Effect of Systemic Vitamin D on Dental Implant Osseointegration

NCT07684404 | Recruiting DMC

• 1 other identifier: Dental Osseointegration
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

The primary goal for any oral implantologist is to obtain satisfactory healing and long-term treatment success. Osseointegration is the key to dental implant success8 and is required to achieve direct structural and functional connection between living bone and the surface of a load-bearing artificial implant, is critical for the long-term success of dental implants. Successful dental implant therapy relies on achieving proper osseointegration, which ensures a stable structural and functional bond between the implant surface and surrounding bone. Although dental implants show a high overall success rate of around 95%.

Conditions

Dental Implant; Dental Implant Failed; Vitamin D Deficiency

Keywords

Vitamin D Deficiency; IMPLANT OSSEOINTEGRATION; Implant Failure; Factors Affect Implant Success

Outcome Measures

Primary Outcomes (2)

• Treatment of Dental Implant Osseointegration

  Evaluation of the Primary implant stability measured immediately after implant placement using the Ostell device, which assesses resonance frequency analysis (RFA) values expressed as Implant Stability Quotient (ISQ). This measurement reflects the initial mechanical stability of the implant within the bone at the time of surgery.

  3 Months

• marginal bone loss after prosthesis placement

  Marginal bone loss will be evaluated using cone beam computed tomography (CBCT) taken six months after prosthesis placement. The vertical distance between the implant shoulder and the first bone-to-implant contact will be measured on both mesial and distal aspects to assess the amount of peri-implant bone resorption over time.

  six months after proshtesis placement

Secondary Outcomes (1)

• Implant Survival Rate

  six months after prosthesis placement

Study Arms (2)

supplemental group

ACTIVE COMPARATOR

About 5 Participants will receive systemic vitamin D supplementation prior to and/or after dental implant placement. The purpose is to correct vitamin D deficiency and evaluate its effect on implant osseointegration and bone healing.

Drug: Vit D

Control Group

ACTIVE COMPARATOR

About 5 Participants will not receive vitamin D supplementation. They will undergo standard dental implant placement and follow-up care without any intervention to correct vitamin D deficiency.

Drug: Vit D

Interventions

Vit D DRUG

to address the relation between Vitamin D deficiency and Dental implant osseointegration for the identification of the participants whom may be non-responders to the vitamin D treatment

Also known as: Dental Implant

Control Group; supplemental group

Eligibility Criteria

• Age: 20 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Adults aged 20-60 with diagnosed vitamin D deficiency (\<20 ng/mL).
• Edentulous area in the posterior mandible or maxilla.
• No history of previous dental implant failure, metabolic bone diseases, or conditions affecting bone healing.
• Both genders are included

You may not qualify if:

• Severe systemic diseases that could interfere with healing.
• Patients already on vitamin D or calcium supplements.
• Smokers or patients with poor oral hygiene practices.
• Pregnant females

Sponsors & Collaborators

• Future University in Egypt: lead

Study Sites (1)

Future University in Egypt (FUE)

Cairo, New Cairo, 11511, Egypt

RECRUITING

MeSH Terms

Conditions

Vitamin D Deficiency

Interventions

Dental Implants

Condition Hierarchy (Ancestors)

Avitaminosis; Deficiency Diseases; Malnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Dental Materials; Biomedical and Dental Materials; Dental Prosthesis; Prosthodontics; Dentistry; Prostheses and Implants; Equipment and Supplies; Manufactured Materials; Technology, Industry, and Agriculture

Study Officials

• Ahmed Kamal Abo Zekry, Professor

  Oral & Maxillofacial Surgery, Future University

  STUDY CHAIR

Central Study Contacts

Rana Mohamed Abu haiba, DSC

CONTACT

+201151306588; rana.emam99@hotmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Researcher of Oral and Dental Medicine

Study Record Dates

• First Submitted: June 29, 2026
• First Posted: July 6, 2026
• Study Start: November 1, 2025
• Primary Completion (Estimated): October 20, 2026
• Study Completion (Estimated): November 1, 2026
• Last Updated: July 6, 2026

Record last verified: 2025-10

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)