Evaluation of OMEGA-3 Effect in Alveolar Socket Preservation in Aesthetic Zone

NCT07665918 | Completed DMC

• 1 other identifier: 30122024
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

To evaluate the effect of Omega-3 in preserving bone after extraction

Conditions

Omega-3 Fatty Acids; Socket Preservation; Esthetic Zone

Keywords

Omega-3; Socket preservation; Atraumatic extraction; Esthetic zone; Extraction socket; Implant

Outcome Measures

Primary Outcomes (1)

• Post-operative pain

  Visual Analogue Scale score "VAS score" From 0-10 scores score 0 is no pain which is the best 1-4 is mild pain 5 is moderate pain from 5 -10 pain is getting worse and 10 is the worst

  immediately after extraction and the second day after extraction

Secondary Outcomes (5)

• Radiographic bone changes "horizontal bone changes " using Cone beam CBCT

  before extraction and 3months after omega 3 placement

• Radiographic bone changes " Vertical bone fill" using CBCT

  before and after 3 months of extraction and omega-3 placement

• Radiographic bone changes "Bone density" using CBCT

  3 months after extraction and placement of omega-3

• Histological examination

  after 3months of extraction during implant placement bone is taken using trephine bur

• Healing Index "HI" by Landry et al using scores

  after 3months of omega 3 placement

Study Arms (1)

Atraumatic extraction for single rooted teeth and placement of omega-3 in the socket

EXPERIMENTAL

Atraumatic extraction for single rooted teeth in anterior zone and omega-3 polyunsaturated fatty acid placed with collagen sponge inside the extraction socket for socket preservation and implant placement

Dietary Supplement: Omega 3 Fish Oil supplements

Interventions

Omega 3 Fish Oil supplements DIETARY_SUPPLEMENT

omega-3 fatty acid supplement

Also known as: Omega-3

Atraumatic extraction for single rooted teeth and placement of omega-3 in the socket

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients with non-restorable remaining roots.
• Patients free of systemic conditions that might affect the surgical procedure or the quantity or quality of bone (uncontrolled hypertension, uncontrolled diabetes).

You may not qualify if:

• Patients below 18 years old
• Patients with hypersensitivity to omega-3, drug formulations or allergic to seafood.
• Pregnant or lactating females
• Patients undergoing chemotherapy or radiotherapy
• Smokers

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Faculty of Dentistry

Cairo, Egypt

Location

Related Links

• Polyunsaturated fatty acids and its effect on inflammation

MeSH Terms

Interventions

Docosahexaenoic Acids

Intervention Hierarchy (Ancestors)

Fatty Acids, Omega-3; Dietary Fats, Unsaturated; Dietary Fats; Fats; Lipids; Fatty Acids, Unsaturated; Fatty Acids; Fish Oils; Oils

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: General practitioner Masters Degree Candidate

Study Record Dates

• First Submitted: May 27, 2026
• First Posted: June 24, 2026
• Study Start: January 1, 2025
• Primary Completion: October 24, 2025
• Study Completion: October 25, 2025
• Last Updated: June 24, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)