Trials Sponsors Conditions Drugs Pricing

Conditions

TMJ Disc Displacement With Reduction

Outcome Measures

Primary Outcomes (1)

Severity of pain
severity of pain is measured by Visual analog scale (VAS) From (0-10) Where 0: no pain 10: worst pain
baseline and at 6 months

Study Arms (2)

painful cases with disc displacement with reduction

ACTIVE COMPARATOR

painful cases of disc displacement with reduction

EXPERIMENTAL

Other: hypertonic saline 5% sodium chloride

Interventions

hypertonic saline 5% sodium chlorideOther

Hypertonic saline acts as an analgesic by alleviating nociceptive pain from inflamed tissues, which may include bone, connective tissue , synovium , or a combination of these Hypertonic saline results in safe and remarkable outcomes on knee pain, stiffness and function compared with intra-articular dextrose injection

painful cases of disc displacement with reduction

hypertonic dextrose 20%Other

A recent study showed the sensorineural analgesic effect of 5% dextrose prolotherapy in the treatment of chronic low back pain ,Therefore, the mechanism of action for dextrose prolotherapy is hypothesized to work through reducing peripheral sensitization and targeting structural dysfunction

Eligibility Criteria

Age15 Years - 75 Years

Sexall

Healthy VolunteersNo

Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

presence of one or more of the following observations in one or both temporomandibular joints:
pain.

Sponsors & Collaborators

Cairo University
Otherlead

Related Publications (3)

Gibaly A, Abdelmoiz M, Alghandour AN. Evaluation of the effect of dextrose prolotherapy versus deep dry needling therapy for the treatment of temporomandibular joint anterior disc displacement with reduction: (a randomized controlled trial). Clin Oral Investig. 2024 Aug 8;28(9):475. doi: 10.1007/s00784-024-05830-z.
PMID: 39115583BACKGROUND
Mohammed MR, Hamad SA, Al-Dawoody AD, Shehab AA, Ahmed OS. Effect of dextrose prolotherapy on internal derangement of the temporomandibular joint. Eur Rev Med Pharmacol Sci. 2023 Jun;27(11):4883-4889. doi: 10.26355/eurrev_202306_32605.
PMID: 37318462BACKGROUND

MeSH Terms

Interventions

Saline Solution, HypertonicSodium Chloride

Intervention Hierarchy (Ancestors)

Hypertonic SolutionsSolutionsPharmaceutical PreparationsChloridesHydrochloric AcidChlorine CompoundsInorganic ChemicalsSodium Compounds

Central Study Contacts

aya allah gamal salah, bachelors degree

CONTACT

+20 1005557843 ayaallah.gamal@dentistry.cu.edu.eg

Study Design

Study Type: interventional
Phase: not applicable
Allocation: RANDOMIZED
Masking: SINGLE
Who Masked: CARE PROVIDER
Purpose: TREATMENT
Intervention Model: PARALLEL
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Aya Allah Gamal

Study Record Dates

First Submitted

February 17, 2025

First Posted

February 21, 2025

Study Start

August 20, 2025

Estimated (date passed)

This estimate has passed. The registry has not confirmed an actual date for this milestone.

Primary Completion

Therapeutic Effect of Using Injectable Hypertonic Saline 5% Versus Injectable Dextrose 20% on Pain in Painful Cases of Disc Displacement With Reduction

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (1)

Study Arms (2)

painful cases with disc displacement with reduction

painful cases of disc displacement with reduction

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Related Publications (3)

MeSH Terms

Interventions

Intervention Hierarchy (Ancestors)

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (1)

Study Arms (2)

painful cases with disc displacement with reduction

painful cases of disc displacement with reduction

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Related Publications (3)

MeSH Terms

Interventions

Intervention Hierarchy (Ancestors)

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record