Impact of Platelet-Rich Fibrin on Periodontal Tissue Regeneration

NCT07395726 | Completed DMC

• 1 other identifier: 21MDC1
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this research is to assess the efficacy of Platelet-Rich Fibrin (PRF) in the regeneration of periodontal tissues in patients suffering from periodontal disease. Periodontal disease is a chronic inflammatory disease that affects the gums and the bone supporting the teeth, which can eventually result in the loss of teeth if left untreated. Conventional periodontal treatment can control the infection and halt the progression of the disease but cannot reverse the loss of the supporting structures. Platelet-Rich Fibrin is a biologic material derived from a small amount of the patient's own blood. It has growth factors that can potentially enhance healing and facilitate the regeneration of bone and soft tissues. In this randomized controlled clinical trial, patients will be randomly assigned to either conventional periodontal surgical treatment or conventional treatment along with PRF. Over a predetermined follow-up period, clinical measurements like gum pocket depth, attachment levels, and radiographic bone changes will be assessed to see if PRF offers any extra advantages in tissue healing and regeneration. The results of this study could improve long-term oral health outcomes and periodontal disease treatment approaches.

Conditions

Periodontitis; Periodontal Intrabony Defects

Keywords

Platelet-Rich Fibrin; Periodontitis; Periodontal Regeneration; Probing Pocket Depth; Clinical Attachment Level

Outcome Measures

Primary Outcomes (1)

• Change in Probing Pocket Depth (PPD)

  Probing pocket depth will be measured in millimeters using a calibrated periodontal probe at the selected defect sites. The outcome will be defined as the mean reduction in PPD from baseline to 6 months following surgery.

  Baseline to 6 months postoperatively.

Secondary Outcomes (2)

• Change in Clinical Attachment Level (CAL)

  Baseline to 6 months postoperatively.

• Percentage of Radiographic Bone Fill

  Baseline to 6 months postoperatively.

Study Arms (2)

Open Flap Debridement

PLACEBO COMPARATOR

Participants assigned to this arm will undergo conventional open flap debridement (OFD) for the treatment of periodontal intrabony defects. The procedure involves flap elevation, thorough debridement of granulation tissue, root surface instrumentation, defect decontamination, and flap repositioning with suturing. Standard postoperative care and oral hygiene instructions will be provided.

Procedure: Open Flap Debridement

Platelet-Rich Fibrin with Open Flap Debridement

EXPERIMENTAL

Participants assigned to this arm will receive autologous Platelet-Rich Fibrin (PRF) as an adjunct to conventional open flap debridement. PRF will be prepared from the participant's venous blood using centrifugation and placed directly into the periodontal defect prior to flap closure to promote tissue regeneration and enhance healing. All other surgical and postoperative procedures will be identical to the control group.

Procedure: Platelet-Rich Fibrin with Open Flap Debridement

Interventions

Open Flap Debridement PROCEDURE

Participants assigned to this arm will undergo conventional open flap debridement (OFD) for the treatment of periodontal intrabony defects. The procedure involves flap elevation, thorough debridement of granulation tissue, root surface instrumentation, defect decontamination, and flap repositioning with suturing. Standard postoperative care and oral hygiene instructions will be provided.

Open Flap Debridement

Platelet-Rich Fibrin with Open Flap Debridement PROCEDURE

Participants assigned to this arm will receive autologous Platelet-Rich Fibrin (PRF) as an adjunct to conventional open flap debridement. PRF will be prepared from the participant's venous blood using centrifugation and placed directly into the periodontal defect prior to flap closure to promote tissue regeneration and enhance healing. All other surgical and postoperative procedures will be identical to the control group.

Platelet-Rich Fibrin with Open Flap Debridement

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Adults aged 18-65 years. Diagnosed with chronic periodontitis according to standard clinical criteria. Presence of periodontal intrabony defects suitable for surgical intervention. Probing pocket depth (PPD) ≥ 5 mm at the target site. Clinical attachment level (CAL) loss ≥ 3 mm at the target site. Good oral hygiene, with full-mouth plaque score \< 25%.

You may not qualify if:

• Patients with systemic diseases that affect healing (e.g., uncontrolled diabetes, immunodeficiency).
• Pregnant or lactating women. Current smokers or tobacco users. History of periodontal surgery at the target site within the last 12 months. Use of medications that interfere with wound healing (e.g., corticosteroids, bisphosphonates).
• Allergies or contraindications to local anesthetics or components used in the study.
• Active oral infections or untreated caries at or near the target site.

Sponsors & Collaborators

• Armed Forces Institute of Dentistry, Pakistan: lead

Study Sites (1)

Armed Forces Institute of Dentistry

Rawalpindi, 46000, Pakistan

Location

MeSH Terms

Conditions

Periodontitis

Condition Hierarchy (Ancestors)

Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr

Study Record Dates

• First Submitted: February 1, 2026
• First Posted: February 9, 2026
• Study Start: May 20, 2025
• Primary Completion: October 25, 2025
• Study Completion: November 15, 2025
• Last Updated: February 9, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)