RIPB Versus EOIPB for Pain Control After Laparoscopic Cholecystectomy

NCT07607262 | Completed

• 1 other identifier: RIPB-EOIPB-LC-01
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective observational study aims to compare the effects of bilateral ultrasound-guided recto-intercostal plane block(RIPB) and bilateral ultrasound-guided external oblique intercostal plane block(EOIPB) on postoperative analgesia in patients undergoing elective laparoscopic cholecystectomy under general anesthesia. Both blocks are performed after anesthesia induction as part of routine preemptive multimodal analgesia practice. Patients who receive bilateral recto-intercostal plane block will be included in the RIPB group, and patients who receive bilateral external oblique intercostal plane block will be included in the EOIPB group. The primary outcome is cumulative intravenous tramadol consumption via patient-controlled analgesia during the first 24 postoperative hours. Secondary outcomes include postoperative pain scores at rest and during activity, rescue analgesic requirement, postoperative nausea and vomiting, time to mobilization, length of hospital stay, quality of recovery assessed using the Quality of Recovery-15 questionnaire, and block-related complications.

Conditions

Laparoscopic Cholecystectomy; Postoperative Pain; Postoperative Analgesia

Keywords

Recto-intercostal plane block; External oblique intercostal plane block; Ultrasound-guided fascial plane block; Patient-controlled analgesia; Quality of recovery; Numeric Rating Scale

Outcome Measures

Primary Outcomes (1)

• Cumulative Postoperative Tramadol Consumption

  Total intravenous tramadol consumption delivered via patient-controlled analgesia during the first 24 hours after surgery.

  Postoperative 24 hours

Secondary Outcomes (8)

• Postoperative Pain Scores at Rest

  Postoperative 20 minutes, 40 minutes, 1, 3, 6, 12, 18, and 24 hours

• Postoperative Pain Scores During Activity

  Postoperative 20 minutes, 40 minutes, 1, 3, 6, 12, 18, and 24 hours

• Quality of Recovery

  Postoperative 24 hours

• Rescue Analgesic Requirement

  Postoperative 24 hours

• Postoperative Nausea and Vomiting

  Postoperative 24 hours

Study Arms (2)

RIPB Group

Patients who received bilateral ultrasound-guided recto-intercostal plane block after anesthesia induction as part of routine preemptive analgesia for elective laparoscopic cholecystectomy.

Procedure: Bilateral Ultrasound-Guided Recto-Intercostal Plane Block

EOIPB Group

Patients who received bilateral ultrasound-guided external oblique intercostal plane block after anesthesia induction as part of routine preemptive analgesia for elective laparoscopic cholecystectomy.

Procedure: Bilateral Ultrasound-Guided External Oblique Intercostal Plane Block

Interventions

Bilateral Ultrasound-Guided External Oblique Intercostal Plane Block PROCEDURE

Bilateral external oblique intercostal plane block was performed under ultrasound guidance after anesthesia induction. Local anesthetic was injected into the fascial plane between the external oblique muscle and the intercostal muscles as part of routine preemptive analgesia.

EOIPB Group

Bilateral Ultrasound-Guided Recto-Intercostal Plane Block PROCEDURE

Bilateral recto-intercostal plane block was performed under ultrasound guidance after anesthesia induction. Local anesthetic was injected into the fascial plane between the rectus abdominis muscle and the intercostal structures as part of routine preemptive analgesia.

RIPB Group

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adult patients aged 18-75 years with American Society of Anesthesiologists (ASA) physical status I-III who are scheduled for elective laparoscopic cholecystectomy under general anesthesia and who provide written informed consent will be included.

You may qualify if:

• Age between 18 and 75 years
• American Society of Anesthesiologists (ASA) physical status I-III
• Scheduled for elective laparoscopic cholecystectomy under general anesthesia
• Written informed consent obtained

You may not qualify if:

• Refusal to participate
• Inability to understand the study protocol or provide informed consent
• Known allergy to local anesthetics, tramadol, paracetamol, dexketoprofen, or other study drugs
• Chronic opioid or steroid use
• Psychiatric or cognitive disorder preventing reliable pain assessment
• Inability to use patient-controlled analgesia
• Pregnancy or breastfeeding
• Coagulopathy
• Infection at the block site
• Difficult or prolonged intubation requiring three or more attempts
• Conversion to open surgery
• Surgery lasting longer than 120 minutes
• Intraoperative or postoperative complications requiring deviation from the standard analgesia protocol

Sponsors & Collaborators

• Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital: lead

Study Sites (1)

Sancaktepe Şehit Prof. Dr. İlhan Varank Training and Research Hospital

Sancaktepe, Istanbul, 34000, Turkey (Türkiye)

Location

Related Publications (4)

• Tulgar S, Ahiskalioglu A, Kilicaslan A, Ciftci B, Dost B, Aydin ME, Gurkan Y. Fascial plane blocks as the main anesthetic method: A narrative review. Saudi J Anaesth. 2025 Apr-Jun;19(2):198-208. doi: 10.4103/sja.sja_844_24. Epub 2025 Mar 25.

  PMID: 40255355 BACKGROUND

• Stark PA, Myles PS, Burke JA. Development and psychometric evaluation of a postoperative quality of recovery score: the QoR-15. Anesthesiology. 2013 Jun;118(6):1332-40. doi: 10.1097/ALN.0b013e318289b84b.

  PMID: 23411725 BACKGROUND

• Elsharkawy H, Kolli S, Soliman LM, Seif J, Drake RL, Mariano ER, El-Boghdadly K. The External Oblique Intercostal Block: Anatomic Evaluation and Case Series. Pain Med. 2021 Nov 26;22(11):2436-2442. doi: 10.1093/pm/pnab296.

  PMID: 34626112 BACKGROUND

• Tulgar S, Ciftci B, Ahiskalioglu A, Bilal B, Alver S, Sakul BU, Ansen G, Pence KB, Alici HA. Recto-intercostal fascial plane block: Another novel fascial plane block. J Clin Anesth. 2023 Oct;89:111163. doi: 10.1016/j.jclinane.2023.111163. Epub 2023 Jun 7. No abstract available.

  PMID: 37295124 BACKGROUND

MeSH Terms

Conditions

Pain, Postoperative

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 15, 2026
• First Posted: May 26, 2026
• Study Start: April 25, 2026
• Primary Completion: June 9, 2026
• Study Completion: June 9, 2026
• Last Updated: June 11, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)