Physical Activity and Cardiometabolic Health in Women With or Without Polycystic Ovary Syndrome (SCOPAP)

NCT07659392 | Not Yet Recruiting

• 2 other identifiers: RBHP 2026 BRUGNON2026-A00712-49
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The primary objective of this study is to investigate the effects of a multidisciplinary intervention, including a targeted adapted physical activity program, on lipid oxidation during a walking exercise in women with overweight or obesity, with or without polycystic ovary syndrome. Specifically, the study aims to compare changes in lipid oxidation before and after the intervention between women with polycystic ovary syndrome and those without polycystic ovary syndrome. The secondary objectives are to assess the impact of polycystic ovary syndrome on several physiological and metabolic parameters in women with overweight or obesity. These include: (i) resting energy metabolism; (ii) resting blood pressure and heart rate; (iii) energy expenditure, energy cost, and heart rate during a walking exercise; (iv) body composition, glycemic and lipid profiles, and circulating levels of sex hormones and adipokines; (v) movement behaviors; and (vi) physical fitness. In addition, the effect of the multidisciplinary intervention, including the adapted physical activity program, will be evaluated on these same outcomes: (i) resting energy metabolism; (ii) resting blood pressure and heart rate; (iii) energy expenditure, energy cost, and heart rate during walking exercise; (iv) body composition, glycemic and lipid profiles, and concentrations of sex hormones and adipokines; (v) movement behaviors; and (vi) physical fitness, in women with overweight or obesity, with or without polycystic ovary syndrome.

Conditions

Poly Cystic Ovary Syndrome; Overweight , Obesity

Keywords

polycystic ovary syndrome; women; cardiometabolic; Physical activity

Outcome Measures

Primary Outcomes (1)

• Lipid oxidation during walking exercise

  Baseline and after 10 weeks of intervention

Secondary Outcomes (38)

• Energy expenditure at rest

  Baseline and after 10 weeks of intervention

• Lipid oxidation at rest

  Baseline and after 10 weeks of intervention

• Carbohydrate oxidation at rest

  Baseline and after 10 weeks of intervention

• Systolic blood pressure at rest

  Baseline and after 10 weeks of intervention

• Diastolic blood pressure at rest

  Baseline and after 10 weeks of intervention

Study Arms (1)

Physical activity intervention

EXPERIMENTAL

Behavioral: Physical activity

Interventions

Physical activity BEHAVIORAL

Participants will participate to adapted physical activity, supervised by a professional

Physical activity intervention

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Women aged 18 to 40 years (inclusive boundaries)
• Women with a body mass index (BMI) between 25 and 40 kg/m²
• Women performing no more than 150 minutes of moderate-to-vigorous physical activity per week
• Women able to provide informed consent to participate
• Women affiliated with a social security system
• One group will consist of women with polycystic ovary syndrome, and another group will consist of women without polycystic ovary syndrome

You may not qualify if:

• Pregnancy or breastfeeding, as declared by the participant
• Postmenopausal women
• Women currently receiving pharmacological treatment for obesity or who have received such treatment within the past two years
• Women under legal protection measures (guardianship, curatorship, or judicial protection)
• Refusal to sign the informed consent form

Sponsors & Collaborators

• University Hospital, Clermont-Ferrand: lead
• SMR Nutrition Obésité UGECAM: collaborator
• Laboratoire AME2P: collaborator

Study Sites (1)

CHU de Clermont-Ferrand

Clermont-Ferrand, 63000, France

Location

MeSH Terms

Conditions

Overweight; Obesity; Polycystic Ovary Syndrome; Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Ovarian Cysts; Cysts; Neoplasms; Ovarian Diseases; Adnexal Diseases; Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Diseases; Gonadal Disorders; Endocrine System Diseases; Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Central Study Contacts

Lise Laclautre

CONTACT

+33473754963; promo_interne_drci@chu-clermontferrand.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: The participants will have different conditions, with or without polycystic ovary syndrome, but will follow the same intervention

Study Record Dates

• First Submitted: June 11, 2026
• First Posted: June 22, 2026
• Study Start: July 1, 2026
• Primary Completion (Estimated): December 1, 2028
• Study Completion (Estimated): December 1, 2028
• Last Updated: June 22, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)