The Effect of Respiratory Muscle Training on Cognitive Performance
1 other identifier
interventional
32
1 country
1
Brief Summary
Determine if exercise training for the respiratory muscles improves cognitive performance during periods when breathing against a resistance.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Mar 2026
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 27, 2026
CompletedFirst Submitted
Initial submission to the registry
June 1, 2026
CompletedFirst Posted
Study publicly available on registry
June 9, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
April 1, 2027
June 9, 2026
June 1, 2026
1 year
June 1, 2026
June 4, 2026
Conditions
Outcome Measures
Primary Outcomes (2)
Diaphragm thickness
ultrasound measurements of diaphragm thickness
Baseline and after 8 weeks of training
Cognitive performance
CAAPES performance with the higher percentage correct corresponding to a better performance.
Baseline and after 8 weeks of training
Secondary Outcomes (1)
Dyspnea
Baseline and after 8 weeks of training
Study Arms (2)
Active IMT
EXPERIMENTALInspiratory muscle training
Sham IMT
SHAM COMPARATORSham inspiratory muscle training
Interventions
8 weeks of active or sham inspiratory muscle training
Eligibility Criteria
You may qualify if:
- years old
- Body mass index \<30 kg/m2
- Naïve to IMT
- \>75% of predicted forced expiratory volume in 1 second (FEV1) / forced vital capacity (FVC) (FEV1/FVC)
- Access to smart phone or tablet with internet
You may not qualify if:
- Diagnosed:
- Cardiovascular disease
- Respiratory disease (including asthma)
- Metabolic disease
- Currently pregnant
- Unable to adhere to the IMT protocol
- Answering 'yes' to any of the questions on page one of the PAR-Q+
- Abnormal cognition assessed via the Montreal Cognitive Assessment (score of 25 or less)
- Self-reported color blindness
- Significant acute or chronic medical, neurologic, or illness in the participant that, in the judgment of the Principal Investigator, could compromise subject safety, limit the ability of the participant to complete the study, and/or compromise the objectives of the study
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Indiana Universitylead
- United States Air Force Research Laboratorycollaborator
Study Sites (1)
Indiana University
Bloomington, Indiana, 47405, United States
Study Officials
- PRINCIPAL INVESTIGATOR
Blair Johnson, PhD
Indiana University
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor Kinesiology
Study Record Dates
First Submitted
June 1, 2026
First Posted
June 9, 2026
Study Start
March 27, 2026
Primary Completion (Estimated)
April 1, 2027
Study Completion (Estimated)
April 1, 2027
Last Updated
June 9, 2026
Record last verified: 2026-06
Data Sharing
- IPD Sharing
- Will not share