Dentine Hypersensitivity Using Dentine Adhesive With Strontium-doped Bioactive Glass-Ceramic

NCT07628712 | Not Yet Recruiting

• 1 other identifier: UW25-491
• Study Type: interventional
• Target: 142
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of this clinical trial is to determine whether strontium-doped bioactive glass-ceramic (SBGC)-filled dentine adhesive is effective in relieving dentine hypersensitivity. The main question it aims to answer is: Is SBGC-filled dentine adhesive more effective in reducing dentine hypersensitivity than non-SBGC-filled dentine adhesive? Researchers will compare SBGC-filled dentine adhesive to a dentine adhesive to see if SBGC-filled dentine adhesive is more effective at relieving dentine hypersensitivity. Participants will receive a single application of either SBGC-filled dentine adhesive (intervention group) or dentine adhesive (control group) on the root surfaces of teeth presenting with pain subject to an air-blast test. The degree of pain will be assessed using a Sensitivity Score at baseline, immediately after application of either the intervention dentine adhesive or control dentine adhesive. The participants will visit the clinic at 1 month, 3 months and 6 months for re-assessment of the severity of dentine hypersensitivity.

Conditions

Dentine Hypersensitivity

Keywords

dentine hypersensitivity; bioactive glass; resin bonding system

Outcome Measures

Primary Outcomes (1)

• Severity of dentine hypersensitivity measured by a sensitivity score

  The tooth/teeth with dentine hypersensitivity will be identified. A 3-in-1 air syringe will be used to provide a continuous air blast for 5 seconds. The participants will rate the degree of pain of all the teeth under assessment using a Sensitivity Score (SS) which is a visual analog scale modified with the addition of adjective words and facial expression diagrams according to the verbal descriptor scale. The SS ranges from 0 to 10, where 0 indicates no discomfort and 10 indicates maximal pain causing significant distress.

  Baseline, immediately, 1 month, 3 months and 6 months after intervention

Study Arms (2)

Control

ACTIVE COMPARATOR

A single application of a universal dentine adhesive

Other: Universal dentine adhesive

Intervention

EXPERIMENTAL

A single application of strontium-doped bioactive glass ceramic-filled dentine adhesive

Drug: Strontium-doped bioactive glass-ceramic-filled dentine adhesive

Interventions

Strontium-doped bioactive glass-ceramic-filled dentine adhesive DRUG

Strontium-doped bioactive glass-ceramic-filled dentine adhesive Strontium-dope bioactive glass-ceramic: Dencare (Chongqing) Oral Care Company Limited Dentine adhesive: ScotchbondTM Universal Adhesive, 3M ESPE, Deutschland GmbH, Neuss, Germany

Intervention

Universal dentine adhesive OTHER

universal dentine adhesive (ScotchbondTM Universal Adhesive, 3M ESPE, Deutschland GmbH, Neuss, Germany)

Control

Eligibility Criteria

• Age: 18 Years - 69 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• individuals who experienced cervical dentine sensitivity for 1 month or more

You may not qualify if:

• \) \<20 teeth; 2) teeth with poor oral hygiene, severe periodontal conditions, with caries, faulty restorations, dentine exposure at the occlusal surface, covered by prosthetics or orthodontic appliances, or undergoing endodontic treatment; 3) currently using or have used any desensitizing agents in the past 3 months; or have undergone restorative treatment on the sensitive tooth; 4) with a severe medical condition or in chronic use of a medication that could have interfered with the perception of pain or any condition/medication that causes xerostomia

Sponsors & Collaborators

• The University of Hong Kong: lead

MeSH Terms

Conditions

Dentin Sensitivity

Condition Hierarchy (Ancestors)

Tooth Diseases; Stomatognathic Diseases

Study Officials

• Katherine CM LEUNG, BDS MDS PhD

  The University of Hong Kong

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Katherine CM LEUNG, BDS MDS PhD

CONTACT

852-28590307; kcmleung@hku.hk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 24, 2026
• First Posted: June 5, 2026
• Study Start: May 18, 2026
• Primary Completion (Estimated): May 30, 2027
• Study Completion (Estimated): September 30, 2027
• Last Updated: June 5, 2026

Record last verified: 2026-03