Spinal Alignment, Spinal Mobility, and Balance in Patients With Multiple Sclerosis

NCT07648277 | Recruiting

• 1 other identifier: 08/1456
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system characterized by demyelination and axonal degeneration. Neuromuscular impairments associated with MS, including muscle weakness, spasticity, fatigue, and proprioceptive deficits, may lead to alterations in spinal posture and reduced spinal mobility. These changes can negatively affect trunk control, balance, respiratory function, and functional independence. Although postural abnormalities and mobility limitations have been reported in individuals with MS, the relationship between spinal posture, spinal mobility, and balance remains insufficiently investigated. Therefore, this study aims to examine the associations between spinal posture, spinal mobility, and balance performance in individuals with multiple sclerosis. Improved understanding of these relationships may contribute to the development of targeted rehabilitation interventions aimed at enhancing postural control and functional outcomes in this population. This study further hypothesises that alterations in spinal posture and spinal mobility are associated with impaired balance performance in individuals with multiple sclerosis.

Conditions

Multiple Sclerosis; Balance

Outcome Measures

Primary Outcomes (2)

• Spinal alignment

  Spinal alignment was assessed in the sagittal and frontal planes during neutral standing, maximal trunk flexion, and maximal trunk extension. All spinal alignment parameters were recorded as angular values and expressed in degrees (°).

  1 hour

• Spinal mobility

  Spinal mobility was assessed in both the sagittal and frontal planes. In the sagittal plane, mobility was calculated as the angular difference between the neutral standing posture and maximal trunk flexion and extension positions. In the frontal plane, lateral flexion mobility was calculated as the angular difference between the neutral standing posture and maximal right and left lateral flexion positions. All measurements were recorded in degrees (°).

  1 hour

Secondary Outcomes (2)

• Single-Leg Stance

  1 hour

• Time Up and Go

  1 hour

Study Arms (1)

Multiple Sclerosis

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Neurologist-confirmed diagnosis of relapsing-remitting multiple sclerosis (RRMS)

You may qualify if:

• Diagnosis of relapsing-remitting multiple sclerosis (RRMS)
• Aged between 18 and 65 years
• EDSS score between 0.5 and 4.5
• Standardized Mini-Mental State Examination score ≥24

You may not qualify if:

• Receipt of corticosteroid treatment within the previous 4 weeks
• Presence of any additional neurological disorder
• Spasticity defined as a Modified Ashworth Scale score ≥3
• History of surgical intervention involving the lower extremities, spine, or abdominal region

Sponsors & Collaborators

• Ankara Yildirim Beyazıt University: lead

Study Sites (1)

Ankara Yıldırım Beyazıt University

Ankara, Çubuk, 06760, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Multiple Sclerosis

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Target Duration: 2 Years
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 10, 2026
• First Posted: June 15, 2026
• Study Start: February 1, 2026
• Primary Completion: June 12, 2026
• Study Completion (Estimated): June 30, 2026
• Last Updated: June 15, 2026

Record last verified: 2026-06

Locations

TU (1)