Injectable Platelet-Rich Fibrin With Minimally Invasive Non-Surgical Technique in Treatment of Periodontal Intrabony Defects

NCT07613606 | Recruiting

• 1 other identifier: 23110280p
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to clinically and radiographically evaluate the adjunctive effect of injectable platelet-rich fibrin (i-PRF) used in combination with a minimally invasive non-surgical technique for the regenerative treatment of intrabony periodontal defects.

Conditions

Platelet-Rich Fibrin; Minimally Invasive Non-Surgical Technique; Periodontal Intrabony Defects

Outcome Measures

Primary Outcomes (1)

• Presence of comparable bilateral-walled intrabony defects

  Assessment of intrabony defect fill radiographically will be measured using the standardized paralleling technique. Presence of comparable bilateral-walled intrabony defects (PPD, \> 5 mm with intrabony defect depth ≥ 3 mm, from the alveolar crest to the defect base, at screening radiograph) not in a furcation-involved tooth.

  6 months postoperatively

Secondary Outcomes (5)

• Clinical attachment level

  6 months postoperatively

• Interproximal probing depth

  6 months postoperatively

• Gingival margin

  6 months postoperatively

• Bleeding on probing

  6 months postoperatively

• Plaque index

  6 months postoperatively

Study Arms (2)

Group 1 (control group)

ACTIVE COMPARATOR

Patients will receive minimally invasive non-Surgical technique (MINST) alone

Procedure: Minimally invasive non-Surgical technique

Group 2 (Test group)

EXPERIMENTAL

Patients will receive minimally invasive non-Surgical technique (MINST)+ injectable platelet-rich fibrin (i-PRF) injection

Procedure: Minimally invasive non-Surgical technique + platelet-rich fibrin

Interventions

Minimally invasive non-Surgical technique PROCEDURE

Patients will receive minimally invasive non-Surgical technique (MINST) alone

Group 1 (control group)

Minimally invasive non-Surgical technique + platelet-rich fibrin PROCEDURE

Patients will receive minimally invasive non-Surgical technique (MINST)+ injectable platelet-rich fibrin (i-PRF) injection

Group 2 (Test group)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients of both genders \>18 years old, medically free of systemic diseases affecting periodontal regeneration.
• Diagnosis of 'periodontitis' stage III (grades B or C).
• Single-rooted and multi-rooted vital teeth in either the maxilla or the mandible.
• Presence of comparable bilateral two- or three-walled intrabony defects \[probing pocket depth (PPD), \> 5 mm with intrabony defect depth ≥ 3 mm, from the alveolar crest to the defect base, at screening radiograph\] not in a furcation-involved tooth.

You may not qualify if:

• Patients with systemic illness known to affect the outcome of periodontal therapy, including diabetes, immune deficiencies, etc.
• Pregnant and lactating women
• Current use of any form of tobacco.
• Non-surgical periodontal treatment in the past 6 months, or surgical periodontal treatment in the past 12 months.
• Degree 2 or 3 mobility of the involved sites.6.
• Presence of periapical pathology, acute infection, or subgingival restoration which could interfere with clinical measurements.

Sponsors & Collaborators

• October 6 University: lead

Study Sites (1)

October 6 University

Cairo, 12511, Egypt

RECRUITING

Central Study Contacts

Amir R Elngar, B.D.S

CONTACT

00201004634587; amirreda059@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: B.D.S Faculty of Dentistry, October 6 University, Egypt.

Study Record Dates

• First Submitted: May 13, 2026
• First Posted: May 29, 2026
• Study Start: March 1, 2026
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: May 29, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: After the end of study for one year.
• Access Criteria: The data will be available upon a reasonable request from the corresponding author.

Locations

EG (1)