Laser Therapy for Dentin Hypersensitivity

NCT07431736 | Active Not Recruiting

• 1 other identifier: E-61749811-000-4041535
• Study Type: interventional
• Target: 25
• Locations: 1 country
• Sites: 1

Brief Summary

A 12-Month Comparative Clinical Evaluation of the Efficacy of Er,Cr:YSGG Laser Irradiation, Remin Pro Application, and Their Combined Therapy in the Treatment of Dentin Hypersensitivity.

Conditions

Dentin Hypersensitivity

Keywords

Er,Cr;YSGG Laser; Remin Pro

Outcome Measures

Primary Outcomes (1)

• Visual Analog Scale

  Subjective pain perception is evaluated using a 100-mm Visual Analog Scale (VAS) ranging from '0 = No pain' to '10 = Worst pain imaginable.' Participants mark their perceived pain intensity on the scale following a 1-second air blast stimulus to the cervical area. The score is measured in millimeters from the zero anchor, with higher values indicating greater pain severity.

  From baseline to 12 month

Secondary Outcomes (1)

• Schiff Cold Air Sensitivity Scale

  From baseline to 12 month

Study Arms (3)

Er,Cr;YSGG Laser

EXPERIMENTAL

The Er,Cr:YSGG laser (WaterLase iPlus) operates at 2780 nm, targeting water and hydroxyapatite for minimally invasive treatment. It reduces dentin hypersensitivity through coagulation, recrystallization, and bio-stimulation, while minimizing thermal damage and micro-cracks compared to conventional tools. This study evaluates the long-term individual and synergistic efficacy of this laser protocol combined with remineralizing agents to address gaps in the current literature regarding combined treatment modalities.

Device: Er,Cr;YSGG Laser, Waterlase, Biolase Technology Inc., Irvine, CA, ABD

Remin Pro, a hydroxyapatite-containing remineralizing agent

EXPERIMENTAL

Remin Pro (VOCO, Cuxhaven, Germany) is a desensitizing paste composed of hydroxyapatite, sodium fluoride, and xylitol. Its therapeutic mechanism is primarily attributed to the physical occlusion of patent dentinal tubules by hydroxyapatite. Additionally, sodium fluoride facilitates remineralization and enhances acid resistance, whereas xylitol contributes to the reduction of plaque formation through its antimicrobial properties. This combination is applied to provide both symptomatic relief and surface protection for hypersensitive dentin.

Device: Remin Pro (VOCO, Cuxhaven, Germany)

Combined Therapy: Er,Cr:YSGG Laser + Remin Pro

EXPERIMENTAL

Subjects in this arm receive a sequential combined treatment protocol. First, the hypersensitive dentin surface is irradiated with the Er,Cr:YSGG laser (WaterLase iPlus) using the parameters defined in the laser-only group (0.25 W, 20 Hz, 50 mJ, non-contact mode). Immediately following the laser application, Remin Pro paste is applied to the target area using a micro-brush for 30 seconds. This approach is designed to utilize the synergistic effects of laser-induced surface modification and the tubule-occluding properties of the remineralizing agent.

Device: Er,Cr;YSGG Laser, Waterlase, Biolase Technology Inc., Irvine, CA, ABD; Device: Remin Pro (VOCO, Cuxhaven, Germany)

Interventions

Er,Cr;YSGG Laser, Waterlase, Biolase Technology Inc., Irvine, CA, ABD DEVICE

Er,Cr;YSGG Laser

Combined Therapy: Er,Cr:YSGG Laser + Remin Pro; Er,Cr;YSGG Laser

Remin Pro (VOCO, Cuxhaven, Germany) DEVICE

a hydroxyapatite-containing remineralizing agent

Combined Therapy: Er,Cr:YSGG Laser + Remin Pro; Remin Pro, a hydroxyapatite-containing remineralizing agent

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

Sponsors & Collaborators

• Hacettepe University: lead

Study Sites (1)

Hacettepe University

Ankara, 06100, Turkey (Türkiye)

Location

Related Publications (2)

• AlHabdan A, AlAhmari F. Phototherapy Using Er,Cr:YSGG Laser as a Definitive Treatment for Dentin Hypersensitivity: A Systematic Review. Int J Gen Med. 2022 May 11;15:4871-4880. doi: 10.2147/IJGM.S355890. eCollection 2022.

  PMID: 35592535 BACKGROUND

• Shukla K, Saxena A, Joshi J, Jain D. A Comparative Study of the Effect of Tooth Mousse Plus Remin Pro and Fluor Protector Gel on Enamel Erosion: An In Vitro Study. Int J Clin Pediatr Dent. 2023 Aug;16(Suppl 1):S57-S62. doi: 10.5005/jp-journals-10005-2602.

  PMID: 37663219 BACKGROUND

MeSH Terms

Conditions

Dentin Sensitivity

Condition Hierarchy (Ancestors)

Tooth Diseases; Stomatognathic Diseases

Study Officials

• Ayşe Rüya Yazıcı, Prof.

  Hacettepe University

  PRINCIPAL INVESTIGATOR

• Ezgi Yeşim Aybek Fırat

  Hacettepe University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal İnvestigator, Research Assistant

Study Record Dates

• First Submitted: February 19, 2026
• First Posted: February 25, 2026
• Study Start: November 11, 2025
• Primary Completion: November 18, 2025
• Study Completion (Estimated): December 11, 2026
• Last Updated: February 25, 2026

Record last verified: 2026-02

Locations

TU (1)