Cardiovascular Abnormalities in Children With Attention-deficit/Hyperactivity Disorder

NCT07655843 | Not Yet Recruiting

• 1 other identifier: ADHD
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

To identify the prevalence and types of cardiovascular abnormalities in children diagnosed with ADHD

Conditions

ADHD - Combined Type

Keywords

cardiovascular abnormalities

Outcome Measures

Primary Outcomes (3)

• prevalence of ECG and echocardiographic abnormalities in children with ADHD.

  The percentage of children diagnosed with Attention-Deficit/Hyperactivity Disorder (ADHD) who exhibit one or more predefined structural or functional cardiac abnormalities on electrocardiogram (ECG) or transthoracic echocardiography (Echo). Abnormalities will be defined as: ECG Abnormalities: Prolonged corrected QT interval (QTc \> 450\\text{ ms} for males, \> 460\\text{ ms} for females using Bazett's formula), pathologic T-wave inversions, conduction blocks (e.g., right bundle branch block), or arrhythmias (e.g., ventricular premature beats). Echocardiographic Abnormalities: Left ventricular hypertrophy, structural congenital heart defects, valvular regurgitation (mitral/tricuspid) graded as moderate or severe, or reduced systolic function (Left Ventricular Ejection Fraction \< 55\\%). All assessments will be performed by a single blinded investigator using standard pediatric clinical guidelines to ensure consistency

  within one week of emrollment

• systolic blood pressure

  Comparison of systolic blood pressure (measured via a standard automated pediatric sphygmomanometer) across the study groups. Unit of Measure: Millimeters of mercury (mmHg)

  within one week of enrollment

• diastolic blood pressure

  Comparison of systolic blood pressure (measured via a standard automated pediatric sphygmomanometer) across the study groups. Unit of Measure: Millimeters of mercury (mmHg)

  within one week of enrollment

Secondary Outcomes (1)

• body mass index

  within one week of enrollment

Study Arms (2)

case group

: consisting of pediatric patients previously diagnosed with ADHD according to DSM/5 criteria currently receiving pharmacological treatment.

Diagnostic Test: echocardiography and ECG

control group

composed of age and sex matched neurotypical children

Diagnostic Test: echocardiography and ECG

Interventions

echocardiography and ECG DIAGNOSTIC_TEST

* Electrocardiography (ECG): Twelve-lead ECG will be taken using 12A ECG device . * Echocardiographic Measurements M-Mode echocardiographic measurements clinical history and examination

case group; control group

Eligibility Criteria

• Age: 6 Years - 18 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Participants will be divided into: * A case group: consisting of pediatric patients previously diagnosed with ADHD according to DSM/5 criteria currently receiving pharmacological treatment. * A control group: composed of age and sex matched neurotypical children.

You may qualify if:

• Case group :
• Age is \> 6 years and \<18 years old
• Both sex
• Patients diagnosed as having ADHD according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria.
• Currently receiving pharmacological treatment for at least six months
• Control group:
• Healthy, typically developing children , matched by age and sex to the case group

You may not qualify if:

• Age \> 18 years
• Patients who have a history of chronic diseases.
• Patients with established hereditary syndromes or chromosomal abnormalities as Down syndrome.

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Cardiovascular Abnormalities

Interventions

Echocardiography; Electrocardiography

Condition Hierarchy (Ancestors)

Cardiovascular Diseases; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Intervention Hierarchy (Ancestors)

Cardiac Imaging Techniques; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Ultrasonography; Heart Function Tests; Diagnostic Techniques, Cardiovascular; Electrodiagnosis

Central Study Contacts

Ahmed A Ahmed Allam, MBBCH

CONTACT

01063146513; Ahmed.16266349@med.aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: resident

Study Record Dates

• First Submitted: June 4, 2026
• First Posted: June 18, 2026
• Study Start: June 15, 2026
• Primary Completion (Estimated): October 15, 2027
• Study Completion (Estimated): April 15, 2028
• Last Updated: June 18, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share