NCT04745715

Brief Summary

The investigators collected the data from the investigators' center between January 2011 and October 2020. The study included all non-small cell lung cancer patients with surgically excised brain metastasis. The investigators analysis the correlation of gene mutation and the disease course.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
110

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Jan 2011

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2011

Completed
9.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 31, 2020

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

February 3, 2021

Completed
6 days until next milestone

First Posted

Study publicly available on registry

February 9, 2021

Completed
1.7 years until next milestone

Study Completion

Last participant's last visit for all outcomes

October 31, 2022

Completed
Last Updated

April 4, 2023

Status Verified

December 1, 2020

Enrollment Period

9.8 years

First QC Date

February 3, 2021

Last Update Submit

April 3, 2023

Conditions

NSCLC Stage IVBrain Metastases

Outcome Measures

Primary Outcomes (1)

  • postoperative survival

    From date of craniectomy until the date of patient deceased or date of last followed medical record, with median follow up around to 20 months

Interventions

craniectomyPROCEDURE

craniectomy outcomes and survival

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

patients with non-small cell lung cancer underwent craniectomy, who completed postoperative whole brain radiotherapy and associated chemo or target therapy

You may qualify if:

  • \- patients diagnosed with non-small cell lung cancer who underwent craniectomy and subsequent whole brain radiotherapy and associated chemo or target therapy

You may not qualify if:

  • patient who did not receive postoperative adjuvant therapy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

National Cheng Kung University hospital

Tainan, Taiwan

Location

MeSH Terms

Conditions

Carcinoma, Non-Small-Cell LungBrain Neoplasms

Interventions

Craniotomy

Condition Hierarchy (Ancestors)

Carcinoma, BronchogenicBronchial NeoplasmsLung NeoplasmsRespiratory Tract NeoplasmsThoracic NeoplasmsNeoplasms by SiteNeoplasmsLung DiseasesRespiratory Tract DiseasesCentral Nervous System NeoplasmsNervous System NeoplasmsBrain DiseasesCentral Nervous System DiseasesNervous System Diseases

Intervention Hierarchy (Ancestors)

Neurosurgical ProceduresSurgical Procedures, Operative

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 3, 2021

First Posted

February 9, 2021

Study Start

January 1, 2011

Primary Completion

October 31, 2020

Study Completion

October 31, 2022

Last Updated

April 4, 2023

Record last verified: 2020-12

Data Sharing

IPD Sharing
Will not share

Locations

TW(1)