Perioperative Predictive Value of Physical Activity on Short- and Long-term Morbidity and Mortality

NCT07603622 | Recruiting

• 1 other identifier: PeriopPrePA Karolinska
• Study Type: observational
• Target: 50,000
• Locations: 1 country
• Sites: 1

Brief Summary

Over 300 million surgeries are performed globally every year. Complications after surgery - infections, cardiovascular conditions, postoperative pulmonary complications and renal impairment - affect survival and quality of life. Age and co-morbidity are unmodifiable factors, contributing to increased risk of these perioperative complications. However, a modifiable risk factor is physical activity. This study aims to test if self reported physical activity has added predicted value, beyond established risk factors, for predicting perioperative morbidity and mortality.

Conditions

Anesthesia; Surgery; Surgery Complications

Keywords

Perioperative medicine; Outcome; Mortality; Morbidity

Outcome Measures

Primary Outcomes (1)

• Mortality

  Death within the time frames described below

  [Time Frame: Mortality will be recorded at 30, 60, 90 and 365 days after index surgery]

Secondary Outcomes (2)

• DAH30 (Days At Home alive at 30 days)

  30 days after index surgery

• DAH365 (Days At Home alive at 365 days)

  365 days after index surgery

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adult patients (equal to or over 18 years) undergoing elective non-cardiac surgery at the two study sites, Karolinska University Hospital Solna and Karolinska University Hospital Huddinge

You may qualify if:

• Adult patients (equal to or over 18 years) undergoing elective non-cardiac surgery at the two study sites, Karolinska University Hospital Solna and Karolinska University Hospital Huddinge

You may not qualify if:

• Patients under the age of 18, transplant, day surgery, acute surgery, anesthesia monitoring, brachy therapy and gamma knife interventions. In case of multiple surgeries, only the first will be included.

Sponsors & Collaborators

• Karolinska Institutet: lead

Study Sites (1)

Karolinska Institutet

Stockholm, Sweden

RECRUITING

Central Study Contacts

Max Bell, MD, PhD

CONTACT

+46708278533; max.bell@regionstockholm.se

Arman Valadkhani, MD, PhD

CONTACT

+46812370000; arman.valadkhani@regionstockholm.se

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, PhD

Study Record Dates

• First Submitted: May 18, 2026
• First Posted: May 22, 2026
• Study Start: May 1, 2026
• Primary Completion (Estimated): October 31, 2026
• Study Completion (Estimated): November 30, 2026
• Last Updated: May 22, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

SE (1)