Perioperative Myocardial Injury in Patients Undergoing Coronary Artery Bypass Grafting: A Prospective Clinical Study

NCT07650487 | Not Yet Recruiting

• 1 other identifier: PMICABG
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

Perioperative myocardial injury (PMI) following coronary artery bypass grafting (CABG) is associated with postoperative morbidity, mortality, and long-term outcomes. High-sensitivity troponin assays and cardiac MRI offer reliable diagnostic tools for PMI, but evidence regarding optimal diagnostic thresholds and perioperative imaging strategy is limited. This prospective clinical study aims to determine the incidence of perioperative myocardial injury using multimodal assessments including high-sensitivity troponin, electrocardiogram, echocardiography, cardiac MRI, and perioperative cardiovascular events.

Conditions

Myocardial Injury; Coronary Artery Disease

Keywords

Perioperative Myocardial Injury; Coronary Artery Bypass Grafting; Cardiac MRI; hs-Troponin; Coronary Artery Disease

Outcome Measures

Primary Outcomes (1)

• Incidence of Perioperative Myocardial Injury (PMI)

  Perioperative myocardial injury defined by elevation of high-sensitivity troponin above the 99th percentile upper reference limit together with new myocardial injury detected by cardiac MRI or supportive ECG/echocardiographic changes. PMI is assessed using laboratory testing and imaging performed preoperatively, within 48 hours post-CABG, and at discharge.

  Within 48 hours post-CABG

Study Arms (1)

CABG Patients

A prospective cohort of adult patients undergoing elective or urgent coronary artery bypass grafting. Participants will undergo perioperative evaluation including hs-troponin testing, ECG, echocardiography, and cardiac MRI to assess perioperative myocardial injury.

Diagnostic Test: High-Sensitivity Troponin; Diagnostic Test: Cardiac MRI

Interventions

High-Sensitivity Troponin DIAGNOSTIC_TEST

High-sensitivity troponin levels are measured preoperatively, predischarge, and at 6-month follow-up to assess perioperative myocardial injury.

CABG Patients

Cardiac MRI DIAGNOSTIC_TEST

A diagnostic assessment panel including high-sensitivity troponin testing, electrocardiography, echocardiography, and cardiac magnetic resonance imaging performed during the perioperative period.

CABG Patients

Eligibility Criteria

• Age: 21 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adult patients diagnosed with unstable angina and scheduled to undergo isolated coronary artery bypass grafting (CABG) at the Second Hospital of Jilin University. All participants receive routine perioperative clinical evaluations. The study includes patients aged 21 years or older who provide written informed consent and have had no major cardiovascular events within the previous 6 months. Patients with severe organ dysfunction, pregnancy, or contraindications to cardiac MRI are excluded.

You may qualify if:

• Age ≥ 21 years
• Undergoing CABG for unstable angina
• Able to provide written informed consent
• No major cardiovascular event in the prior 6 months

You may not qualify if:

• Significant hepatic, renal, or other major organ dysfunction
• Pregnancy or breastfeeding
• Withdrawal during the study
• Contraindication to cardiac MRI (metal implants, claustrophobia, etc.)

Sponsors & Collaborators

• Second Hospital of Jilin University: lead

Study Sites (1)

the Second Hospital of Jilin University

Changchun, Jilin, 130000, China

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Residual clinical samples collected as part of routine perioperative care may be used for measuring high-sensitivity troponin and other laboratory indicators. No samples will be stored long-term and no DNA will be collected.

MeSH Terms

Conditions

Coronary Artery Disease

Condition Hierarchy (Ancestors)

Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: June 10, 2026
• First Posted: June 16, 2026
• Study Start: July 1, 2026
• Primary Completion (Estimated): June 30, 2027
• Study Completion (Estimated): July 30, 2027
• Last Updated: June 16, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)