Safety of Opportunistic Salpingectomy During Elective Laparoscopic Cholecystectomy.

NCT07642791 | Active Not Recruiting

• 1 other identifier: 2026-00157
• Study Type: interventional
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

The knowledge, coupled with epidemiological studies demonstrating lower ovarian cancer rates in women with a history of tubal sterilization has led to recommendations for opportunistic salpingectomy at the time of benign gynecological surgery. However, this recommendation was not explored in the setting of non-gynecological surgeries, of most if the surgery performed not in pelvis. This study aims to evaluate the safety of performing opportunistic salpingectomy at the time of elective laparoscopic cholecystectomy in women aged 45 years or older. Of note, the only available prospective study from Austria evaluated feasibility of combined operation. By assessing complication rates and other perioperative outcomes, the study seeks to determine if this combined approach is a safe for opportunistic ovarian cancer prevention. Ultimately, this research may inform surgical practice and potentially reduce the incidence of ovarian cancer in this population.

Conditions

Ovarian Cancer; Cholecystolithiasis

Outcome Measures

Primary Outcomes (1)

• Postoperative complications assesed with Comprehensive complication index.

  This will be the primary outcome measure, encompassing any complications assessed with Comprehensive Complication Index. The range between 0 and 100. The higher score means more complications.

  within 6 weeks after surgery

Secondary Outcomes (2)

• Operating time

  Operating time in minutes during surgical procedure

• Length of hospital stay

  Length of hospital stay: The number of days patients remain hospitalized after surgery untill discharge assedd at discharge (assessed at around 5 days).

Study Arms (2)

Experimental group

EXPERIMENTAL

Opportunistic salpingectomy during surgery.

Procedure: Opportunistic salpingectomy; Procedure: Cholecystectomy

Control group

ACTIVE COMPARATOR

Elective cholecystectomy

Procedure: Cholecystectomy

Interventions

Cholecystectomy PROCEDURE

Cholezystectomy as controll group

Control group; Experimental group

Opportunistic salpingectomy PROCEDURE

Opportunistic salpingectomy at the time of elective laparoscopic cholecystectomy will be performed in study group, while the control group undergo cholecystectomy without salpingectomy.

Experimental group

Eligibility Criteria

• Age: 45 Years+
• Gender Eligibility Details: . "sex and gender" dimensions are not relevant in this study including only female gender.
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Women aged 45 years or older.
• No known history of ovarian or fallopian tube cancer.
• Completed family planning.
• Scheduled to undergo elective laparoscopic cholecystectomy for benign gallbladder disease.
• Able to provide informed consent.
• Willing to comply with study procedures and follow-up assessments.

You may not qualify if:

• Previous abdominal Surgery or any inflammatory bowel disease.
• Current pregnancy or breastfeeding (verbally asked).
• Contraindications to laparoscopic surgery (e.g., severe cardiopulmonary disease, extensive prior abdominal surgery).
• Any medical condition that, in the opinion of the investigator, would preclude safe participation in the study or interfere with follow-up.
• Participation in another clinical trial that may confound the results of this study.

Sponsors & Collaborators

• University of Zurich: lead

Study Sites (1)

Division of Visceral Surgery and Transplantation , University Hospital Zurich

Zurich, 8091, Switzerland

Location

MeSH Terms

Conditions

Ovarian Neoplasms; Cholecystolithiasis

Interventions

Cholecystectomy

Condition Hierarchy (Ancestors)

Endocrine Gland Neoplasms; Neoplasms by Site; Neoplasms; Ovarian Diseases; Adnexal Diseases; Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Neoplasms, Female; Urogenital Neoplasms; Genital Diseases; Endocrine System Diseases; Gonadal Disorders; Cholelithiasis; Biliary Tract Diseases; Digestive System Diseases; Gallbladder Diseases

Intervention Hierarchy (Ancestors)

Biliary Tract Surgical Procedures; Digestive System Surgical Procedures; Surgical Procedures, Operative

Study Officials

• Dilmurodjon MDE Eshmuminov, MD

  Univercity hospital zurich

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Randomized Controlled Trial

Study Record Dates

• First Submitted: April 17, 2026
• First Posted: June 11, 2026
• Study Start: April 15, 2026
• Primary Completion (Estimated): May 31, 2028
• Study Completion (Estimated): May 31, 2029
• Last Updated: June 11, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

CH (1)