NCT07604454

Brief Summary

This randomized controlled trial aims to evaluate the effectiveness of Muscle Energy Technique (MET) combined with Mulligan Mobilization With Movement (MWM) in patients with lateral epicondylitis (tennis elbow). The study compares the combined intervention with Mulligan technique and routine physical therapy alone. Outcomes including pain intensity, functional disability, and quality of life will be assessed using NPRS, PRTEE, and SF-8 questionnaires over a four-week treatment period.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
40

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Sep 2025

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 26, 2025

Completed
1 month until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 28, 2025

Completed
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

January 25, 2026

Completed
4 months until next milestone

First Submitted

Initial submission to the registry

May 17, 2026

Completed
5 days until next milestone

First Posted

Study publicly available on registry

May 22, 2026

Completed
Last Updated

May 22, 2026

Status Verified

May 1, 2026

Enrollment Period

1 month

First QC Date

May 17, 2026

Last Update Submit

May 17, 2026

Conditions

Keywords

Tennis ElbowLateral EpicondylitisMuscle Energy TechniqueMulligan TechniqueMobilization With Movement

Outcome Measures

Primary Outcomes (1)

  • Pain Intensity Measured by Numeric Pain Rating Scale (NPRS)

    Pain intensity will be measured using the Numeric Pain Rating Scale (NPRS), an 11-point scale ranging from 0 (no pain) to 10 (worst imaginable pain).

    Baseline and after 4 weeks of intervention

Secondary Outcomes (2)

  • Functional Disability Measured by PRTEE Questionnaire

    Baseline and after 4 weeks of intervention

  • Quality of Life Measured by SF-8 Questionnaire

    Baseline and after 4 weeks of intervention

Study Arms (2)

Experimental Group (MET + MWM + Routine Physical Therapy)

EXPERIMENTAL

Participants in this group will receive Muscle Energy Technique combined with Mulligan Mobilization With Movement along with routine physical therapy including eccentric strengthening and stretching exercises for wrist extensors.

Procedure: Muscle Energy Technique Combined With Mulligan Technique

Control Group (MWM + Routine Physical Therapy)

ACTIVE COMPARATOR

Participants in this group will receive Mulligan Mobilization With Movement along with routine physical therapy including eccentric strengthening and stretching exercises.

Procedure: Mulligan Mobilization With Movement

Interventions

Muscle Energy Technique will be applied using resisted isometric contractions of forearm supination and pronation. Mulligan Mobilization With Movement will be applied using sustained lateral glide during pain-free gripping activity. Treatment sessions will be conducted five times weekly for four weeks.

Experimental Group (MET + MWM + Routine Physical Therapy)

Mulligan Mobilization With Movement technique will be applied using sustained glide of the forearm while participants perform pain-free gripping activities. Sessions will be conducted five times weekly for four weeks.

Control Group (MWM + Routine Physical Therapy)

Eligibility Criteria

Age18 Years - 45 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Age between 18 and 45 years
  • Both genders
  • Unilateral lateral epicondylitis
  • Diagnosed by senior physiotherapist
  • Pain duration of at least 6 weeks
  • Pain score ≥7 on NPRS/VAS
  • Positive symptoms during extensor carpi radialis brevis and longus isometric contraction

You may not qualify if:

  • Previous elbow or shoulder surgery
  • Manual therapy within previous 6 months
  • History of fracture, dislocation, or tendon tear
  • Steroid or pain medication use
  • Peripheral nerve entrapment
  • Cervical radiculopathy
  • Osteoporosis or metastasis involving elbow

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Lahore Teaching Hospital, Lahore

Lahore, Punjab Province, Pakistan

Location

Related Publications (10)

  • Bowman EN. Current concepts: pathology in the overhead athlete's lateral elbow. J Shoulder Elbow Surg. 2024 Feb;33(2):507-511. doi: 10.1016/j.jse.2023.08.017. Epub 2023 Sep 27.

    PMID: 37774828BACKGROUND
  • Blanchette MA, Normand MC. Augmented soft tissue mobilization vs natural history in the treatment of lateral epicondylitis: a pilot study. J Manipulative Physiol Ther. 2011 Feb;34(2):123-30. doi: 10.1016/j.jmpt.2010.12.001.

