CIMT Versus HABIT in Late Sub-Acute Post-Stroke Rehabilitation

NCT07626554 | Active Not Recruiting

• 1 other identifier: HAFSA LATIF
• Study Type: interventional
• Target: 34
• Locations: 1 country
• Sites: 1

Brief Summary

This study will compare the effects of Constraint Induced Movement Therapy and Hand-Arm Bimanual Intensive Training on upper extremity function in late sub-acute post-stroke patients. It will be a randomized controlled trial. Eligible participants will be randomly allocated into two groups. One group will receive Constraint Induced Movement Therapy, while the other group will receive Hand-Arm Bimanual Intensive Training. Both groups will also receive standard physiotherapy for mobility and postural control. The intervention will continue for 3 weeks. Outcomes will be assessed at baseline and after the intervention using upper limb function and motor control assessment tools.

Conditions

Stroke

Outcome Measures

Primary Outcomes (2)

• Fugl-Meyer Assessment - Upper Extremity (FMA-UE)

  Measures motor recovery and voluntary movement of the affected upper limb after stroke.

  Baseline and Week 3 (Post-intervention)

• Action Research Arm Test (ARAT)

  Assesses upper extremity functional ability including grasp, grip, pinch, and gross movement.

  Baseline and Week 3 (Post-intervention)

Secondary Outcomes (4)

• Motor Activity Log (MAL)

  Baseline and Week 3

• Box and Block Test (BBT)

  Baseline and Week 3

• Jebsen-Taylor Hand Function Test (JTHFT)

  Baseline and Week 3

• Adult Assisting Hand Assessment (Ad-AHA)

  Baseline and Week 3

Study Arms (2)

Constraint Induced Movement Therapy Group

EXPERIMENTAL

Participants in this arm will receive Constraint Induced Movement Therapy for 3 weeks. The unaffected arm will be constrained with a mitt for 90% of waking hours, and the affected arm will receive intensive task-oriented training for 2 hours per day, 5 days per week. Training tasks will include reaching, grasping, manipulating, dressing, and eating activities. Participants will also receive standard physiotherapy for mobility and postural control.

Behavioral: Constraint Induced Movement Therapy

Hand-Arm Bimanual Intensive Training Group

ACTIVE COMPARATOR

Participants in this arm will receive Hand-Arm Bimanual Intensive Training for 3 weeks. Training will be provided for 2 hours per day, 5 days per week, using symmetrical and asymmetrical bimanual activities such as folding clothes and pouring water. Participants will also receive standard physiotherapy for mobility and postural control.

Behavioral: Hand-Arm Bimanual Intensive Training

Interventions

Constraint Induced Movement Therapy BEHAVIORAL

Constraint Induced Movement Therapy will be provided for 3 weeks. The unaffected upper limb will be constrained with a mitt for 90% of waking hours. Participants will receive intensive task-oriented training of the affected upper limb for 2 hours per day, 5 days per week. Activities will include reaching, grasping, manipulating objects, dressing, and eating tasks. Standard physiotherapy for mobility and postural control will also be provided.

Also known as: CIMT

Constraint Induced Movement Therapy Group

Hand-Arm Bimanual Intensive Training BEHAVIORAL

Hand-Arm Bimanual Intensive Training will be provided for 3 weeks. Participants will receive supervised bimanual upper limb training for 2 hours per day, 5 days per week. Activities will include symmetrical and asymmetrical bilateral tasks such as folding clothes, pouring water, object transfer, and coordinated hand use. Standard physiotherapy for mobility and postural control will also be provided.

Hand-Arm Bimanual Intensive Training Group

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults aged 40 years and above.
• Diagnosed with unilateral ischemic or hemorrhagic stroke.
• Stroke duration between 3 to 6 months.
• Mini-Mental State Examination score of 24 or above.
• Able and willing to provide informed consent.

You may not qualify if:

• Severe pain in the more affected upper limb on verbal rating scale.
• Spasticity greater than 3 on the Modified Ashworth Scale in the affected upper limb.
• Unstable cardiovascular conditions.
• Any traumatic musculoskeletal injury of the upper limb.

Sponsors & Collaborators

• Riphah International University: lead

Study Sites (1)

Riphah College of Rehabilitation Sciences

Lahore, Punjab Province, 55100, Pakistan

Location

MeSH Terms

Conditions

Stroke

Interventions

Constraint Induced Movement Therapy

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Exercise Therapy; Physical Therapy Modalities; Therapeutics; Rehabilitation

Study Officials

• Ambreen I IQBAL

  Riphah International University Role

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: The outcome assessor will remain blinded to group allocation during baseline and post-intervention assessments.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: participants will be randomly allocated into two groups: Constraint Induced Movement Therapy group and Hand-Arm Bimanual Intensive Training group.

Study Record Dates

• First Submitted: June 1, 2026
• First Posted: June 4, 2026
• Study Start: June 5, 2025
• Primary Completion (Estimated): July 6, 2026
• Study Completion (Estimated): August 6, 2026
• Last Updated: June 4, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)