Computer Vision-Based Recognition of Parathyroid Glands and Recurrent Laryngeal Nerves in Endoscopic Surgery

NCT07628543 | Not Yet Recruiting

• 1 other identifier: PTAIR 3.0
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to evaluate the performance of the PTAIR computer vision model for recognizing parathyroid glands and recurrent laryngeal nerves during endoscopic thyroid surgery. Multicenter intraoperative endoscopic surgery videos will be prospectively collected. Using the video recorder timeline as the unified time reference, the first recognition time of parathyroid glands and recurrent laryngeal nerves by PTAIR, junior physicians, and senior physicians will be recorded during surgery. The continuous recognition time of parathyroid glands and recurrent laryngeal nerves by PTAIR will also be recorded. This study focuses on the recognition performance of PTAIR in real-world multicenter endoscopic thyroid surgery settings. At this stage, PTAIR will not be used to guide intraoperative surgical decision-making, and the study will not evaluate the effect of PTAIR on clinical outcomes. The collected video data will be used to assess the performance of PTAIR under different centers, surgeons, equipment conditions, and surgical field conditions, and may provide data support for future model optimization.

Conditions

Thyroid Diseases; Thyroid Neoplasms

Keywords

PTAIR; Computer Vision; Endoscopic Thyroid Surgery; Parathyroid Gland Recognition; Recurrent Laryngeal Nerve Recognition; Model Validation

Outcome Measures

Primary Outcomes (4)

• First Recognition Time of the Recurrent Laryngeal Nerve

  Using the video recorder timeline as the unified time reference, the first recognition time of the recurrent laryngeal nerve by PTAIR, junior physicians, and senior physicians will be recorded during surgery. All recognitions will be based on the same intraoperative endoscopic visual field.

  Intraoperative period

• First Recognition Time of the Parathyroid Gland

  Using the video recorder timeline as the unified time reference, the first recognition time of the parathyroid gland by PTAIR, junior physicians, and senior physicians will be recorded during surgery. All recognitions will be based on the same intraoperative endoscopic visual field.

  Intraoperative period

• Continuous Recognition Time of the Recurrent Laryngeal Nerve

  Using the video recorder timeline as the unified time reference, the continuous recognition time of the recurrent laryngeal nerve by PTAIR will be recorded during surgery.

  Intraoperative period

• Continuous Recognition Time of the Parathyroid Gland

  Using the video recorder timeline as the unified time reference, the continuous recognition time of the parathyroid gland by PTAIR will be recorded during surgery.

  Intraoperative period

Secondary Outcomes (6)

• AP50 for Recurrent Laryngeal Nerve Recognition

  From completion of intraoperative video collection to completion of expert annotation and model analysis

• AP50 for Parathyroid Gland Recognition

  From completion of intraoperative video collection to completion of expert annotation and model analysis

• Comparison of First Recognition Time of the Recurrent Laryngeal Nerve Between PTAIR and Physicians

  Intraoperative period

• Comparison of First Recognition Time of the Parathyroid Gland Between PTAIR and Physicians

  Intraoperative period

• In Situ Recognition Rate of the Parathyroid Gland

  From completion of intraoperative video collection to completion of expert review

Study Arms (1)

Multicenter Endoscopic Thyroid Surgery Video Cohort

This cohort includes adult patients with thyroid disease who are scheduled to undergo endoscopic thyroid surgery and consent to intraoperative video recording and research use. Recorder-based intraoperative videos will be collected to evaluate the recognition performance of PTAIR for parathyroid glands and recurrent laryngeal nerves. The recognition results of PTAIR will be compared with those of junior and senior physicians based on the same intraoperative endoscopic visual field and the same video recording timeline.

Other: PTAIR Computer Vision Model Assessment

Interventions

PTAIR Computer Vision Model Assessment OTHER

PTAIR is a computer vision model used to recognize parathyroid glands and recurrent laryngeal nerves in endoscopic thyroid surgery videos. In this observational study, PTAIR will be used to analyze recorder-based intraoperative videos and evaluate first recognition time, continuous recognition time, and recognition performance. PTAIR results will be compared with recognition by junior and senior physicians based on the same intraoperative endoscopic visual field and the same video recording timeline. At this stage, PTAIR will not be used to guide intraoperative surgical decision-making.

