NCT07441057

Brief Summary

Pediatric stroke poses significant challenges due to its impact on a child's developing brain. Both ischemic and hemorrhagic strokes in children can result in long-term motor, sensory, and cognitive impairments, particularly affecting upper limb function. Comprehensive Hand Repetitive Intensive Strength Training is a structured intervention model that integrates high-repetition, strength-based, and goal-oriented exercises targeting upper limb coordination and use. This study aims to explore the efficacy of CHRIST in improving upper limb function using the ABILHAND-Kids questionnaire to assess changes in manual ability. The study aims to generate pediatric-specific evidence for intensive hand-focused rehabilitation strategies.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
15

participants targeted

Target at below P25 for not_applicable stroke

Timeline
3mo left

Started Feb 2026

Shorter than P25 for not_applicable stroke

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress52%
Feb 2026Aug 2026

Study Start

First participant enrolled

February 4, 2026

Completed
19 days until next milestone

First Submitted

Initial submission to the registry

February 23, 2026

Completed
4 days until next milestone

First Posted

Study publicly available on registry

February 27, 2026

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 30, 2026

Expected
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

August 30, 2026

Last Updated

February 27, 2026

Status Verified

February 1, 2026

Enrollment Period

6 months

First QC Date

February 23, 2026

Last Update Submit

February 23, 2026

Conditions

Stroke

Outcome Measures

Primary Outcomes (1)

  • ABILHAND-Kids

    The ABILHAND-Kids is specifically developed to evaluate upper limb function in children and adolescents with neurological impairments, making them highly sensitive to changes in motor performance

    Baseline and after 10 weeks

Study Arms (1)

CHRIST will be given to childrenwith pediatric stroke

EXPERIMENTAL
Other: CHRIST

Interventions

CHRISTOTHER

A session of 40 minutes, which includes 3 sets (10 minutes exercise with 3 minutes rest period per set), three times a week, over a 10 weeks period. The speed of the treadmill for the upper limbs will be 0.3-1.2 km/h.

CHRIST will be given to childrenwith pediatric stroke

Eligibility Criteria

Age7 Years - 12 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17)

You may qualify if:

  • Children aged 7 to 12 years diagnosed with pediatric ischemic or hemorrhagic stroke(21).
  • Clinical evidence of upper limb motor impairment following stroke.
  • Parent/guardian consent and child assent obtained.

You may not qualify if:

  • Severe cognitive or behavioral impairments interfering with therapy.
  • Uncontrolled seizures or medical conditions contraindicating exercise.
  • Previous participation in intensive upper limb therapy within the last 3 months.
  • Orthopedic conditions (e.g., fractures, contractures) that limit upper limb movement.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Clinical settings having pediatric stroke patients.

Mandi Bahāuddīn, Punjab Province, 5400, Pakistan

RECRUITING

Related Publications (3)

  • Amlie-Lefond C, Sebire G, Fullerton HJ. Recent developments in childhood arterial ischaemic stroke. Lancet Neurol. 2008 May;7(5):425-35. doi: 10.1016/S1474-4422(08)70086-3.

    PMID: 18420156BACKGROUND

  • Kim DA, Lee JA, Hwang PW, Lee MJ, Kim HK, Park JJ, You JH, Lee DR, Lee NG. The Effect of Comprehensive Hand Repetitive Intensive Strength Training (CHRIST) Using Motion Analysis in Children with Cerebral Palsy. Ann Rehabil Med. 2012 Feb;36(1):39-46. doi: 10.5535/arm.2012.36.1.39. Epub 2012 Feb 29.

    PMID: 22506234BACKGROUND

  • Kabir R, Sunny MSH, Ahmed HU, Rahman MH. Hand Rehabilitation Devices: A Comprehensive Systematic Review. Micromachines (Basel). 2022 Jun 29;13(7):1033. doi: 10.3390/mi13071033.

    PMID: 35888850BACKGROUND

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesVascular DiseasesCardiovascular Diseases

Study Officials

  • Mashar Hayat, MS

    Riphah International University, Lahore

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Imran Amjad, Phd

CONTACT

03324390125imran.amjad@riphah.edu.pk

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 23, 2026

First Posted

February 27, 2026

Study Start

February 4, 2026

Primary Completion (Estimated)

July 30, 2026

Study Completion (Estimated)

August 30, 2026

Last Updated

February 27, 2026

Record last verified: 2026-02

Data Sharing

IPD Sharing
Will not share

Locations

PA(1)