Stress Hyperglycemia and Acute Ischemic Stroke

NCT04408768 | Completed

• 1 other identifier: El Zaiton Specialized Hospital
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Whereas diabetes mellitus is clearly a risk factor for the occurrence of stroke and for its poor prognosis, hyperglycemia per se is also linked to increased morbidity and mortality in stroke patients.Therefore, the objective of this work was to study the glycemic status of acute ischemic stroke patients and to assess its impact on stroke outcome.

Conditions

Stress Hyperglycemia

Outcome Measures

Primary Outcomes (1)

• National Institutes of Health Stroke Scale (NIHSS)

  The NIHSS score categorized into: no stroke symptoms (0), mild stroke (1-4), moderate stroke (5-15), moderate to severe stroke (16-20), and sever (21-42)

  30 days

Secondary Outcomes (1)

• 30-days mortality

  30 days

Study Arms (2)

Normal RBS

Normal RBS on ICU admission and controlled blood sugar within 24 hours

Other: standard protocol for stroke patients

High RBS

High RBS on ICU admission and uncontrolled blood sugar during first 24 hours

Other: standard protocol for stroke patients

Interventions

standard protocol for stroke patients OTHER

Standard protocol for stroke patients

Also known as: no specific intervention

High RBS; Normal RBS

Eligibility Criteria

• Age: 50 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

This study included eighty acute ischemic stroke patients who presented within 24 hours of onset of symptoms. They were equally divided into two groups; group A included patients with normal (70-150 mg/dl) RBS on ICU admission and controlled blood sugar within 24 h, while group B included those with high RBS on ICU admission and uncontrolled blood sugar during first 24 h.

You may qualify if:

• Acute ischemic stroke within 24 hours of onset of symptoms

You may not qualify if:

• subdural hematoma
• Transient ischemic attack
• Subarachnoid hemorrhage
• Hemorrhagic stroke
• Major comorbidities Hyperglycemia on admission that was controlled (random blood sugar (RBS) \< 150 mg/dl) within 24 hours with insulin therapy, diabetic
• Ketoacidosis
• RBS less than 70 mg/dl on admission

Sponsors & Collaborators

• Ain Shams University: lead

Study Sites (1)

Hanaa El Gendy

Cairo, Ain Shams University Specialized Hospital, Egypt

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: May 26, 2020
• First Posted: May 29, 2020
• Study Start: May 17, 2018
• Primary Completion: July 9, 2019
• Study Completion: August 20, 2019
• Last Updated: June 1, 2020

Record last verified: 2020-05

Locations

EG (1)