Patterns of Aortic Isthmus Doppler in Early Fetal Growth Restriction , and the Changes in Aortic Isthmus Doppler Parameters With Every Changes of Other Early Iugr Parameters Like EFW, Uterine Artery Doppler, Cerebroplacental Ratio and Ductus Venosus Doppler in Comparison With Normal Group .

NCT07676708 | Not Yet Recruiting

• 1 other identifier: HannaMSc-E-iugr-2026
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study aims to evaluate the patterns of aortic isthmus Doppler in fetuses diagnosed with early fetal growth restriction (FGR) and to correlate these findings with the severity of FGR and other Doppler parameters. A cross-sectional comparative observational study will be conducted on singleton pregnant women attending the fetal medicine unit at Assiut University Hospital. Participants will be divided into two groups: fetuses with FGR and normal controls. Doppler measurements including aortic isthmus indices, uterine artery, umbilical artery, middle cerebral artery, cerebroplacental ratio, and ductus venosus will be assessed at a single time point. The study will help to clarify the clinical value of aortic isthmus Doppler in early detection and assessment of fetal compromise in FGR cases.

Conditions

Fetal Growth Restriction; Placental Insufficiency; Aortic Isthmus Doppler; Cerebroplacental Ratio

Outcome Measures

Primary Outcomes (1)

• Aortic Isthmus Pulsatility Index

  Measurement of the aortic isthmus pulsatility index (PI) and its correlation with the severity of fetal growth restriction based on estimated fetal weight percentiles.

  Day 1

Secondary Outcomes (4)

• Cerebroplacental Ratio

  Day 1

• Ductus Venosus Doppler

  Day 1

• Uterine and Umbilical Artery Doppler

  Day 1

• Isthmic Flow Index

  1 day

Study Arms (2)

FGR Group

Singleton pregnancies diagnosed with fetal growth restriction (estimated fetal weight less than the 10th percentile for gestational age), undergoing Doppler assessment including aortic isthmus and other fetal vessels.

Control Group

Singleton pregnancies with normal fetal growth (estimated fetal weight above the 10th percentile), undergoing the same Doppler assessment as the FGR group for comparison.

Eligibility Criteria

• Age: 18 Years - 45 Years
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Singleton pregnant women attending the fetal medicine unit at Women's Health Hospital, Assiut University, including both fetal growth restriction cases and normal controls.

You may qualify if:

• Singleton pregnancy
• Diagnosis of fetal growth restriction (estimated fetal weight \<10th percentile for gestational age)
• Written informed consent obtained from the patient

You may not qualify if:

• Major fetal structural anomalies, especially cardiovascular anomalies
• Multiple pregnancy (e.g., twins)
• Suspected chromosomal abnormalities or genetic syndromes
• Severe maternal comorbidities affecting Doppler results (e.g., uncontrolled diabetes, lupus)
• Uncertain gestational age
• Fetal demise before Doppler assessment

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Fetal Growth Retardation; Placental Insufficiency

Condition Hierarchy (Ancestors)

Fetal Diseases; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Growth Disorders; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Placenta Diseases

Central Study Contacts

Hanna Matt Louize, Specialist

CONTACT

+201287618565; hanna.matta0155@med.aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Obestetric and gynaecology specialist, Fetal and maternal ultrasound as subspecialty

Study Record Dates

• First Submitted: June 22, 2026
• First Posted: June 30, 2026
• Study Start: July 1, 2026
• Primary Completion (Estimated): June 1, 2028
• Study Completion (Estimated): June 1, 2029
• Last Updated: June 30, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share