A Study of Apatinib Combined With Letrozole With or Without Fluzoparib in Estrogen Receptor-Positive, Platinum-Sensitive Recurrent Ovarian Cancer Previously Treated With First-Line PARP Inhibitor

NCT07000344 | Terminated

• 1 other identifier: K7506
• Study Type: interventional
• Target: 5
• Locations: 1 country
• Sites: 1

Brief Summary

This multicenter, open-label, prospective cohort clinical study enrolled 70 patients with late-stage ER（+）platinum-sensitive recurrent ovarian cancer who had achieved CR/PR after first-line PARP inhibitor maintenance therapy. The study was divided into two cohorts, with 35 participants in each. Cohort 1 (triple-drug group) received the following treatments: Apatinib: 250 mg orally once daily, with a 28-day treatment cycle. Fluzoparib: 100 mg orally twice daily, with a 4-week continuous treatment cycle. Letrozole: 2.5 mg orally once daily, with a 4-week continuous treatment cycle. Cohort 2 (dual-drug group) received: Apatinib: 250 mg orally once daily, with a 28-day treatment cycle. Letrozole: 2.5 mg orally once daily, with a 4-week continuous treatment cycle. reatment continued until disease progression, intolerable toxicity, or other protocol-specified reasons occurred.

Conditions

Ovarian Cancer

Keywords

ovarian cancer; Platinum-Sensitive Recurrent; Maintenance Therapy

Outcome Measures

Primary Outcomes (1)

• 6-month progression-free survival rate

  The proportion of patients who survive without disease progression (defined as any increase in tumor size or death from any cause) within 6 months from the start of the formal treatment.

  6 months

Secondary Outcomes (3)

• Progression-Free Survival (PFS)

  12 months

• Overall Survival (OS)

  24 moths

• Time to First Subsequent Anti-Cancer Treatment (TFST)

  12 months

Study Arms (2)

Cohort 1 (triple-drug group)

EXPERIMENTAL

Patients with advanced, estrogen receptor-positive, platinum-sensitive recurrent ovarian cancer who had previously received first-line poly (ADP-ribose) polymerase (PARP) inhibitor maintenance therapy.

Drug: Cohort 1 (triple-drug group)

Cohort 2 (dual-drug group)

EXPERIMENTAL

Patients with advanced, estrogen receptor-positive, platinum-sensitive recurrent ovarian cancer who had previously received first-line poly (ADP-ribose) polymerase (PARP) inhibitor maintenance therapy.

Drug: Cohort 2 (dual-drug group)

Interventions

Cohort 1 (triple-drug group) DRUG

Apatinib: 250 mg orally once daily, with a 28-day treatment cycle. Fluzoparib: 100 mg orally twice daily, with a 4-week continuous treatment cycle. Letrozole: 2.5 mg orally once daily, with a 4-week continuous treatment cycle. Treatment continued until disease progression, intolerable toxicity, or other protocol-specified reasons occurred.

Cohort 1 (triple-drug group)

Cohort 2 (dual-drug group) DRUG

Apatinib: 250 mg orally once daily, with a 28-day treatment cycle. Letrozole: 2.5 mg orally once daily, with a 4-week continuous treatment cycle. Treatment continued until disease progression, intolerable toxicity, or other protocol-specified reasons occurred.

Cohort 2 (dual-drug group)

Eligibility Criteria

• Age: 18 Years+
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age ≥ 18 years;
• ECOG Performance Status score of 0 or 1;
• Epithelial ovarian cancer with platinum-sensitive recurrence (no restriction on histological type);
• Patients who have received first-line maintenance treatment with olaparib or niraparib (including but not limited to) and achieved complete response (CR) or partial response (PR) to second-line platinum-based chemotherapy;
• Availability of genetic testing results (BRCA1/2) and estrogen receptor (ER) testing results (ER positivity is defined as ≥ 1% of tumor cells staining positive for ER);
• Estimated survival of ≥ 6 months;
• Good function of major organs in the subject, with relevant test results meeting the following requirements within 7 days prior to enrollment:
• Hematological tests (no blood transfusion or use of hematopoietic growth factors within 7 days prior to screening):
• Hemoglobin (Hb) ≥ 90 g/L; Absolute neutrophil count (ANC) ≥ 1.5×10⁹/L; Platelet count (PLT) ≥ 100×10⁹/L; White blood cell count (WBC) ≥ 3.0×10⁹/L and ≤ 15×10⁹/L;
• Biochemical tests (no blood transfusion or albumin within 7 days prior to screening):
• Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 times the upper limit of normal (ULN); Alkaline phosphatase (ALP) ≤ 2.5 ULN; Total bilirubin (TBIL) ≤ 1.5 ULN; Serum creatinine (Cr) ≤ 1.5 ULN, with creatinine clearance (CrCL) ≥ 60 mL/min (Cockcroft-Gault formula); Prothrombin time (PT) and activated partial thromboplastin time (APTT) ≤ 1.5 ULN, with international normalized ratio (INR) ≤ 1.5 ULN (not receiving anticoagulant therapy); Urinalysis: Urine protein \< 2+; if urine protein ≥ 2+, then 24-hour urine protein quantification must show protein ≤ 1 g; 12-lead electrocardiogram: Fridericia-corrected QT interval (QTcF) for females \< 470 ms;
• The subject voluntarily agrees to participate in this study, signs the informed consent form, and is willing to comply with the follow-up requirements.

