NCT07664774

Brief Summary

Hypertension remains a significant global health challenge, often requiring lifelong management. While pharmacological treatments are standard, there is increasing interest in non-pharmacological interventions like resonant breathing. This technique, characterized by slow, rhythmic breathing at 4.5-7 breaths per minute, is thought to lower blood pressure by enhancing parasympathetic activity and restoring autonomic balance.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
50

participants targeted

Target at P25-P50 for not_applicable hypertension

Timeline
Completed

Started Apr 2025

Shorter than P25 for not_applicable hypertension

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 17, 2025

Completed
8 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 17, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 17, 2025

Completed
12 days until next milestone

First Submitted

Initial submission to the registry

December 29, 2025

Completed
6 months until next milestone

First Posted

Study publicly available on registry

June 24, 2026

Completed
Last Updated

June 24, 2026

Status Verified

June 1, 2026

Enrollment Period

8 months

First QC Date

December 29, 2025

Last Update Submit

June 23, 2026

Conditions

Hypertension

Keywords

Blood PressureHeart RateHypertensionPerceived Stress Resonant Breathing

Outcome Measures

Primary Outcomes (3)

  • Blood pressure

    Blood pressure will be measured using a cuff wrapped around your upper arm.

    8 week

  • heart rate

    To measure heart rate, find your pulse on your wrist or neck, count beats for 15 or 30 seconds, then multiply to get beats per minute (bpm)

    8 week

  • perceived stress

    Perceived Stress Scale (PSS) scoring involves answering 10 (or 14/4) questions on a 0 (never) to 4 (very often) scale, then reversing scores for specific items (4, 5, 7, 8 for PSS-10) before summing them to get a total score (0-40 for PSS-10), with higher scores meaning more perceived stress, generally falling into low (0-13), moderate (14-26), and high (27-40) categories, though it's a self-assessment tool, not a diagnostic one.

    8 week

Study Arms (2)

Experimental Group

EXPERIMENTAL

Group A: Will undergo a traditional physical therapy exercise program along with an eight-week resonant breathing program, with 20 minutes of supervised practice, three times a week.

Combination Product: Resonant breathing

Control group

PLACEBO COMPARATOR

Group B: Will continue with the baseline physiotherapy intervention (general warm-up exercises and stretching) throughout the study period, with no resonant breathing or specific breathing exercises included.

Combination Product: Resonant breathing

Interventions

Resonant breathingCOMBINATION_PRODUCT

Resonant breathing, or Coherent Breathing, is a slow, rhythmic technique focusing on equal inhales and exhales (often 5-6 seconds each) to calm the nervous system, improve heart rate variability (HRV), and reduce stress by aligning breath with heart rhythms.

Control groupExperimental Group

Eligibility Criteria

Age30 Years - 65 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Adults age 30-65 years
  • Patients with hypertension stage I
  • Patients with no serious comorbidities
  • Not currently in any breathing therapy or rehabilitation programs

You may not qualify if:

  • Age under 30 or over 65
  • Patients with severe hypertension (stage II or III)
  • Patients with serious comorbidities
  • Patients taking medicines affecting blood pressure or heart rate
  • Current use of tobacco or materials that may have an effect on blood pressure or stress level

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Different Commuinty Center in Lahore

Lahore, Punjb, Pakistan

Location

Related Publications (2)

  • Spruill TM. Chronic psychosocial stress and hypertension. Curr Hypertens Rep. 2010 Feb;12(1):10-6. doi: 10.1007/s11906-009-0084-8.

    PMID: 20425153BACKGROUND

  • Scott SB, Whitehead BR, Bergeman CS, Pitzer L. Combinations of stressors in midlife: examining role and domain stressors using regression trees and random forests. J Gerontol B Psychol Sci Soc Sci. 2013 May;68(3):464-75. doi: 10.1093/geronb/gbs166. Epub 2013 Jan 22.

    PMID: 23341437BACKGROUND

MeSH Terms

Conditions

Hypertension

Condition Hierarchy (Ancestors)

Vascular DiseasesCardiovascular Diseases

Study Officials

  • Maryum Khan, MS

    Riphah International University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: 2
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

December 29, 2025

First Posted

June 24, 2026

Study Start

April 17, 2025

Primary Completion

December 17, 2025

Study Completion

December 17, 2025

Last Updated

June 24, 2026

Record last verified: 2026-06

Data Sharing

IPD Sharing
Will not share

Locations

PA(1)