VENtilation Modalities During Transport of PostoperatIve CRITically Ill Patients to the ICU

NCT07646249 | Not Yet Recruiting

• 1 other identifier: SIAARTI.2025.05 - VENTICRIT
• Study Type: observational
• Target: 800
• Locations: 0 countries
• Sites: N/A

Brief Summary

Patients undergoing major non-cardiac surgery may require postoperative mechanical ventilation and transfer from the operating room to the intensive care unit (ICU). This intra-hospital transport phase is critical, as patients may experience changes in respiratory and hemodynamic status, including alterations in oxygenation, ventilation, blood pressure, and heart rate. During transport, ventilatory support may be provided using different strategies, including manual ventilation with a bag-valve device or mechanical ventilation with a portable ventilator. Although both approaches are commonly used in clinical practice, there is limited evidence comparing their effects on respiratory function, gas exchange, and overall physiological stability during and after transport. This multicenter, prospective observational study aims to describe current clinical practices in ventilatory support during intra-hospital transport in adult patients undergoing non-cardiac surgery who require ICU admission. The study will also evaluate changes in vital signs, arterial blood gas parameters, and respiratory mechanics, as well as the occurrence of adverse events during transport and postoperative pulmonary complications within the first five days after surgery. No additional interventions or procedures beyond standard clinical care will be performed. All data will be collected as part of routine clinical practice. The results of this study are expected to improve the understanding of ventilation management during transport and to identify safer and more effective strategies for critically ill postoperative patients.

Conditions

Respiration, Artificial; Positive-Pressure Respiration; Postoperative Complications (Cardiopulmonary); Postoperative Complications; Critical Illness; Intensive Care Units

Keywords

Intra-hospital Transport; Mechanical Ventilation; Manual Ventilation; Respiration, Artificial; Positive-Pressure Respiration; Postoperative Care; Postoperative Complications; Postoperative Pulmonary Complications; Critical Illness; Intensive Care Units; Endotracheal Intubation; General Anesthesia; Non-Cardiac Surgery

Outcome Measures

Primary Outcomes (1)

• Ventilation strategies applied during transport

  Describe the ventilation strategies applied during transport from the operating room to ICU of the intubated patients subjected to general anesthesia for non-cardiac surgery requiring continuation of IMV in the postoperative period.

  Periprocedural period

Secondary Outcomes (25)

• assess changes in vital signs and blood gas analysis in the peri-transport period

  30 minutes before- 30 minutes after

• assess changes in vital signs and blood gas analysis in the peri-transport period

  30 minutes before- 30 minutes after

• assess changes in vital signs and blood gas analysis in the peri-transport period

  30 minutes before- 30 minutes after

• assess changes in vital signs and blood gas analysis in the peri-transport period

  30 minutes before- 30 minutes after

• assess changes in vital signs and blood gas analysis in the peri-transport period

  30 minutes before - 30 minutes after

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Intubated adult patients (≥18 years) undergoing general anesthesia (intravenous or mixed) for non-cardiac surgery, requiring transport from the operating room to the ICU for continuation/weaning from IMV in the postoperative period.

You may qualify if:

• Intubated patients undergoing general anesthesia for non-cardiac surgery
• Requirement for postoperative IMV
• Age ≥18 years

You may not qualify if:

• Patients undergoing cardiac surgery
• Patients receiving preoperative mechanical ventilation prior to surgery.

Sponsors & Collaborators

• Societa Italiana Anestesia Analgesia Rianimazione e Terapia Intensiva: lead
• Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria: collaborator

Related Publications (1)

• Morita Y. et al. Comparison of Manual and Mechanical Ventilation During Intensive Care Unit Transport Following Cardiac Surgery: Impact on Oxygenation, Ventilation, and Hemodynamic Stability. J Cardiothorac Vasc Anesth. 2025 Mar;39(3):644-652.LAS VEGAS investigators, Epidemiology, practice of ventilation and outcome for patients at increased risk of postoperative pulmonary complications: LAS VEGAS - an observational study in 29 countries. Eur J Anaesthesiol. 2017 Aug;34(8):492-507 Matthay et al. A New Global Definition of Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2024 Jan 1;209(1):37-47

  BACKGROUND

MeSH Terms

Conditions

Respiratory Aspiration; Postoperative Complications; Critical Illness

Condition Hierarchy (Ancestors)

Respiration Disorders; Respiratory Tract Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Disease Attributes

Central Study Contacts

RICERCA SIAARTI Ufficio Ricerca Clinica, Clinical Trial Office

CONTACT

0039 06 4452816; ricerca@siaarti.it

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 4, 2026
• First Posted: June 12, 2026
• Study Start (Estimated): July 1, 2026
• Primary Completion (Estimated): October 1, 2027
• Study Completion (Estimated): October 1, 2027
• Last Updated: June 12, 2026

Record last verified: 2026-06