Personality Traits and Biochemical Risk Phenotypes

NCT07653048 | Recruiting

• 1 other identifier: PHEBiP-2/2024
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective observational study investigates the association between personality traits and routine laboratory abnormalities in adults undergoing routine health assessment. Personality traits are assessed using the Five-Factor Personality Inventory (FFPI), while biochemical data are obtained from routine laboratory testing, including markers of glycemic status, liver function, lipid metabolism, renal function, and complete blood count parameters. The primary objective of the study is to evaluate the association between FFPI personality trait scores and the total number of laboratory abnormalities identified during routine clinical evaluation. Secondary analyses will examine associations between personality traits and glycemic status, fasting plasma glucose concentration, liver function markers, lipid profile parameters, renal function indicators, complete blood count parameters, and the total number of laboratory abnormalities. The findings may contribute to a better understanding of the relationship between psychological characteristics and biological health indicators and may support the development of more personalized approaches to health promotion, risk assessment, and disease prevention.

Conditions

Prediabetes; Hyperglycemia; Metabolic Syndrome

Keywords

Personality Traits; Biomarkers; Prediabetes; Hyperglycemia; Occupational Health; Five-Factor Personality Inventory; Laboratory Abnormalities; Routine Health Assessment

Outcome Measures

Primary Outcomes (1)

• Number of Laboratory Abnormalities

  Total number of routine laboratory parameters outside their corresponding reference intervals, expressed as a count of abnormal laboratory findings. Laboratory parameters include fasting plasma glucose (mg/dL), gamma-glutamyl transferase (GGT, U/L), alanine aminotransferase (ALT, U/L), aspartate aminotransferase (AST, U/L), total cholesterol (mg/dL), serum creatinine (mg/dL), urea (mg/dL), estimated glomerular filtration rate (eGFR, mL/min/1.73 m²), and complete blood count parameters measured according to standard laboratory units.

  At baseline

Secondary Outcomes (2)

• Five-Factor Personality Inventory (FFPI) Scores

  At baseline

• Glycemic Status

  At baseline

Study Arms (1)

Routine Health Assessment Cohort

This cohort includes adults undergoing routine health assessment who complete the Five-Factor Personality Inventory (FFPI) and have biochemical laboratory data available from routine clinical evaluation. Collected variables include indicators of glycemic status, liver function, lipid metabolism, renal function, and complete blood count parameters obtained during routine laboratory assessment. Participants undergo routine laboratory assessment, and the total number of laboratory abnormalities is determined based on the count of laboratory parameters outside the corresponding reference intervals. These data are used to evaluate associations between personality traits and biological health indicators.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adults undergoing routine health assessment in a clinical setting who complete the Five-Factor Personality Inventory (FFPI) and have routine laboratory data available for evaluation of laboratory health indicators and their association with personality traits.

You may qualify if:

• Adults aged 18 years or older
• Undergoing routine health assessment
• Completion of the Five-Factor Personality Inventory (FFPI)
• Availability of routine laboratory test results
• Provision of written informed consent

You may not qualify if:

• Age younger than 18 years
• Incomplete FFPI assessment
• Missing or incomplete laboratory data
• Refusal or inability to provide informed consent

Sponsors & Collaborators

• Medical Center TOPMED: lead
• George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures: collaborator

Study Sites (1)

Medical Center TOPMED

Târgu Mureş, Mureș County, 540058, Romania

RECRUITING

MeSH Terms

Conditions

Prediabetic State; Hyperglycemia; Metabolic Syndrome

Condition Hierarchy (Ancestors)

Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Insulin Resistance; Hyperinsulinism

Study Officials

• Stefania Diana St Nilca, Principal Psychologist, PhD St

  George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Stefania Diana St Nilca, Principal Psychologist, PhD St

CONTACT

+40745404037; diana.nilca@umfst.ro

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 8, 2026
• First Posted: June 17, 2026
• Study Start: October 1, 2024
• Primary Completion (Estimated): January 1, 2027
• Study Completion (Estimated): September 1, 2027
• Last Updated: June 17, 2026

Record last verified: 2026-06

Locations

RO (1)