Evaluation of Different Non-Invasive Methods in the Treatment of Dentin Hypersensitivity Associated With Non-Carious Cervical Lesions: A Split-Mouth Clinical Study

NCT07648147 | Not Yet Recruiting

• 2 other identifiers: Dentin Hypersensivity18920
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this split-mouth clinical study is to compare the effectiveness of D Blue diode laser application and ProSylc bioactive glass powder application in reducing dentin hypersensitivity in patients with non-carious cervical lesions (NCCLs). Different treatment modalities will be applied within the same participant, and changes in dentin hypersensitivity will be evaluated following treatment. The primary outcome measure will be the reduction in dentin hypersensitivity after the interventions. The findings of this study are expected to contribute to the identification of effective non-invasive treatment approaches for the management of dentin hypersensitivity associated with non-carious cervical lesions.

Conditions

Non-Carious Cervical Lesions (NCCLs); Dentin Hypersensitivity

Keywords

Non-Carious Cervical Lesions; Dentin Hypersensitivity; Diode Laser; D Blue Diode Laser; Bioactive Glass; ProSylc; Split-Mouth Study; Non-Invasive Treatment

Outcome Measures

Primary Outcomes (1)

• Change in Dentin Hypersensitivity

  Dentin hypersensitivity will be assessed using a Visual Analog Scale (VAS) following standardized air stimulus application. The change in VAS scores from baseline to follow-up visits will be evaluated.

  Baseline, immediately after treatment, 1 week, 1 month, and 3 months

Study Arms (2)

D Blue Diode Laser Group

EXPERIMENTAL

Teeth assigned to this group will receive D Blue diode laser application for the management of dentin hypersensitivity associated with non-carious cervical lesions.

Device: D Blue Diode Laser

ProSylc Bioactive Glass Group

EXPERIMENTAL

Teeth assigned to this group will receive ProSylc bioactive glass powder application for the management of dentin hypersensitivity associated with non-carious cervical lesions.

Device: ProSylc Bioactive Glass Powder

Interventions

D Blue Diode Laser DEVICE

D Blue diode laser application for the treatment of dentin hypersensitivity associated with non-carious cervical lesions.

Also known as: Diode Laser

D Blue Diode Laser Group

ProSylc Bioactive Glass Powder DEVICE

ProSylc bioactive glass powder application for the treatment of dentin hypersensitivity associated with non-carious cervical lesions.

Also known as: Bioactive Glass Powder

ProSylc Bioactive Glass Group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Individuals aged between 18 and 65 years. Systemically healthy individuals. Individuals with dentin hypersensitivity. Presence of two permanent teeth with similar severity of dentin hypersensitivity in the same participant.
• Participants who agree to participate in the study and sign the informed consent form

You may not qualify if:

• Presence of active caries in the study teeth. Presence of cervical restoration in the study teeth. Presence of pulpal pathology. History of desensitizing treatment within the last 3 months. Pregnancy. Presence of systemic disease. Use of analgesics within the last 48 hours.

Sponsors & Collaborators

• Cukurova University: lead

Study Sites (1)

Çukurova University

Adana, sarıçam, 01250, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Dentin Sensitivity

Interventions

Lasers, Semiconductor

Condition Hierarchy (Ancestors)

Tooth Diseases; Stomatognathic Diseases

Intervention Hierarchy (Ancestors)

Lasers; Optical Devices; Equipment and Supplies; Radiation Equipment and Supplies

Central Study Contacts

Hüsna Selinay S Dağdelen, Doctor of Dental Medicine

CONTACT

+905453051080; selinay428@gmail.com

Ezgi S Sonkaya Akburak, Associate Professor Doctor

CONTACT

+905054974631; sonkayaezgi@yahoo.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research Assistant

Model Details: This study will employ a split-mouth design in which each participant will receive both interventions on different eligible teeth. One side will be treated with D Blue diode laser, while the contralateral side will receive ProSylc bioactive glass powder application. This design allows direct comparison of treatment outcomes within the same individual and minimizes inter-individual variability.

Study Record Dates

• First Submitted: June 10, 2026
• First Posted: June 15, 2026
• Study Start (Estimated): July 20, 2026
• Primary Completion (Estimated): December 20, 2026
• Study Completion (Estimated): January 20, 2027
• Last Updated: June 15, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)