Comparison of Effects of Eggshell Derived Nano Hydroxyapatite and Hydroxyapatite in Management of Periodontal Intrabony Defects
"Comparative Efficacy Of Eggshell Derived Nano Hydroxyapatite Over Hydroxyapatite In The Treatment Of Periodontal Intrabony Defects: A Clinico-Radiographic Study"
1 other identifier
interventional
28
1 country
1
Brief Summary
The aim of the study is to evaluate osseous regenerative efficacy of eggshell derived nanohydroxyapatite in comparison with hydroxyapatite The test group includes patients with intrabony defects where flap surgery will be performed \& Eggshell derived nano hydroxyapatite (ESnHA) is placed.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Mar 2023
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 22, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 13, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
March 27, 2025
CompletedFirst Submitted
Initial submission to the registry
August 30, 2025
CompletedFirst Posted
Study publicly available on registry
September 8, 2025
CompletedSeptember 15, 2025
August 1, 2025
1.4 years
August 30, 2025
September 8, 2025
Conditions
Outcome Measures
Primary Outcomes (3)
RVG
Radiovisiography will be used to assess bone regeneration achieved post operatively
3months & 6months
Probing Depth
3 months & 6months
Clinical Attachment Level
3 months & 6 months
Secondary Outcomes (2)
Full mouth Plaque index
3 months & 6 months
Full mouth Gingival index
3 months & 6 months
Study Arms (2)
Test group Eggshell derived nano hydroxyapatite
EXPERIMENTALIn Test group after flap reflection \& degranulation, bone graft i.e Eggshell derived nano hydroxyapatite is placed into defect.
Control group
ACTIVE COMPARATORIn Control group, after flap reflection \& debridment bone graft i.e Hydroxyapatite is placed into defect.
Interventions
Eggshell derived nano hydroxyapatite has high solubility and allows faster integration \& replaces with osseous tissue
Hydroxyapatite has similar chemical composition with crystalline structure of native bone
Eligibility Criteria
You may qualify if:
- Presence of Two-walled or three-walled intrabony defects \& Probing pocket depths (PPD) of \>5mm after initial therapy Systemically healthy male and female patients of age \>18 years
You may not qualify if:
- Medically compromised patients Pregnant women, Heavy smokers, and Patients who underwent radiotherapy or chemotherapy
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Svs Institute of Dental Sciences
Mahbūbnagar, Telangana, 509001, India
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- PROFFESSOR AND HEAD OF THE DEPARTMENT
Study Record Dates
First Submitted
August 30, 2025
First Posted
September 8, 2025
Study Start
March 22, 2023
Primary Completion
August 13, 2024
Study Completion
March 27, 2025
Last Updated
September 15, 2025
Record last verified: 2025-08