Efficacy of Novel Titania Nanoparticles Enriched Mouth Wash in Treating Dentine Hypersensitivity

NCT06790953 | Completed

• 1 other identifier: SOD/ERB/2024/36-200
• Study Type: interventional
• Target: 130
• Locations: 1 country
• Sites: 1

Brief Summary

Randomized Clinical trial to compare the reduction in dentin hypersensitivity after incorporating biogenically fabricated titania nanoparticles enriched Mouth Wash and Conventional Mouth Wash.Participants ranging between 20-50 years were allocated in two groups. Group A will use Conventional Mouth Wash without Nanoparticles. Group B will use titania nanoparticles enriched Mouth Wash. Both will use them for three months and then their VAS scoring will be checked.

Conditions

Dentine Hypersensitivity

Keywords

Bacillus coagulans; Biogenic; Dentin Hypersensitivity; Nanoparticles; Titanium oxide (TiO2 Nps)

Outcome Measures

Primary Outcomes (1)

• Post mouth wash utilization Dentine Hypersensitivity

  Evaluation of dentine hypersensitivity with Conventional Mouth Wash without titania nanoparticles and Novel Nps Mouth Wash with titania nanoparticles on human tooth dentin. Visual analog scale with scoring from 0 to 100 where Score 100 means worst outcomes.

  3 months

Study Arms (2)

Group-A: Conventional Mouth wash .

EXPERIMENTAL

Group A will receive conventional mouthwash for treatment of dentin hypersensitivity

Procedure: Group- A Conventional Sensed Mouth Wash

Group-B: Novel Titania nanoparticles Mouth wash

EXPERIMENTAL

Group B will receive novel Titania nano particles reinforced mouthwash for treatment of dentin hypersensitivity

Procedure: Group-B Novel Titania nanoparticles enriched Mouth Wash

Interventions

Group- A Conventional Sensed Mouth Wash PROCEDURE

In Group- A Conventional Sensed Mouth Wash will be used for treatment of Dentin hypersensitivity. Visual Analogue scoring system will be used to calculate the dentin hypersensitivity.

Group-A: Conventional Mouth wash .

Group-B Novel Titania nanoparticles enriched Mouth Wash PROCEDURE

In Group-B Novel Titania nanoparticles enriched Mouth wash will be used to treat the Dentin hypersensitivity. Visual Analogue scoring system will be used to calculate the dentin hypersensitivity.

Group-B: Novel Titania nanoparticles Mouth wash

Eligibility Criteria

• Age: 20 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Participants ranging between 20-50 years, good general health but developed dentine sensitivity associated with tooth surface wear and loss during the past 6 months.
• There was no history of allergy.
• Participants did not use any mouth wash , dentifrice or medication in the last 3 months.
• The involved teeth were viable, non-shaky, devoid of any decay, cracks and fillings.
• There was an essential positive response to the provoking Air stimuli.
• These teeth should display the visible signs of tooth loss and wear such as : attrition, abrasion, erosion and abfraction.

You may not qualify if:

• Participants that might have developed allergy or used medications during the last 2 weeks or more.
• The teeth having cracks, decay and fillings were also excluded. Patients who have undergone any periodontal surgery or gross periodontal issues.
• Participants who used any desensitisizing toothpastes/mouthwashes and tooth bleaching agents within 2 months of the trial were also excluded positively.

Sponsors & Collaborators

• Pakistan Institute of Medical Sciences: lead

Study Sites (1)

School of Dentistry, Pakistan Institute of Medical Sciences

Islamabad, Punjab Province, 44080, Pakistan

Location

Related Publications (1)

• Aboelenein AZ, Riad MI, Haridy MF. Effect of a Self-Etch Adhesive Containing Nanobioglass on Postoperative Sensitivity of Posterior Composite Restorations - A Randomized Trial. Open Access Maced J Med Sci. 2019 Jul 25;7(14):2313-2320. doi: 10.3889/oamjms.2019.585. eCollection 2019 Jul 30.

  PMID: 31592280 BACKGROUND

MeSH Terms

Conditions

Dentin Sensitivity

Condition Hierarchy (Ancestors)

Tooth Diseases; Stomatognathic Diseases

Study Officials

• Afsheen Mansoor, PhD

  School of Dentistry, Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad.

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, OUTCOMES ASSESSOR
• Masking Details: This is a triple-blinded study in which the participant, care provider and outcome assessor will be masked
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: In this study, participants will be allocated in two groups by Consecutive random sampling technique

Study Record Dates

• First Submitted: January 18, 2025
• First Posted: January 24, 2025
• Study Start: June 13, 2024
• Primary Completion: December 3, 2024
• Study Completion: December 3, 2024
• Last Updated: February 4, 2025

Record last verified: 2025-01

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)