Effects of Postprandial Walking and Resistance Snacking on Glucose Responses in Adults With Metabolic Syndrome

NCT07620886 | Not Yet Recruiting

• 2 other identifiers: SNU-CGM-EX-20262601/001-020
• Study Type: interventional
• Target: 25
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study will examine whether light physical activity after meals can improve 24-hour glucose responses in adults with metabolic syndrome and prediabetes. Participants will complete three experimental conditions in a randomized crossover order: prolonged sitting, 15 minutes of postprandial walking, and brief resistance exercise snacks consisting of squats and calf raises performed every 20 minutes during the postprandial period. Continuous glucose monitoring will be used to assess 24-hour glucose responses, and heart rate variability will be measured during the 2-hour postprandial period to evaluate acute autonomic responses. The main outcome is 24-hour mean glucose derived from continuous glucose monitoring.

Conditions

Metabolic Syndrome; Prediabetes

Keywords

Continuous glucose monitoring; Postprandial glucose; Exercise snack; Resistance exercise; Heart rate variability; Prediabetes; Metabolic syndrome

Outcome Measures

Primary Outcomes (1)

• 24-hour mean glucose

  Mean glucose over 24 hours after each experimental condition, derived from continuous glucose monitoring.

  24 hours after each experimental condition

Secondary Outcomes (2)

• 2-hour postprandial glucose incremental area under the curve

  0 to 120 minutes after the standardized meal

• Change in RMSSD

  0 to 120 minutes after the standardized meal

Study Arms (3)

Prolonged Sitting

NO INTERVENTION

Participants will remain seated during the 2-hour postprandial period after consuming a standardized meal.

Postprandial Walking

EXPERIMENTAL

Participants will perform 15 minutes of light-to-moderate walking after consuming a standardized meal.

Behavioral: Postprandial walking

Brief Resistance Exercise Snacks

EXPERIMENTAL

Participants will perform 3-minute bouts of body-weight resistance exercises, including squats and calf raises, every 20 minutes during the postprandial period after consuming a standardized meal.

Behavioral: Brief resistance exercise snacks

Interventions

Postprandial walking BEHAVIORAL

Participants will perform 15 minutes of light-to-moderate walking after consuming a standardized meal. Walking intensity will be monitored using heart rate and rating of perceived exertion.

Postprandial Walking

Brief resistance exercise snacks BEHAVIORAL

Participants will perform 3-minute bouts of body-weight resistance exercises every 20 minutes during the postprandial period after consuming a standardized meal. The exercise bouts will include squats and calf raises.

Brief Resistance Exercise Snacks

Eligibility Criteria

• Age: 40 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults aged 40 to 65 years
• Presence of metabolic syndrome
• Fasting glucose of 100 mg/dL or higher or HbA1c of 5.7% or higher
• Not regularly engaged in structured exercise training, defined as less than 150 minutes per week during the past year
• Able to consume the standardized study meals
• Able to wear a continuous glucose monitor and a chest strap heart rate monitor
• Able to provide written informed consent

You may not qualify if:

• History of major cardiovascular, cerebrovascular, respiratory, renal, hepatic, neurological, or other severe medical conditions that may affect study participation.
• Uncontrolled hypertension, defined as systolic blood pressure ≥160 mmHg or diastolic blood pressure ≥100 mmHg.
• Current use of medications associated with a high risk of hypoglycemia, such as insulin or sulfonylureas.
• Initiation or dose change of insulin or oral glucose-lowering medications within the past 3 months.
• Initiation or dose change of medications for hypertension, dyslipidemia, or diabetes within the past 3 months.
• Musculoskeletal, neurological, or orthopedic conditions that limit safe participation in walking or body-weight resistance exercise, including severe knee, hip, back, or ankle pain.
• Regular participation in moderate-to-vigorous exercise of 150 minutes or more per week during the past year.
• Difficulty consuming the standardized study meals, including food allergy, dietary restrictions, or severe gastrointestinal symptoms.
• Difficulty wearing a continuous glucose monitor or history of severe skin irritation or allergy to adhesive sensors.
• Difficulty wearing a chest strap heart rate monitor or skin problems at the chest strap site.
• Pregnancy or planned pregnancy.
• Acute illness, infection, surgery, or hospitalization within the past month.
• Current participation in another interventional study.
• Any condition judged by the investigator to make participation unsafe or inappropriate.

Sponsors & Collaborators

• Seoul National University: lead

MeSH Terms

Conditions

Metabolic Syndrome; Prediabetic State

Condition Hierarchy (Ancestors)

Insulin Resistance; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Diabetes Mellitus; Endocrine System Diseases

Central Study Contacts

Yunmin Han

CONTACT

+82-10-3537-2339; hym224@snu.ac.kr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: Masking is not feasible because participants and investigators will be aware of the assigned exercise condition.
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: Participants will complete three experimental conditions in a randomized crossover order: prolonged sitting, 15 minutes of postprandial walking, and brief resistance exercise snacks performed every 20 minutes during the postprandial period. Each participant will serve as his or her own control.

Study Record Dates

• First Submitted: May 27, 2026
• First Posted: June 2, 2026
• Study Start: June 15, 2026
• Primary Completion (Estimated): September 1, 2026
• Study Completion (Estimated): October 1, 2026
• Last Updated: June 2, 2026

Record last verified: 2026-05