Isometric and Dynamic Handgrip Training Effects on Hypertension

NCT06601738 | Completed

• 1 other identifier: Arisha Noor
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Essential hypertension accounts for 13 percent of total deaths worldwide, accounting for one of the major risk factors. Hypertension (high blood pressure) is when the pressure in your blood vessels is too high (140/90 mmHg or higher). Dynamic exercises, sustained hand grip contractions elicit lower systolic blood pressure and heart rate responses. So for patients undergoing exercise therapy, low intensity isometric exercises are preferable. Significant reduction is seen in mean arterial blood pressure and systolic blood pressure in individuals conducting isometric for 8 weeks in 30%. The reduction in systolic blood pressure will be clinically significant. The main objective of this study will be to determine the effects of dynamic and isometric handgrip exercise training on cardiovascular parameters in hypertensive patients Grade 1 hypertensive patients are included as per AHA and JNC7 criteria. A sample of 100 hypertensive patients will be recruited and divided into two treatment groups; G1: dynamic exercise in hypertensive patients, and G2: isometric exercise in hypertensive patients. Outcome measure will include systolic blood pressure, diastolic blood pressure, mean arterial blood pressure and pulse pressure. Outcome measures will be assessed at baseline and 2nd and 4th weeks posttreatment.

Conditions

Hypertension

Keywords

Systolic Blood Pressure; Diastolic Blood Pressure; Mean Arterial Blood Pressure; Pulse Pressure

Outcome Measures

Primary Outcomes (2)

• 6 Minute Walk test

  It is a standard method for measuring exercise capacity in patients with cardiopulmonary disease such as PAH. The 6MWT measures how far a patient can walk in 6 minutes. Walking is an activity performed every day by most patients except for those most severely limited. By assessing patients\' ability to exercise, the 6MWT provides a global assessment of respiratory, cardiovascular, neuromuscular, and cognitive function. The 6MWT does not differentiate what limits the patient nor does it assess maximal exercise capacity. Instead, the 6MWT allows the patient to exercise at a daily functional level and is a useful tool for assessing severity of disease, and increasing walk distance correlates with a subjective improvement in dyspnea

  Baseline; 4nd Week; 8th Week

• Blood Pressure Measurements (SBP & DBP)

  An appropriately sized cuff for the arm circumference was installed on the non-dominant arm. Blood pressure was measured every 20 minutes by 24 hours, and awake and sleep periods were determined according to information provided by the patients, the following are 7 strategies recommended by the AHA/AMA for accurate attainment of BP: 1) no conversation, 2) empty bladder, 3) use correct cuff size, 4) place BP cuff on bare arm, 5) support arm at heart level, 6) keep legs uncrossed, and 7) support back and feet

  Baseline; 4nd Week; 8th Week

Study Arms (2)

Group A

EXPERIMENTAL

Other: Isomeric Hand Grip Exercises

Group B

ACTIVE COMPARATOR

Other: Dynamic Hand Grip Exercises

Interventions

Isomeric Hand Grip Exercises OTHER

Patients will be instructed to squeeze and sustain the dynamometer for 2 min at 30% M.V.C. The dynamometer pointer which read the scale provided visual feedback to the subjects for the maintenance of the 30% M.V.C. This procedure will be repeated twice for each training session with a 5-minute rest in between.

Group A

Dynamic Hand Grip Exercises OTHER

Dynamic handgrip exercise was performed with both-sided, metronome-guided rhythmic hand contractions for 2min. The handgrip ring, closest to 20% of MVC, was chosen for DHE which was performed at a frequency of 30/min, acoustically indicated by a metronome beat.

Group B

Eligibility Criteria

• Age: 30 Years - 55 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Gender (both)
• Age (30-55 years)
• Grade 1 hypertensive patients as per AHA and JNC7 criteria

You may not qualify if:

• Patients having hypertension associated due to other diseases.
• Patients having joint problems of wrist, hand fingers, ligament and tendon injuries of hand and fingers.
• Patients having recent hand surgeries, fracture, history of arthritis, carpal tunnel syndrome.
• Patient having history of any symptoms of chest pain.
• Patients having loss of consciousness during physical activity.

Sponsors & Collaborators

• Riphah International University: lead

Study Sites (1)

Riphah Rehabiliation Clinic

Lahore, Punjab Province, 54770, Pakistan

Location

Related Publications (7)

• Oliveira-Silva L, Fecchio RY, Silva Junior NDD, Pio-Abreu A, Silva GVD, Drager LF, Silva de Sousa JC, Forjaz CLM. Post-dynamic, isometric and combined resistance exercise responses in medicated hypertensive men. J Hum Hypertens. 2024 Jan;38(1):52-61. doi: 10.1038/s41371-023-00859-1. Epub 2023 Sep 5.

  PMID: 37670145 BACKGROUND

• Ogbutor GU, Nwangwa EK, Uyagu DD. Isometric handgrip exercise training attenuates blood pressure in prehypertensive subjects at 30% maximum voluntary contraction. Niger J Clin Pract. 2019 Dec;22(12):1765-1771. doi: 10.4103/njcp.njcp_240_18.

  PMID: 31793486 BACKGROUND

• Cahu Rodrigues SL, Farah BQ, Silva G, Correia M, Pedrosa R, Vianna L, Ritti-Dias RM. Vascular effects of isometric handgrip training in hypertensives. Clin Exp Hypertens. 2020;42(1):24-30. doi: 10.1080/10641963.2018.1557683. Epub 2019 Jan 9.

  PMID: 30626217 BACKGROUND

• Punia S, Kulandaivelan S. Home-based isometric handgrip training on RBP in hypertensive adults-Partial preliminary findings from RCT. Physiother Res Int. 2020 Jan;25(1):e1806. doi: 10.1002/pri.1806. Epub 2019 Aug 16.

  PMID: 31418966 BACKGROUND

• Polito MD, Papst R, Goessler K. Twelve weeks of resistance training performed with different number of sets: Effects on maximal strength and resting blood pressure of individuals with hypertension. Clin Exp Hypertens. 2021 Feb 17;43(2):164-168. doi: 10.1080/10641963.2020.1833024. Epub 2020 Oct 10.

  PMID: 33043697 BACKGROUND

• Kappus RM, Bunsawat K, Brown MD, Phillips SA, Haus JM, Baynard T, Fernhall B. Effect of oxidative stress on racial differences in vascular function at rest and during hand grip exercise. J Hypertens. 2017 Oct;35(10):2006-2015. doi: 10.1097/HJH.0000000000001433.

  PMID: 28594709 BACKGROUND

• Fecchio RY, de Sousa JCS, Oliveira-Silva L, da Silva Junior ND, Pio-Abreu A, da Silva GV, Drager LF, Low DA, Forjaz CLM. Effects of dynamic, isometric and combined resistance training on blood pressure and its mechanisms in hypertensive men. Hypertens Res. 2023 Apr;46(4):1031-1043. doi: 10.1038/s41440-023-01202-4. Epub 2023 Feb 9.

  PMID: 36759659 BACKGROUND

MeSH Terms

Conditions

Hypertension

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases

Study Officials

• Arisha Noor, MS*

  Riphah International University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 16, 2024
• First Posted: September 19, 2024
• Study Start: August 30, 2024
• Primary Completion: December 30, 2024
• Study Completion: January 30, 2025
• Last Updated: June 15, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)