Dentine Hypersensitivity Using Dentine Adhesive With Strontium-doped Bioactive Glass-Ceramic

NCT07628712 | Recruiting

• 1 other identifier: UW25-491
• Study Type: interventional
• Target: 142
• Locations: 1 country
• Sites: 2

Brief Summary

The goal of this clinical trial is to determine whether strontium-doped bioactive glass-ceramic (SBGC)-filled dentine adhesive is effective in relieving dentine hypersensitivity. The main question it aims to answer is: Is SBGC-filled dentine adhesive more effective in reducing dentine hypersensitivity than non-SBGC-filled dentine adhesive? Researchers will compare SBGC-filled dentine adhesive to a dentine adhesive to see if SBGC-filled dentine adhesive is more effective at relieving dentine hypersensitivity. Participants will receive a single application of either SBGC-filled dentine adhesive (intervention group) or dentine adhesive (control group) on the root surfaces of teeth presenting with pain subject to an air-blast test. The degree of pain will be assessed using a Sensitivity Score at baseline, immediately after application of either the intervention dentine adhesive or control dentine adhesive. The participants will visit the clinic at 1 month, 3 months and 6 months for re-assessment of the severity of dentine hypersensitivity.

Conditions

Dentine Hypersensitivity

Keywords

dentine hypersensitivity; bioactive glass; resin bonding system

Outcome Measures

Primary Outcomes (1)

• Severity of dentine hypersensitivity measured by a sensitivity score

  The tooth/teeth with dentine hypersensitivity will be identified. A 3-in-1 air syringe will be used to provide a continuous air blast for 5 seconds. The participants will rate the degree of pain of all the teeth under assessment using a Sensitivity Score (SS) which is a visual analog scale modified with the addition of adjective words and facial expression diagrams according to the verbal descriptor scale. The SS ranges from 0 to 10, where 0 indicates no discomfort and 10 indicates maximal pain causing significant distress.

  Baseline, immediately, 1 month, 3 months and 6 months after intervention

Study Arms (2)

Control

ACTIVE COMPARATOR

A single application of a universal dentine adhesive

Other: Universal dentine adhesive

Intervention

EXPERIMENTAL

A single application of strontium-doped bioactive glass ceramic-filled dentine adhesive

Drug: Strontium-doped bioactive glass-ceramic-filled dentine adhesive

Interventions

Strontium-doped bioactive glass-ceramic-filled dentine adhesive DRUG

Strontium-doped bioactive glass-ceramic-filled dentine adhesive Strontium-dope bioactive glass-ceramic: Dencare (Chongqing) Oral Care Company Limited Dentine adhesive: ScotchbondTM Universal Adhesive, 3M ESPE, Deutschland GmbH, Neuss, Germany

Intervention

Universal dentine adhesive OTHER

universal dentine adhesive (ScotchbondTM Universal Adhesive, Neuss, Germany)

Control

Eligibility Criteria

• Age: 18 Years - 69 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• individuals who experienced cervical dentine sensitivity for 1 month or more

You may not qualify if:

• \) \<20 teeth; 2) teeth with poor oral hygiene, severe periodontal conditions, with caries, faulty restorations, dentine exposure at the occlusal surface, covered by prosthetics or orthodontic appliances, or undergoing endodontic treatment; 3) currently using or have used any desensitizing agents in the past 3 months; or have undergone restorative treatment on the sensitive tooth; 4) with a severe medical condition or in chronic use of a medication that could have interfered with the perception of pain or any condition/medication that causes xerostomia

Sponsors & Collaborators

• The University of Hong Kong: lead

Study Sites (2)

Clinical Research Center, the Prince Philips Dental Hospital

Hong Kong, Hong Kong

RECRUITING

the University of Hong Kong

Hong Kong, Hong Kong

RECRUITING

MeSH Terms

Conditions

Dentin Sensitivity

Condition Hierarchy (Ancestors)

Tooth Diseases; Stomatognathic Diseases

Study Officials

• Katherine CM LEUNG, BDS MDS PhD

  The University of Hong Kong

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Katherine CM LEUNG, BDS MDS PhD

CONTACT

852-28590307; kcmleung@hku.hk

Minnie Y He, BDS MDS PhD

CONTACT

852-28590307; u3012606@connect.hku.hk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 24, 2026
• First Posted: June 5, 2026
• Study Start: June 16, 2026
• Primary Completion (Estimated): May 30, 2027
• Study Completion (Estimated): September 30, 2027
• Last Updated: September 21, 2026

Record last verified: 2026-03

Locations

HK (2)