous areas. One implant site is assigned to ozone disinfection and the paired implant site to conventional disinfection before dental implant placement, allowing within-participant comparison.

Study Record Dates

• First Submitted: June 30, 2026
• First Posted: July 7, 2026
• Study Start: November 18, 2025
• Primary Completion: July 20, 2026
• Study Completion: July 20, 2026
• Last Updated: July 20, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)