Multicenter Endoscopic Thyroid Surgery Video Cohort

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population includes adult patients with benign or malignant thyroid disease who are scheduled to undergo endoscopic thyroid surgery at participating centers. Eligible patients will be prospectively enrolled during the study period if they meet the inclusion and exclusion criteria, agree to intraoperative video recording and research use, and have standardized recorder-based endoscopic surgical videos available. The study will evaluate PTAIR recognition performance for parathyroid glands and recurrent laryngeal nerves and compare it with recognition by junior and senior physicians based on the same intraoperative endoscopic visual field and the same video recording timeline.

You may qualify if:

• Age 18 years or older.
• Patients with benign or malignant thyroid disease who are scheduled to undergo endoscopic thyroid surgery.
• Standardized recorder-based intraoperative video collection is planned during surgery.
• Patients agree to intraoperative video recording, de-identification, and research use.
• Basic perioperative clinical data are available.
• The participating center is able to follow the standardized procedures for video collection, data upload, data security, and annotation quality control.

You may not qualify if:

• Refusal to provide informed consent.
• Patients scheduled to undergo conventional open thyroid surgery.
• Standardized recorder-based intraoperative video collection cannot be performed.
• Intraoperative video quality is insufficient for model analysis or expert review.
• Key surgical phases are missing from the video recording.
• Expert annotation or review of the parathyroid glands or recurrent laryngeal nerves cannot be completed.
• Video de-identification fails.
• Severe missing perioperative clinical data.

Sponsors & Collaborators

• Peking University Shenzhen Hospital: collaborator
• Cancer Hospital of Guangxi Medical University: collaborator
• First Hospital of China Medical University: collaborator
• Peking Union Medical College Hospital: collaborator
• United Family Healthcare: collaborator
• Mahidol University: collaborator
• Rio de Janeiro State University: collaborator
• Fujian Medical University: lead
• First Affiliated Hospital of Guangxi Medical University: collaborator
• Longyan First Hospital, Affiliated to Fujian Medical University: collaborator
• The First Affiliated Hospital of Zhengzhou University: collaborator

Study Sites (1)

Fujian Medical University Union Hospital

Fuzhou, Fujian, 350001, China

Location

Related Publications (2)

• Wang B, Zheng J, Yu JF, Lin SY, Yan SY, Zhang LY, Wang SS, Cai SJ, Abdelhamid Ahmed AH, Lin LQ, Chen F, Randolph GW, Zhao WX. Development of Artificial Intelligence for Parathyroid Recognition During Endoscopic Thyroid Surgery. Laryngoscope. 2022 Dec;132(12):2516-2523. doi: 10.1002/lary.30173. Epub 2022 May 31.

  PMID: 35638245 BACKGROUND

• Wang B, Yu JF, Lin SY, Li YJ, Huang WY, Yan SY, Wang SS, Zhang LY, Cai SJ, Wu SB, Li MY, Wang TY, Abdelhamid Ahmed AH, Randolph GW, Chen F, Zhao WX. Intraoperative AI-assisted early prediction of parathyroid and ischemia alert in endoscopic thyroid surgery. Head Neck. 2024 Aug;46(8):1975-1987. doi: 10.1002/hed.27629. Epub 2024 Feb 13.

  PMID: 38348564 BACKGROUND

MeSH Terms

Conditions

Thyroid Diseases; Thyroid Neoplasms

Condition Hierarchy (Ancestors)

Endocrine System Diseases; Endocrine Gland Neoplasms; Neoplasms by Site; Neoplasms; Head and Neck Neoplasms

Study Officials

• Bo Wang MD, Principal Investigator

  Fujian Medical University Union Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Bo Wang Professor, MD

CONTACT

86+13959123550; wangbo@fjmu.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD

Study Record Dates

• First Submitted: June 1, 2026
• First Posted: June 5, 2026
• Study Start: June 1, 2026
• Primary Completion (Estimated): May 31, 2027
• Study Completion (Estimated): May 31, 2028
• Last Updated: June 5, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)