Odontogenic Graft Obtained From Human Tooth and Low Level Laser Therapy

NCT07615361 | Enrolling By Invitation

• 1 other identifier: 85
• Study Type: interventional
• Target: 21
• Locations: 1 country
• Sites: 1

Brief Summary

This clinical trial aims to evaluate the effectiveness of an odontogenic graft obtained from extracted human teeth, with and without adjunctive low-level laser therapy (LLLT), on bone regeneration following posterior tooth extraction in systemically healthy adult patients. The study investigates whether the combination of autogenous tooth-derived graft material and LLLT enhances alveolar bone healing and preservation compared to grafting alone, prior to implant-supported posterior rehabilitation.

Conditions

Laser Therapy; Periodontal Diseases; Bone Loss in Jaw; Alveolar Bone Loss; Periodontal Bone Loss; Periodontal Atrophy

Outcome Measures

Primary Outcomes (1)

• Mean change in horizontal alveolar ridge width (mm) from baseline to 4 months (CBCT)

  Horizontal alveolar ridge width will be measured in millimeters using cone-beam computed tomography (CBCT) at baseline (immediately after tooth extraction) and at 4 months postoperatively prior to implant placement. The primary outcome will be defined as the mean change in ridge width (Δ width = width at 4 months - width at baseline), expressed in millimeters.

  Baseline (immediately after tooth extraction) and 4 months postoperatively (prior to implant placement)

Secondary Outcomes (1)

• Mean change in vertical alveolar ridge height (mm) from baseline to 4 months (CBCT)

  Baseline (immediately after tooth extraction) and 4 months postoperatively (prior to implant placement)]

Other Outcomes (1)

• Percentage of Newly Formed Bone Measured by Histomorphometric Analysis of Bone Biopsy Specimens

  Baseline (immediately after tooth extraction) and 4 months postoperatively (prior to implant placement)]

Study Arms (2)

Control Group

EXPERIMENTAL

Dentin graft socket preservation

Biological: Autogenous Tooth-Derived Bone Graft

Test Group

EXPERIMENTAL

Dentin graft socket preservation+LLLT

Device: Low-Level Laser Therapy (LLLT)

Interventions

Autogenous Tooth-Derived Bone Graft BIOLOGICAL

Autogenous Tooth-Derived Bone Graft prepared using the BonMaker® ATB device from extracted human teeth. Following atraumatic tooth extraction, teeth will be mechanically ground and chemically processed according to the manufacturer's standardized protocol to obtain particulate autogenous graft material containing dentin and enamel components. The graft material will be placed immediately into extraction sockets for alveolar ridge preservation prior to implant placement.

Control Group

Low-Level Laser Therapy (LLLT) DEVICE

Adjunctive low-level laser therapy (LLLT) performed using a 650 nm diode laser device (Woodpecker DTE D-Laser Blue) with a 6 mm fiber applicator in continuous contact mode at an output power of 25 mW and an energy density of 0.500 J/cm². Laser irradiation will be applied to grafted extraction sockets immediately after extraction, after flap closure, and during postoperative follow-up visits according to a standardized treatment protocol to enhance soft tissue healing and bone regeneration.

Test Group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients requiring tooth extraction due to periodontal reasons (teeth with a hopeless prognosis), root caries, or root fractures, who are simultaneously candidates for posterior replacement with an osseointegrated implant, and who require extraction of at least two teeth.
• Integrity of the alveolar socket walls following tooth extraction.
• Patients who accept the study conditions, sign written informed consent, and agree to attend the scheduled follow-up visits.

You may not qualify if:

• General contraindications for dental and/or surgical treatments.
• Inflammatory or autoimmune diseases of the oral cavity.
• Uncontrolled diabetes mellitus (HbA1c \> 7%).
• History of malignancy requiring chemotherapy or radiotherapy within the past 5 years.
• Previous treatment with immunosuppressive agents, bisphosphonates, or high-dose corticosteroids.
• Smoking more than 10 cigarettes per day.
• Pregnant or breastfeeding women.

Sponsors & Collaborators

• Istanbul Saglik Bilimleri University: lead

Study Sites (1)

Health Sciences University

Istanbul, Uskudar, 34668, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Periodontal Diseases; Alveolar Bone Loss; Periodontal Atrophy

Interventions

Low-Level Light Therapy

Condition Hierarchy (Ancestors)

Mouth Diseases; Stomatognathic Diseases; Bone Resorption; Bone Diseases; Musculoskeletal Diseases

Intervention Hierarchy (Ancestors)

Laser Therapy; Therapeutics; Phototherapy

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: associate professor

Study Record Dates

• First Submitted: February 23, 2026
• First Posted: May 29, 2026
• Study Start: February 2, 2026
• Primary Completion (Estimated): August 1, 2026
• Study Completion (Estimated): September 1, 2026
• Last Updated: May 29, 2026

Record last verified: 2026-05

Locations

TU (1)