Effect of Osteopathic Manipulation on Circulating Immune Markers

NCT07622966 | Completed

• 2 other identifiers: 2153344-124081882
• Study Type: interventional
• Target: 33
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to learn if osteopathic manipulative treatment (OMT) changes levels of immune markers in healthy volunteers. The main questions it aims to answer are: Does OMT change numbers of white blood cells or antibodies? Does OMT change levels of cytokines? Researchers will compare volunteers treated with OMT to volunteers undergoing sham treatment to see if OMT changes levels of immune markers. Participants will:

• complete a survey about their medical history to determine if they are healthy enough for OMT
• have blood drawn
• undergo either sham treatment or OMT
• have blood drawn 30 minutes after treatment

Conditions

Osteopathic Manipulative Treatment (OMT); Healthy Adult Participants

Outcome Measures

Primary Outcomes (1)

• Changes in Circulating Immune Markers

  within 30 minutes of treatment

Study Arms (2)

Osteopathic Manipulative Treatment (OMT)

EXPERIMENTAL

Other: Osteopathic Manipulative Treatment (OMT)

Sham Treatment

SHAM COMPARATOR

Other: Sham Comparator

Interventions

Osteopathic Manipulative Treatment (OMT) OTHER

Lymphatic Pump Techniques

Osteopathic Manipulative Treatment (OMT)

Sham Comparator OTHER

Light touch

Sham Treatment

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• subjects are healthy; have independently read, understood, and without coercion signed the consent form; agree to allow for samples to be taken; agree to fill out all the documentation and surveys; and identifies as any race(s), ethnicity(ies), and/or gender(s)

You may not qualify if:

• subjects present at initial visit with a fever greater than 100.5 °F; have participated in a clinical trial within the last 6 months; work night shifts; who are immunocompromised including: HIV+, have had cancers, or are pregnant or nursing; have current bone fractures of the head and neck; history of osteoporosis, acute hepatitis, deep vein thrombosis, pulmonary embolism, trauma to the liver or spleen, surgery in the past 6 months or necrotizing fasciitis. Other relative contraindications to receiving OMT include doderate to severe cardiac conditions, moderate to severe congestive heart failure, infectious mononucleosis, chronic abscesses or osteomyelitis, coagulopathies or patients on anticoagulants, COPD, and acute indurated lymph node

Sponsors & Collaborators

• American Osteopathic Association: collaborator
• Edward Via Virginia College of Osteopathic Medicine: lead

Study Sites (1)

Edward Via College of Osteopathic Medicine

Monroe, Louisiana, 71203, United States

Location

MeSH Terms

Interventions

Manipulation, Osteopathic

Intervention Hierarchy (Ancestors)

Musculoskeletal Manipulations; Complementary Therapies; Therapeutics; Physical Therapy Modalities; Rehabilitation

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Discipline Chair for Immunology and Microbiology

Study Record Dates

• First Submitted: May 28, 2026
• First Posted: June 3, 2026
• Study Start: January 10, 2025
• Primary Completion: June 17, 2025
• Study Completion: June 17, 2025
• Last Updated: June 3, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)