Energy Profile and Low Intensity Activity (PROFILE)

NCT04864028 | Completed

• 2 other identifiers: RBHP 2020 DUCLOS 32020-A03311-38
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

The recent literature has highlighting the importance of the time of SB and the level of physical activity (PA) as predictors of metabolic cardio risks. Now, sedentary lifestyles are well recognized as one of the causes of mortality. As with physical activity, a dose-response relationship appears to exist: mortality would increase with time spent in sedentary behaviors. However, this relationship would not be linear: the more the daily sitting time increases, the more the consequences on mortality are important. It is now well demonstrated that time spent in sedentary adult behaviour finds primarily its origin in the work, characterized by prolonged and uninterrupted periods of sitting. Many strategies have been settled to break the prolonged sitting time. The most promising one seem to be the use of active workstations (standing, walking, cycling, stepping) because they reduce sedentary time at work and increase physical activity with positive effects on the global health. However inter variability in energy response have been identified during a sit to stand allocation with subject "savers" profile showing an increase in energy expenditure while others categorized as "non-savers" increased significantly their energy expenditure between sitting and standing position. As others active workstation strategies exist, this study aim to first, better characterize energy response to posture and activity allocation (15min sit-15min stand-15min sit-15min low intensity cycling), secondly to identify parameters that could explain different energy profile.

Conditions

Healthy

Keywords

Active workstation; cycling; energy expenditure; sedentary

Outcome Measures

Primary Outcomes (1)

• energy expenditure

  Using an indirect calorimetry device change in energy expenditure will be assed during the 1h posture /activity allocation (15min sitting, 15min standing, 15min sitting, 15 min low intensity cycling)

  change from baseline to the experimental visit (Day 1)

Secondary Outcomes (8)

• physical activity level (ActiGraph)

  during the 7 days following the experimental session

• physical activity level (ActivPAL)

  during the 7 days following the experimental session

• Body composition : fat mass and fat free mass

  day 0

• upper limb strength

  during the experimental session after energy expenditure assessment (Day 1)

• aerobic fitness

  during the experimental session after energy expenditure assessment (day 1)

Study Arms (1)

Healthy volunteer

EXPERIMENTAL

Other: physical activity

Interventions

physical activity OTHER

15min sitting, 15min standing, 15min sitting, 15 min low intensity cycling

Healthy volunteer

Eligibility Criteria

• Age: 20 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy volunteer, male or female, between 18 and 61 years old
• Body mass index \> 18,5 kg/m2 and ≤ 25 kg/m2
• Able to provide informed consent to research participation
• Registered in the French social security system

You may not qualify if:

• Subject using a sit-to-stand office desk or a swiss ball
• Contact jobs (face-to-face with people)
• Pregnant or breastfeeding women
• Medical or surgical history determined by principal investigator to be not compatible with the study
• Subject with cardiorespiratory and/or osteo-articular disorders limiting their ability to perform physical tests or the use of active offices
• Subject with type 1 or type 2 diabetes treated with insulin
• Subject with progressive cardiovascular or neoplastic disease.
• Subject with known neuromuscular pathology: myopathy, myasthenia, rhabdomyolysis, paraplegia, hemiplegia

Sponsors & Collaborators

• University Hospital, Clermont-Ferrand: lead
• Laboratory AME2P UR3533: collaborator
• Université d'Auvergne: collaborator

Study Sites (1)

CHU de Clermont-Ferrand

Clermont-Ferrand, 63000, France

Location

MeSH Terms

Conditions

Sedentary Behavior

Interventions

Exercise

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Martine Duclos

  University Hospital, Clermont-Ferrand

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 9, 2021
• First Posted: April 28, 2021
• Study Start: May 25, 2021
• Primary Completion: December 12, 2022
• Study Completion: June 29, 2023
• Last Updated: July 10, 2023

Record last verified: 2023-07

Locations

FR (1)