You may not qualify if:

• Patients allergic to the trial drug or its excipients;
• Patients with active brain metastases;
• Patients who have received systemic treatment with traditional Chinese medicine or immunomodulatory agents (including thymosin, interferon, interleukin, excluding local use for pleural effusion control) within 2 weeks prior to the first dose;
• Patients with severe cardiovascular diseases: myocardial ischemia or myocardial infarction of grade II or above, uncontrolled arrhythmias (including QTc interval ≥ 470 ms); heart function of grade III-IV (according to the New York Heart Association \[NYHA\] classification), or echocardiogram showing left ventricular ejection fraction (LVEF) \< 50%;
• Patients with severe infections within 4 weeks prior to the first dose (e.g., requiring intravenous antibiotics, antifungals, or antivirals), or unexplained fever \> 38.5℃ during the screening period or prior to the first dose; or patients who have undergone major surgical procedures within 3 weeks prior to the first dose;
• Patients with type I diabetes mellitus whose blood glucose is controlled with insulin therapy may be eligible for this study;
• Patients undergoing systemic treatment with bronchodilators and having unsatisfactory asthma control are not eligible (patients with childhood asthma that has completely resolved and requires no intervention in adulthood may be included);
• Patients with human immunodeficiency virus (HIV) infection or known acquired immunodeficiency syndrome (AIDS), untreated active hepatitis B, hepatitis C (positive hepatitis C antibody and HCV-RNA above the lower limit of detection of the assay), or co-infection with hepatitis B and C;
• Patients who have undergone or are planned to undergo solid organ or hematopoietic stem cell transplantation during the study period (excluding corneal transplantation);
• Patients currently participating in an interventional clinical study or who have received other investigational drugs or study devices within 4 weeks prior to the first dose; patients who have not fully recovered from toxicities and/or complications caused by any prior interventions (i.e., ≤ grade 1 or returned to baseline, excluding fatigue or alopecia);
• Uncontrolled hypertension (systolic blood pressure ≥ 160 mmHg or diastolic blood pressure ≥ 110 mmHg despite optimal medical therapy);
• Coagulation abnormalities (INR \> 1.5 or prothrombin time (PT) \> ULN + 4 seconds or APTT \> 1.5 ULN), tendency to bleed, or receiving thrombolytic or anticoagulant therapy;
• Urinalysis showing proteinuria ≥ ++, or confirmed 24-hour urine protein ≥ 1.0 g;
• Patients with a history of allergy that may potentially cause hypersensitivity or intolerance to the trial drug or similar biologics;
• Patients with a history of substance abuse or psychiatric disorders that cannot be discontinued;

Sponsors & Collaborators

• Peking Union Medical College Hospital: lead

Study Sites (1)

Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences

Beijing, Beijing Municipality, 100021, China

Location

MeSH Terms

Conditions

Ovarian Neoplasms

Condition Hierarchy (Ancestors)

Endocrine Gland Neoplasms; Neoplasms by Site; Neoplasms; Ovarian Diseases; Adnexal Diseases; Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Neoplasms, Female; Urogenital Neoplasms; Genital Diseases; Endocrine System Diseases; Gonadal Disorders

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Chief Physician

Study Record Dates

• First Submitted: May 30, 2025
• First Posted: June 2, 2025
• Study Start: July 1, 2025
• Primary Completion: March 29, 2026
• Study Completion: March 30, 2026
• Last Updated: April 9, 2026

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)