Thyroidectomy-specific Enhanced Recovery After Surgery (ERAS) Protocol

NCT07575243 | Completed

• 1 other identifier: M.I.Omar-ERAS26
• Study Type: observational
• Target: 143
• Locations: 1 country
• Sites: 1

Brief Summary

Thyroidectomy is generally considered a low-to-moderate risk operation; however, postoperative pain, nausea/vomiting, and prolonged hospital stays remain common issues. Enhanced Recovery After Surgery (ERAS) pathways aim to optimize perioperative care and accelerate recovery. This study evaluates the effectiveness and safety of a standardized ERAS pathway in patients undergoing elective thyroidectomy. The prospective ERAS cohort is compared with a historical control group receiving conventional care to assess the impact on the length of hospital stay, postoperative pain, opioid consumption, and complication rates.

Conditions

Thyroid Diseases; Goiter; Thyroid Neoplasms

Keywords

Enhanced recovery after surgery; ERAS; Multimodal perioperative care; Length of hospital stay; Thyroidectomy; Opioid-sparing multimodal analgesia

Outcome Measures

Primary Outcomes (1)

• Length of hospital stay

  Hours from surgery end to discharge

  Up to 30 days post-surgery

Secondary Outcomes (5)

• Postoperative pain scores

  Assessed in the first 24 hours postoperatively

• Total opioid consumption

  Within first 24 hours

• Postoperative nausea and vomiting (PONV)

  Up to 24 hours postoperatively

• Rate of postoperative hypocalcemia

  First 30 days from the surgery

• 30-day unplanned readmission rate

  Up to 30 days postoperative

Study Arms (2)

ERAS group

A prospective cohort undergoing elective thyroidectomy under an ERAS protocol.

Procedure: Enhanced Recovery After Surgery protocol

Control group

A historical control cohort undergoing thyroidectomy under conventional care during the 12 months preceding ERAS implementation

Procedure: Conventional perioperative care

Interventions

Enhanced Recovery After Surgery protocol PROCEDURE

This incorporates standardized preoperative counseling, reduced fasting, multimodal opioid-sparing analgesia, total intravenous anesthesia, selective drain use, early oral intake and mobilization, and PTH-guided calcium supplementation

Also known as: ERAS

ERAS group

Conventional perioperative care PROCEDURE

This often involves prolonged preoperative fasting, opioid-based analgesia, and delayed mobilization

Control group

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients scheduled for elective thyroidectomy for benign or malignant disease at a tertiary cancer institute

You may qualify if:

• Patients aged 18-75 years
• ASA physical status I-III.
• Scheduled for elective thyroidectomy for benign or malignant disease.

You may not qualify if:

• Re-operative thyroid surgery
• Concomitant neck dissection
• Inability to comply with the ERAS pathway

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Surgical Oncology Department, South Egypt Cancer Institute, Assiut University

Asyut, Asyut Governorate, 71516, Egypt

Location

Related Publications (5)

• Althans AR, Holder-Murray J, Tessler RA. The Future of Enhanced Recovery After Surgery-Precision vs Protocol. JAMA Netw Open. 2024 Jun 3;7(6):e2418968. doi: 10.1001/jamanetworkopen.2024.18968. No abstract available.

  PMID: 38888927 BACKGROUND

• Sauro KM, Smith C, Ibadin S, Thomas A, Ganshorn H, Bakunda L, Bajgain B, Bisch SP, Nelson G. Enhanced Recovery After Surgery Guidelines and Hospital Length of Stay, Readmission, Complications, and Mortality: A Meta-Analysis of Randomized Clinical Trials. JAMA Netw Open. 2024 Jun 3;7(6):e2417310. doi: 10.1001/jamanetworkopen.2024.17310.

  PMID: 38888922 BACKGROUND

• Simpson JC, Bao X, Agarwala A. Pain Management in Enhanced Recovery after Surgery (ERAS) Protocols. Clin Colon Rectal Surg. 2019 Mar;32(2):121-128. doi: 10.1055/s-0038-1676477. Epub 2019 Feb 28.

  PMID: 30833861 BACKGROUND

• Machado N, Mortlock R, Maduka R, Souza Cunha AE, Dyer E, Long A, Canner JK, Tanella A, Gibson C, Hyman J, Ogilvie J. Early observations with an ERAS pathway for thyroid and parathyroid surgery: Moving the goalposts forward. Surgery. 2024 Jan;175(1):114-120. doi: 10.1016/j.surg.2023.06.052. Epub 2023 Nov 15.

  PMID: 37973430 BACKGROUND

• Lee DJ, Chin CJ, Hong CJ, Perera S, Witterick IJ. Outpatient versus inpatient thyroidectomy: A systematic review and meta-analysis. Head Neck. 2018 Jan;40(1):192-202. doi: 10.1002/hed.24934. Epub 2017 Nov 9.

  PMID: 29120517 BACKGROUND

MeSH Terms

Conditions

Thyroid Diseases; Goiter; Thyroid Neoplasms

Condition Hierarchy (Ancestors)

Endocrine System Diseases; Endocrine Gland Neoplasms; Neoplasms by Site; Neoplasms; Head and Neck Neoplasms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, Surgical Oncology Department

Study Record Dates

• First Submitted: May 2, 2026
• First Posted: May 8, 2026
• Study Start: May 1, 2024
• Primary Completion: May 31, 2025
• Study Completion: May 31, 2025
• Last Updated: May 8, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)