Gac Fruit Oil Supplementation for Visual Health and Sleep Quality

NCT07623070 | Completed

• 1 other identifier: YPU-IRB-1110708
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

This study evaluated the effects of gac fruit oil supplementation on visual health, sleep quality, depressive symptoms, cognitive function, and brain imaging parameters in adults with sleep disturbance. Participants aged 40 to 65 years were recruited and received gac fruit oil capsules for 30 days. The supplementation protocol consisted of two capsules in the morning and two capsules in the evening each day. Assessments were performed before and after the intervention, including macular pigment measurement, ocular surface disease evaluation, tear film analysis, contrast sensitivity testing, accommodative microfluctuation analysis, optical coherence tomography, the Pittsburgh Sleep Quality Index, a depression scale, the Mini-Mental State Examination, and brain magnetic resonance imaging. The study aimed to explore whether 30 days of gac fruit oil supplementation was associated with changes in visual function, sleep quality, mood-related measures, cognitive function, and brain imaging findings.

Conditions

Sleep Disturbance; Visual Health

Keywords

Gac fruit oil; Momordica cochinchinensis; Sleep quality; Visual health; Depressive symptoms

Outcome Measures

Primary Outcomes (1)

• Change in Sleep Quality

  Sleep quality was assessed using the Pittsburgh Sleep Quality Index before and after 30 days of gac fruit oil supplementation.

  Baseline and 30 days

Secondary Outcomes (9)

• Change in Depressive Symptoms

  Baseline and 30 days

• Change in Macular Pigment Level

  Baseline and 30 days

• Change in Ocular Surface Disease Symptoms

  Baseline and 30 days

• Change in Tear Film Parameters

  Baseline and 30 days

• Change in Contrast Sensitivity

  Baseline and 30 days

Study Arms (1)

Gac Fruit Oil Supplementation

EXPERIMENTAL

Participants received gac fruit oil capsules for 30 days. The supplementation protocol consisted of two capsules in the morning and two capsules in the evening each day.

Dietary Supplement: Gac Fruit Oil Capsules

Interventions

Gac Fruit Oil Capsules DIETARY_SUPPLEMENT

Participants took gac fruit oil capsules orally for 30 days. The supplementation protocol consisted of two capsules in the morning and two capsules in the evening each day, for a total of four capsules per day.

Also known as: Momordica cochinchinensis Oil Capsules

Gac Fruit Oil Supplementation

Eligibility Criteria

• Age: 40 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults aged 40 to 65 years.
• Participants with sleep disturbance.
• Participants who were willing to participate in the study and provide written informed consent.

You may not qualify if:

• History of ocular surgery.
• Cataract.
• Glaucoma.
• Current supplementation intended to increase macular pigment level.
• Pregnancy.
• Severe illness.
• Use of medications that may affect or stimulate sleep.
• Use of medications that promote sleep.
• Unable to undergo magnetic resonance imaging, including but not limited to individuals with a pacemaker, artificial heart valve, metal aneurysm clip, metallic tracheostomy tube, possible metallic fragments in the orbit, cochlear implant, implanted electrodes, neurostimulator, implanted drug infusion device, hemostatic clips, vascular stents, claustrophobia, previous brain surgery, or history of traumatic brain injury with implanted metal materials.
• Participants who experienced discomfort during the study or wished to withdraw could discontinue participation at any time without providing a reason.

Sponsors & Collaborators

• Yuanpei University of Medical Technology: lead

Study Sites (1)

Yuanpei University of Medical Technology

Hsinchu, 30015, Taiwan

Location

MeSH Terms

Conditions

Parasomnias; Sleep Initiation and Maintenance Disorders; Depression

Condition Hierarchy (Ancestors)

Sleep Wake Disorders; Nervous System Diseases; Mental Disorders; Sleep Disorders, Intrinsic; Dyssomnias; Behavioral Symptoms; Behavior

Study Officials

• Chao-Kai Chang

  Yuanpei University of Medical Technology

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: All participants received the same intervention: gac fruit oil capsules for 30 days. Outcomes were assessed before and after the intervention.

Study Record Dates

• First Submitted: May 28, 2026
• First Posted: June 3, 2026
• Study Start: September 1, 2022
• Primary Completion: July 16, 2023
• Study Completion: July 16, 2023
• Last Updated: June 3, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)