The Prevalence of Hyperglycemia in Surgical Patients With Pre-diabetes

NCT07662980 | Not Yet Recruiting

• 1 other identifier: REB26-0116
• Study Type: observational
• Target: 750
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this study is to measure the prevalence and risks of hyperglycemia in surgical patients with prediabetes. The main questions it aims to answer are:

• What is the prevalence of hyperglycemia in surgical patients with prediabetes?
• What is the relative risk of postoperative complications associated with hyperglycemia? To answer these questions, surgical patients with prediabetes will undergo universal glucose measurement in the perioperative period. Glucose data will be analyzed in conjunction with electronic health record (EHR) data describing patient outcomes.

Conditions

Prediabetes or Diabetes; Surgery Complications; Non-Cardiac/ Non-Thoracic Surgery; Stress Hyperglycemia

Keywords

Prediabetes; Prevalence; Surgical Complications; Perioperative Hyperglycemia

Outcome Measures

Primary Outcomes (1)

• Prevalence of perioperative hyperglycemia

  Prediabetes will be defined as described in Section 4.2 using Diabetes Canada definitions. The perioperative period will include the day of surgery and the early postoperative period. The day of surgery includes surgical admitting, intraoperative, and recovery room on postoperative day (POD) 0, which is the day that surgery was completed until 23:59. The early postoperative period will be defined as the first 3 full postoperative days, in keeping with studies that have demonstrated that hyperglycemia is most common in the first 72 hours after surgery and that early hyperglycemia is associated with greater 30-day postoperative mortality. Hyperglycemia will be defined using Diabetes Canada reference ranges as any glucose value \>10.0 mmol/L by any form of glucose measurement.

  Up to the first 3 postoperative days or discharge, whichever comes first.

Secondary Outcomes (1)

• Post-operative complications

  Within 30 days of surgery.

Study Arms (1)

Surgical Patients with Prediabetes

Adult patients undergoing non-cardiac surgeries who have pre-diabetes.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Surgical in-patients at the Foothills Medical Centre.

You may qualify if:

• Hemoglobin A1c measurement between 6 and 6.4%
• Scheduled for non-cardiac surgery

You may not qualify if:

• Age\>18
• Pregnancy
• Any formal diabetes diagnosis
• Current use of medications that influence blood glucose regardless of the indication
• Undergoing cardiac, intracranial neurosurgery, bariatric, or pancreatic surgeries

Sponsors & Collaborators

• University of Calgary: lead

Study Sites (1)

Foothills Medical Centre

Calgary, Alberta, Canada

Location

Related Publications (1)

• Ruzycki SM, Harrison TG, Lithgow KC, Cameron A, Philp L, Heatlie L, Esmail R, Ejaredar M, Helmle K, McKeen J, Dillane D. Day-of-surgery quality gaps in glycemic management: a retrospective cohort study. Perioper Med (Lond). 2025 Nov 25;14(1):143. doi: 10.1186/s13741-025-00628-3.

  PMID: 41291884 BACKGROUND

Related Links

• This website describes the processes outlined a prior quality improvement project designed and implemented by our team. This study follows similar through lines to the present study, as we will be using the same systems and personnel.

MeSH Terms

Conditions

Prediabetic State; Diabetes Mellitus

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Study Officials

• Shannon Ruzycki, MD

  University of Calgary

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Shannon Ruzycki, MD

CONTACT

+1 (403) 604-1642; shannon.ruzycki@ucalgary.ca

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 30 Days
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: February 23, 2026
• First Posted: June 23, 2026
• Study Start (Estimated): May 1, 2027
• Primary Completion (Estimated): May 1, 2028
• Study Completion (Estimated): May 1, 2028
• Last Updated: June 23, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF
• Time Frame: Data will be available after analyses have completed, approximately in the month of March, 2028. Data will be retained in accordance with the University of Calgary's Master Records Retention Schedule(MaRRS). During this time period, data will be available upon reasonable request.

Locations

CA (1)