Trials Sponsors Conditions Drugs Pricing

Conditions

TMJ Disc Displacement With Reduction

Keywords

TMJDisc Displacement With ReductionArthrocentesisHyaluronic AcidI-PRF

Outcome Measures

Primary Outcomes (2)

Intensity of pain
Pain intensity will be evaluated subjectively using Numeric Rating Scale from zero to 10 zero indicates no pain at all 10 indicates the worst pain ever
preoperative, one week, one month, 3 months and 6 months
Maximum interincisal opening, lateral and protrusive movements
1. Maximum interincisal opening: the distance in millimeters between the incisal edges of the central incisors in vertical direction at maximum pain free mouth opening, measured using a caliper. 2. Range of lateral and protrusive movements: the distance in millimeters between the upper and lower midlines in horizontal direction on lateral and protrusive movements, measured using a caliper.
preoperative, one week, one month, 3 months and 6 months

Secondary Outcomes (1)

Clicking
preoperative, one week, one month, 3 months and 6 months

Study Arms (4)

Group I: Arthrocentesis only

ACTIVE COMPARATOR

Procedure: 18 joints that receive arthrocentesis using 100 ml of ringer lactate solution

Group II: Arthrocentesis followed by hyaluronic acid injection

ACTIVE COMPARATOR

Procedure: Arthrocentesis followed by hyaluronic acid injection

Group III: Arthrocentesis followed by injection of hyaluronic acid and betamethasone mixture

ACTIVE COMPARATOR

Procedure: Arthrocentesis followed by injection of hyaluronic acid and betamethasone mixture

Interventions

18 joints that receive arthrocentesis using 100 ml of ringer lactate solutionProcedure

18 joints that receive arthrocentesis using 100 ml of ringer lactate solution

Group I: Arthrocentesis only

Arthrocentesis followed by hyaluronic acid injectionProcedure

18 joints that receive arthrocentesis using 100 ml of ringer lactate solution followed by intra-articular injection of 1 ml of hyaluronic acid

Registry intervention entries

These entries preserve how the registry describes the intervention. Their treatment roles are shown separately from molecular identities.

Grouped treatment entry
Arthrocentesis followed by injection of hyaluronic acid and betamethasone mixture
The registry names several treatments. This does not confirm that participants received them together or that they form a single product.
View registry record

Eligibility Criteria

Age18 Years - 45 Years

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64)

You may qualify if:

Age: 18 - 45 years.
Patients with disc displacement with reduction in any of the TMJs.

Sponsors & Collaborators

Mansoura University
Otherlead

Study Sites (1)

Faculty of Dentistry Mansoura University

Al Mansurah, Egypt

RECRUITING

Faculty of Dentistry Mansoura UniversityCONTACT0020502267151 dentfac@mans.edu.eg

Study Officials

Nada Hamed
Faculty of Dentistry Mansoura University
PRINCIPAL INVESTIGATOR

Central Study Contacts

Nada Hamed

CONTACT

00201119659235 hamednada99@mans.edu.eg

Study Design

Study Type: interventional
Phase: not applicable
Allocation: RANDOMIZED
Masking: SINGLE
Who Masked: OUTCOMES ASSESSOR
Purpose: TREATMENT
Intervention Model: PARALLEL
Sponsor Type: OTHER
Responsible Party: SPONSOR

Study Record Dates

First Submitted

June 29, 2026

First Posted

July 6, 2026

Study Start

January 6, 2026

Actual (reported)

Primary Completion

December 2026

Estimated

Planned date reported by the registry; this milestone is not confirmed as achieved.

Hyaluronic Acid and I-PRF Mixture for TMJ Disc Displacement Management

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (2)

Secondary Outcomes (1)

Study Arms (4)

Group I: Arthrocentesis only

Group II: Arthrocentesis followed by hyaluronic acid injection

Group III: Arthrocentesis followed by injection of hyaluronic acid and betamethasone mixture

Interventions

Registry intervention entries

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

Group IV: Arthrocentesis followed by injection of hyaluronic acid and I-PRF mixture

You may not qualify if:

Data Sharing

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (2)

Secondary Outcomes (1)

Study Arms (4)

Group I: Arthrocentesis only

Group II: Arthrocentesis followed by hyaluronic acid injection

Group III: Arthrocentesis followed by injection of hyaluronic acid and betamethasone mixture

Interventions

Registry intervention entries

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

Group IV: Arthrocentesis followed by injection of hyaluronic acid and I-PRF mixture

You may not qualify if:

Data Sharing

Source record

Locations