    PMID: 21334545BACKGROUND
  • Bazancir Z, Firat T. A potential factor in the pathophysiology of lateral epicondylitis: The long sarcomere length of the extensor carpi radialis brevis muscle and implications for physiotherapy. Med Hypotheses. 2019 Sep;130:109278. doi: 10.1016/j.mehy.2019.109278. Epub 2019 Jun 12.

    PMID: 31383324BACKGROUND
  • Bagcaci S, Unuvar BS, Gercek H, Ugurlu I, Sert OA, Yilmaz K. A randomized controlled trial on pain, grip strength, and functionality in lateral elbow pain: Mulligan vs muscle energy techniques. J Back Musculoskelet Rehabil. 2023;36(2):419-427. doi: 10.3233/BMR-220061.

    PMID: 36120766BACKGROUND
  • Alagaesan, J., & Nirmala, J. G. (2024). Effectiveness of Mulligan Mobilization Technique Versus Cyriax Technique for Lateral Epicondylitis: A Pilot Study. Indian Journal of Physiotherapy & Occupational Therapy, 18.

    BACKGROUND
  • Akbar H, Akbar S, Saddique MN, Sarfraz MS. Prevalence of lateral epicondylitis among housewives in Lahore: a cross-sectional study. BMC Musculoskelet Disord. 2024 Oct 15;25(1):815. doi: 10.1186/s12891-024-07889-x.

    PMID: 39407258BACKGROUND
  • Ahmed A, Ibrar M, Arsh A, Wali S, Hayat S, Abass S. Comparing the effectiveness of Mulligan mobilization versus Cyriax approach in the management of patients with subacute lateral epicondylitis. J Pak Med Assoc. 2021 Jan;71(1(A)):12-15. doi: 10.47391/JPMA.186.

    PMID: 33484510BACKGROUND
  • Afzal, M., Zakaullah, S., Memon, S. I., Nisar, A., Touqeer, H., & Shabir, H. (2021). Prevalence and risk factors of lateral epicondylitis among restaurant cooks at district Gujranwala: A cross-sectional study. Rawal Medical Journal, 46(2), 338.

    BACKGROUND
  • Aben A, De Wilde L, Hollevoet N, Henriquez C, Vandeweerdt M, Ponnet K, Van Tongel A. Tennis elbow: associated psychological factors. J Shoulder Elbow Surg. 2018 Mar;27(3):387-392. doi: 10.1016/j.jse.2017.11.033.

    PMID: 29433642BACKGROUND
  • Abd Elrahim, R. M., Ali, M. F., Elwerdany, S. H., Salama, A. M., & Elsayed, M. (2022). Mulligan mobilisation with movement versus deep friction massage in patients with lateral epicondylitis. J Pharm Negat Results, 13, 5184-5192.

    BACKGROUND

MeSH Terms

Conditions

Tennis Elbow

Interventions

Movement

Condition Hierarchy (Ancestors)

Elbow TendinopathyTendinopathyMuscular DiseasesMusculoskeletal DiseasesElbow InjuriesArm InjuriesWounds and InjuriesTendon Injuries

Intervention Hierarchy (Ancestors)

Physiological PhenomenaMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Masking Details
The study is single-blinded. The outcome assessor was blinded to the group allocation and intervention details to minimize assessment bias. Participants and treating physiotherapists were aware of the interventions being administered.
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: Participants will be randomly assigned into two parallel groups. One group will receive Muscle Energy Technique combined with Mulligan Mobilization With Movement and routine physical therapy, while the control group will receive Mulligan Mobilization With Movement with routine physical therapy alone.
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Doctor of Physical Therapy Student

Study Record Dates

First Submitted

May 17, 2026

First Posted

May 22, 2026

Study Start

September 26, 2025

Primary Completion

October 28, 2025

Study Completion

January 25, 2026

Last Updated

May 22, 2026

Record last verified: 2026-05

Data Sharing

IPD Sharing
Will not share

Individual participant data will not be shared because this study was conducted as an academic research project. The informed consent obtained from participants did not include provisions for public data sharing, and the dataset contains sensitive personal health information. Data will be stored securely and used only for academic and research purposes in accordance with institutional ethics approval.

Locations