Low-Level Diode Laser Therapy on the Acceleration of Osseointegration Around Delayed Dental Implant

NCT07536451 | Completed

• 1 other identifier: KFSIRB200-116
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Good quality soft tissue determines the possibility not only to obtain full primary wound closure during the bone defect reconstruction, but also assures effective implant treatment and stability of peri-implant condition.Moreover, it is very important to assure the proper emergence profile of the implant supported restorations, which give the opportunity to achieve the highest aesthetic appearance. In the long-term, the correct width and thickness of the attached keratinized tissue is the key point to ensure the stable position of the mucosal line around the implant's neck. The promising outcomes of laser on soft and hard tissue have been demonstrating in a variety of studies. Therefore, the aim of this clinical study is to evaluate the efficacy of LLDLT on enhancing osseointegration and on the peri-implant mucosal tissue around delayed dental implants.

Conditions

Dental Implant

Outcome Measures

Primary Outcomes (2)

• Change in marginal bone loss

  To assess the change in marginal bone loss, the linear distance from a fixed reference point-typically the implant shoulder or CEJ-to the highest level of bone-to-tooth/implant contact is measured.

  2 weeks, 1month, 2 months, and 6 months

• Change in in implant stability

  Ostell device will be used to assess implant stability

  Immediately after surgery, 2 months and 6months postoperative.

Secondary Outcomes (1)

• Change in bone density

  2 weeks, 1month, 2 months, and 6 months

Study Arms (2)

With laser

EXPERIMENTAL

Other: Dental implant + LLDL

Without laser

ACTIVE COMPARATOR

Other: Dental implant

Interventions

Dental implant + LLDL OTHER

implant placement in the posterior areas and implants will be placed with application of LLDL. Preparation of the alveolus for delayed dental implant placement will be done and LLDL application according to manufacturer instructions

With laser

Dental implant OTHER

It includes ten patients seeking for implant placement at the posterior areas and those patients will be received their implants only without application of LLDL .

Without laser

Eligibility Criteria

• Age: 20 Years - 50 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Patients are systemically medically free.
• Ability to maintain good oral hygiene as evidenced in recall visits.
• Sufficient mesiodistal and interocclusal space and have an intact buccal bone contours which does not require bone augmentation procedures.
• Adequate bone quality.
• Keratinized tissue ≥ 2mm.
• Thickness of the gingiva ≥ 1 mm.

You may not qualify if:

• Presence of any systemic disease that could influence the outcome of the therapy.
• Presence of any risk factor e.g.; smoker, pregnant, lactating patients or any disease affect bone healing.
• Previous history of periodontal surgical treatment in quadrant selected for the study.
• Restorations or caries in the area to be treated and non-vital tooth.
• Adjacent teeth are tilted or rotated.
• Patients taking medications known to cause affect bone quality.
• Traumatic occlusion or Para-functional habits such as clenching or bruxism.
• Participation in other clinical trials.

Sponsors & Collaborators

• Hams Hamed Abdelrahman: lead

Study Sites (1)

Kafr El-sheikh University

Kafr Elsheikh, Egypt

Location

MeSH Terms

Interventions

Dental Implants

Intervention Hierarchy (Ancestors)

Dental Materials; Biomedical and Dental Materials; Dental Prosthesis; Prosthodontics; Dentistry; Prostheses and Implants; Equipment and Supplies; Manufactured Materials; Technology, Industry, and Agriculture

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Lecturer of Dental Public Health and biostatistical consultanat

Study Record Dates

• First Submitted: April 11, 2026
• First Posted: April 17, 2026
• Study Start: June 1, 2024
• Primary Completion: October 1, 2025
• Study Completion: October 1, 2025
• Last Updated: April 17, 2026

Record last verified: 2026-04

Locations

EG (1)