Sellar Masses: Clinical and Imaging Features With Correlation to Histopathology and Surgical Approach

NCT07633860 | Completed DMC

• 1 other identifier: TMGH-2026-Ethics-30
• Study Type: observational
• Target: 49
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to learn about the clinical spectrum of sellar masses, aiming to understand the correlation between the imaging features and the future surgical approach and histopathology results. The main question it aims to answer is: Does being both LMIC and conflict country change the global data!? Participants were included during a period of 3 years in a governmental hospital TMGH.

Conditions

Sellar Mass; Pituitray Tumor

Keywords

Histopathology; Sellar Mass; Clinical spectrum

Outcome Measures

Primary Outcomes (1)

• Correlation between pre-operative radiological features and definitive histopathological diagnosis.

  To evaluate the diagnostic accuracy of pre-operative magnetic resonance imaging (MRI) by determining the percentage of cases where pre-operative radiological features match the definitive post-operative histopathological classification (e.g., pituitary adenoma, craniopharyngioma, meningioma).

  3 years

Study Arms (1)

Patients with confirmed sellar masses

Patients withe age of 11 to 65, who was diagnosed with sellar mass using MRI, and get treated surgically

Procedure: Craniectomy

Interventions

Craniectomy PROCEDURE

Bicoronal vs. Pterional approach vs endoscopic

Patients with confirmed sellar masses

Eligibility Criteria

• Age: 11 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

included all Patients presenting with sellar region masses from December 2022 to December 2025, at Neurosurgical department at TMGH

You may qualify if:

• Radiologically confirmed sellar, suprasellar, or parasellar mass.
• Surgical candidacy
• Histopathological confirmation
• Age ≥ 11 year

You may not qualify if:

• Incomplete diagnostics
• Recurrent disease
• Primary metastatic disease.

Sponsors & Collaborators

• Arab Board of Neurosurgery: lead

Study Sites (1)

Thawrh General Modern Hospital

Sanaa, 975, Yemen

Location

MeSH Terms

Interventions

Craniotomy

Intervention Hierarchy (Ancestors)

Neurosurgical Procedures; Surgical Procedures, Operative

Study Officials

• Adnan Al- Awdi, Neurosurgical consultant

  Arabic Board of Neurosurgery MD

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 21 Days
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Neurosurgical resident

Study Record Dates

• First Submitted: May 28, 2026
• First Posted: June 8, 2026
• Study Start: December 1, 2022
• Primary Completion: December 1, 2025
• Study Completion: December 1, 2025
• Last Updated: June 10, 2026

Record last verified: 2026-06

Locations

YE (1)