Single Application of Desensitizing Pastes as Dentin Sensitivity Treatment

NCT02018783 | Completed

• 1 other identifier: dessensibilizantes
• Study Type: interventional
• Target: 138
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study was to evaluate the efficacy of three desensitizing toothpastes for immediate and intermediate-term relief of CDH, when compared with a control toothpaste. One hundred and thirty-eight hypersensitive teeth were diagnosed and randomized into four groups according to the therapeutic agent of each desensitizing cream tested: 1) strontium acetate and calcium carbonate, 2) calcium carbonate and arginine 8%, 3) calcium phosphate nanoparticles and 4) a control toothpaste. The desensitizing creams were applied according to the manufacturer's instructions. Cervical dentin hypersensitivity was assessed at baseline, immediately, 24 hours and 30 days after the treatment. Cold and evaporative tests were used to assess the sensitivity level.

Conditions

Dentine Hypersensitivity

Outcome Measures

Primary Outcomes (1)

• cervical dentin hypersensitivity

  The cervical dentin hypersensitivity was evaluated by an air blast (evaporative stimulus) for 5 seconds, and by a tetrafluoroethane spray (cold stimulus) for 5 seconds.

  30 days

Study Arms (4)

Sensodyne

EXPERIMENTAL

Digital application for 60 seconds.

Procedure: Sensodyne

Colgate

EXPERIMENTAL

Slow-speed handpiece with a Robson brush for 3 seconds by repeating the procedure

Procedure: Colgate

Nano P

EXPERIMENTAL

Slow-speed handpiece with a Robson brush for 10 seconds

Procedure: Nano P

Cocorico

PLACEBO COMPARATOR

Digital application for 60 seconds

Procedure: Cocorico

Interventions

Colgate PROCEDURE

Slow-speed handpiece with a Robson brush for 3 seconds by repeating the procedure

Colgate

Sensodyne PROCEDURE

Digital application for 60 seconds.

Sensodyne

Nano P PROCEDURE

Slow-speed handpiece with a Robson brush for 10 seconds

Nano P

Cocorico PROCEDURE

Digital application for 60 seconds

Cocorico

Eligibility Criteria

• Age: 22 Years - 48 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• subjects 18 years or older
• in good general and oral health; have complaint of CDH in teeth distributed in all 4 quadrants
• not making use of desensitizing agents
• not having undergone periodontal treatment over the past 3 months
• respond to evaporative stimulus with a score ≥ 1.5 cm on VAS

You may not qualify if:

• patients who presented restorations and caries near the exposed dentin of the hypersensitive teeth
• who made frequent use of painkillers, anti-inflammatory and antidepressants drugs

Sponsors & Collaborators

• Federal University of São Paulo: lead

Study Sites (1)

Periodontics Clinic, Department of Dentistry

Diamantina, Minas Gerais, 39100000, Brazil

Location

MeSH Terms

Conditions

Dentin Sensitivity

Interventions

Sodium Fluoride; Sensodyne

Condition Hierarchy (Ancestors)

Tooth Diseases; Stomatognathic Diseases

Intervention Hierarchy (Ancestors)

Fluorides; Hydrofluoric Acid; Fluorine Compounds; Inorganic Chemicals; Sodium Compounds; Cariostatic Agents; Biomedical and Dental Materials; Manufactured Materials; Technology, Industry, and Agriculture

Study Officials

• Olga D Flecha, PhD

  Federal University of São Paulo

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD

Study Record Dates

• First Submitted: December 7, 2013
• First Posted: December 23, 2013
• Study Start: April 1, 2013
• Primary Completion: August 1, 2013
• Study Completion: August 1, 2013
• Last Updated: December 23, 2013

Record last verified: 2013-12

Locations

BR (1)